2009, Número 3
<< Anterior Siguiente >>
Patol Rev Latinoam 2009; 47 (3)
Tumores neuroendocrinos del aparato gastrointestinal y el páncreas
Alvarado CI
Idioma: Español
Referencias bibliográficas: 20
Paginas: 213-219
Archivo PDF: 331.06 Kb.
RESUMEN
Esta revisión proporciona los conceptos más actuales relacionados con la patogénesis y diagnóstico histopatológico de los tumores neuroendocrinos del aparato gastrointestinal y del páncreas. Los tumores del sistema difuso de células neuroendocrinas comprenden un grupo de neoplasias con morfología similar, pero difieren en sus características biológicas, pronósticas y aspectos moleculares. En el compartimiento gastroenteropancreático, se clasifican como tumores neuroendocrinos bien diferenciados, carcinomas de bajo grado o carcinomas poco diferenciados. Los tumores endocrinos pancreáticos son relativamente raros, representan 1 a 2% de todas las neoplasias de este órgano y la mayor parte son bien diferenciados.
REFERENCIAS (EN ESTE ARTÍCULO)
Modlin IM, Lye KD, Kidd M. A 5-decade analysis of 13,715 carcinoid tumors. Cancer 2003;97:934-59.
Maggard MA, O´Connell JB, Ko CY. Updated population based review of carcinoid tumors. Ann Surg 2004;240:117-22.
Creutzfeldt W. Historical background and natural history of carcinoids. Digestion 1994:55(Suppl. 3):3-10.
Kloppel G. Pathology and nomenclature of human gastrointestinal neuroendocrine (carcinoid) tumors and related lesions. World J Surg 1996;20:132-41.
Barbareschi M, Roldo C, Zamboni G, et al. CDX-2 homeobox gene product expression in neuroendocrine tumors: its role as a marker of intestinal neuroendocrine tumors: Its role as a marker of intestinal neuroendocrine tumors. Am J Surg Pathol 2004;28:1169-76.
van Eeden S, Offerhaus GJA. Historical, current and future perspectives on gastrointestinal and pancreatic endocrine tumors. Virchows Arch 2006;448:1-6.
Anlauf M, Perren A, Meyer CL, Schmid S, et al. Precursorlesions in patients with multiple endocrine neoplasia type 1-associated duodenal gastrinomas. Gastroenterology 2005;128:1187-98.
Prinz C, Zanner R, Gratzl M. Physiology of gastric enterochromaffin- like cells. Annu Rev Physiol 2003;65:371-82.
Hage E, Hendel L, Gustafsen J, Hendel J. Histopathology of the gastric oxyntic mucosa in two different patients groups during long-term treatment with omeprazole. Eur J Gastroenterol Hepatol 2003;15:781-9.
Muller J, Kirchner T, Muller-Hemerlink HK. Gastric endocrine cell hyperplasia and carcinoid tumors in atrophic gastritis type A. Am J Surg Pathol 1987;11:909-17.
Abraham SC, Carney JA, Ooi A, Choti MA, Argani P. Aclorhydria, parietal cell hyperplasia, and multiple gastric carcinoids: a new disorder. Am J Surg Pathol 2005;29:969-75.
Kloppel G. Tumor biology and histopathology of neuroendocrine tumours. Best Pract Res Clin Endocrinol Metab 2007;21:15-31.
Kloppel G, Clemens A. The biological relevance of gastric neuroendocrine tumors. Yale J Biol Med 1996;69:69-74.
Solcia E, Kloppel G, Sobin LH, Capella C, et al. Histopathological typing of endocrine tumors. World Health Organisation international histological classification of tumors. Berlin. 1st ed. Heidelberg: Springer-Verlag, 2000;pp:61-68.
William GT. Endocrine tumours of the gastrointestinal tractselected topic. Histopathology 2007;50:30-41.
Stephenson TJ. Prognostic and predictive factors in endocrine tumours. Histopathology 2000;48:629-43.
Capella C. Heitz PU, Hofler H. Solcia E, Kloppel G. Revised classification of neuroendocrine tumours of the lung; pancreas and gut. Virchows Arch 1995;425:547-60.
Jakobsen AM, Ahlman H, Wangberg B, Kolby L, et al. Expression of synaptic vesicle protein 2 (SV2) in neuroendocrine tumours of the gastrointestinal tract and pancreas. J Pathol 2002;196:44-50.
Heitz PU. Pancreatic endocrine tumors. In: Kloppel G, Heitz, editors. Pancreatic pathology. 1st ed. Edinburgh: Churchill Livingstone, 1984;p:206.
Rindi G; Capella C, Solcia E. Cell biology, clinicopathological profile, and classification of gastroenteropancreatic endocrine tumors. J Mol Med 1998;76:413-20.