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Antes Revista del Instituto Nacional de Enfermedades Respiratorias

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2010, Número 2

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Neumol Cir Torax 2010; 69 (2)


Receptor renina/prorenina y su relación con la fibrosis pulmonar idiopática

Montes ME

Idioma: Español
Referencias bibliográficas: 53
Paginas: 116-122
Archivo PDF: 803.69 Kb.


RESUMEN

El surgimiento de un nuevo componente del sistema renina-angiotensina, el receptor de renina/prorenina, provoca un giro inesperado en la interpretación de la fisiología de este sistema, cuyo papel clásico descrito es la regulación de la presión arterial. Este nuevo receptor aporta funciones a una proteína que hasta hace una década se pensaba sólo podía hidrolizar un sustrato (angiotensinógeno). Las evidencias de los últimos años señalan que el receptor renina/prorenina podría poseer un papel importante en la remodelación de la matriz extracelular en algunas patologías fibrosantes como el riñón y el corazón. En esta revisión se presentan los hallazgos más recientes del receptor renina/ prorenina y su participación en procesos fibrosantes que también podrían estar participando de manera importante en la patogénesis de la fibrosis pulmonar idiopática.


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