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Colegio de Medicina Interna de México.

2010, Número 3

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Med Int Mex 2010; 26 (3)


Medicamentos biológicos en artritis reumatoide

Mora ATT, Andrade OL, Bourlon CRA

Idioma: Español
Referencias bibliográficas: 89
Paginas: 259-268
Archivo PDF: 175.21 Kb.


RESUMEN

La artritis reumatoide es una enfermedad crónica, sistémica, inflamatoria, de origen autoinmunitario, que frecuentemente produce deformación y destrucción de las articulaciones y se asocia con discapacidad física y morbilidad psicosocial. El tratamiento temprano y agresivo de la enfermedad es decisivo para evitar la progresión y destrucción de las articulaciones. Los medicamentos biológicos representan una opción terapéutica muy efectiva, con efectos adversos tolerables. Este grupo de medicamentos ha demostrado disminuir de manera importante la inflamación, inhibir la progresión radiográfica e inducir remisión. En este artículo se revisan: la farmacocinética, los efectos biológicos y los estudios que han demostrado la eficacia y seguridad de los agentes biológicos indicados como monoterapia y tratamiento combinado.


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