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2010, Número 1

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Alerg Asma Inmunol Pediatr 2010; 19 (1)


Papel del sistema inmune en la patogenia de la infección por el virus del dengue

Pérez BY

Idioma: Español
Referencias bibliográficas: 86
Paginas: 23-29
Archivo PDF: 77.47 Kb.


RESUMEN

La infección por el virus del dengue (DV) es una seria causa de morbilidad y mortalidad en la mayoría de las áreas tropicales y subtropicales del mundo. La infección puede ser asintomática o causar dos formas de la enfermedad, la fiebre del dengue (DF) o la fiebre hemorrágica del dengue (DHF), la cual es la forma más severa de la enfermedad y a menudo fatal. En infecciones secundarias con un serotipo diferente de DV la severidad de la enfermedad está relacionada con altos niveles de anticuerpos potenciadores y replicación viral en etapas tempranas de la infección, la cual es seguida de la activación de linfocitos T de memoria y otras células del sistema inmune y la producción de citocinas inflamatorias y otros mediadores químicos que causan el incremento de la permeabilidad capilar. Los avances en este campo de la inmunología han demostrado que la patogénesis del DHF/DSS es un proceso complejo y multifactorial relacionado con los factores virales y del hospedero.


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