2008, Número 6
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Med Int Mex 2008; 24 (6)
Preeclampsia y desequilibrio del estado óxidoreducción. Papel de los antioxidantes
Duarte MJ, Espinosa LRF, Díaz MS, Sánchez RG, Lee Eng CVE, Díaz CIA
Idioma: Español
Referencias bibliográficas: 24
Paginas: 407-413
Archivo PDF: 213.43 Kb.
RESUMEN
La hipertensión arterial complica 5 a 10% de los embarazos y es la mayor causa de morbilidad y mortalidad matero-infantil. La preeclampsia es un problema hipertensivo del embarazo cuyas características sobresalientes son la implantación superficial y la inadecuada perfusión placentaria que está unida al aumento del estrés oxidativo. Los antioxidantes son importantes para mantener la integridad celular en un embarazo normal, al inhibir las reacciones de peroxidación y con ello proteger las enzimas, proteínas y células de la destrucción por peróxidos.
REFERENCIAS (EN ESTE ARTÍCULO)
American College of Obstetricians and Gynecologists. Clinical management guidelines for obstetrician-gynecologists: diagnosis and management of preeclampsia and eclampsia: ACOG practice bulletin no. 33. Obstet. Gynecol 2002;99:159- 61.
Sladek SM, Magness RR, Conrad KP. Nitric oxide and pregnancy. Am J Physiol 1997;272:R441-63.
Khalil RA, Granger JP. Vascular mechanisms of increased arterial pressure in preeclampsia: lessons from animal models. Am J Physiol Regul Integr Comp Physiol 2002;283:R29-45.
Paul DS. Elevated asymmetric dimethylarginine concentrations precede clinical preeclampsia, but not pregnancies with small-for-gestational-age infants Am J Obstet Gynecol 2008;198:112.e1-112.e7.
Fangxian L. The effect of over-expression of sFlt-1 on blood pressure and the occurrence of other manifestations of preeclampsia in unrestrained conscious pregnant mice. Am J Obstet Gynecol 2007;396e1-396e7.
Vaughn CJ, Delanty N. Hypertensive emergencies. Lancet 2000;356:411-7.
Aggarwal M. Hypertensive crisis: Hypertensive emergencies and urgencies. Cardiol Clin 2006;24:135-46.
Caren GS. Hypertension in pregnancy. Endocrinol Metab Clin N Am 2006;35:157-71.
Seongho R. Increased leukocyte adhesion to vascular endothelium in preeclampsia is inhibited by antioxidants. Am J Obstet Gynecol 2007;196:400.e1-400.e8.
Cooke JP. Does ADMA cause endothelial dysfunction? Arterioscler Thromb Vasc Biol 2000;20:2032-37.
Cooke JP. Asymmetrical dimethylarginine: the Upper marker? Circulation 2004; 109:1813-8.
Holden DP, Fickling SA, Whitley GS, Nussey SS. Plasma concentrations of asymmetric dimethylarginine, a natural inhibitor of nitric oxide synthase, in normal pregnancy and preeclampsia. Am J Obstet Gynecol 1998;178:551-6.
Pettersson A, Hedner T, Milsom I. Increased circulating concentrations of asymmetric dimethyl arginine (ADMA), an endogenous inhibitor of nitric oxide synthesis, in preeclampsia. Acta Obstet Gynecol Scand 1998;77:808-13.
Savvidou MD, Hingorani AD, Tsikas D, Frolich JC, Vallance P, Nicolaides KH. Endothelial dysfunction and raised plasma concentrations of asymmetric dimethylarginine in pregnant women who subsequently develop preeclampsia. Lancet 2003;361:1511-7.
Levine RJ, Maynard SE, Qian C, et al. Circulating angiogenic factors and the risk of preeclampsia. N Engl J Med 2004;350:672-83.
Cooke JP. NO and angiogenesis. Atheroscler Suppl 2003;4:53-60.
Fukumura D, Gohongi T, Kadambi A, et al. Predominant role of endothelial nitric oxide synthase in vascular endothelial growth factor-induced angiogenesis and vascular permeability. Proc Natl Acad Sci USA 2001;98:2604-9.
Teerlink T, Nijveldt RJ, de Jong S, van Leeuwen PA. Determination of arginine, asymmetric dimethylarginine, and symmetric dimethylarginine in human plasma and other biological samples by high-performance liquid chromatography. Anal Biochem 2002;303:131-7.
Arun J. Antioxidants and the Prevention of Preeclampsia -Unresolved Issues. N Engl J Med 2005;354(17):1841-43.
Carbonne B. Successful pregnancy with the use of nitric oxide donors and heparin after recurrent severe preeclampsia in a woman with scleroderma. Am J Obstet Gynecol 2007;e6- e7.
Chappell LC, Seed PT, Briley AL, et al. Effect of antioxidants on the occurrence of pre-eclampsia in women at increased risk: a randomized trial. Lancet 1999;354:810-6.
Beazley D, Ahokas R, Livingston J, Griggs M, Sibai BM. Vitamin C and E supplementation in women at high risk for preeclampsia: a double-blind, placebo-controlled trial. Am J Obstet Gynecol 2005;192:520-1.
Poston L, Briley AL, Seed PT, Kelly FJ, Shennan AH. Vitamin C and vitamin E in pregnant women at risk for pre-eclampsia (VIP trial): randomized placebo-controlled trial. Lancet; 2006;367:1145-54.
Subhasis B. Is vitamin E a safe prophylaxis for preeclampsia? Am J Obstet Gynecol 2006;194:1228-33.