Espinosa-de los Monteros LE, Aguilar-Ituarte F, Jiménez-Juárez RN, Rodríguez-Suárez RS, Gómez-Barreto D

Idioma: Español
Referencias bibliográficas: 36
Paginas: 4-13
Archivo PDF: 148.61 Kb.

RESUMEN

Objetivo. Evaluar el efecto de la inmunización con vacunav neumocóccica conjugada 7 valente (VCN7), sobre la colonización nasofaríngea por S. pneumoniae (SPN). Material y métodos. Se estudiaron dos grupos con diferente esquema de vacunación: grupo I (2-6 meses de edad) 3+1, grupo II (7-11 meses) 2+1, con refuerzo a los 15 meses de edad. Se realizaron cultivos nasofaríngeos antes de cada inmunización y posterior al refuerzo; se analizó de forma global y pareada las proporciones de los niños colonizados por SPN, serotipos vacunales, no vacunales y resistencia a la penicilina. Resultados. Se incluyeron 183 niños; 93 en el grupo I y 90 en el grupo II. En el grupo I disminuyeron los serotipos vacunales en la 3ª muestra. En el grupo II aumentaron los serotipos no vacunales y disminuyeron los serotipos vacunales antes del refuerzo. En ambos grupos hay una tendencia a disminuir la resistencia a penicilina. Conclusión. La VCN7 ocasiona un reemplazo de serotipos en la colonización nasofaríngea antes del refuerzo.

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