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2009, Número 2

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Rev Inst Nal Enf Resp Mex 2009; 22 (2)


La inhibición de la cinasa de Rho como posible terapia de la hiperreactividad bronquial

Sommer B, Carbajal V

Idioma: Español
Referencias bibliográficas: 53
Paginas: 101-108
Archivo PDF: 85.26 Kb.


RESUMEN

La contracción del músculo liso de las vías aéreas en respuesta a diversos estímulos disminuye el diámetro de las vías aéreas y en enfermedades como el asma reviste importancia, pues esta contracción se exacerba. Una de las líneas de estudio que busca documentar la posible alteración en la contracción del músculo liso de las vías aéreas en los asmáticos se refiere a la vía de señalización intracelular mediada por la proteína G monomérica Rho y su principal cinasa efectora (ROCK). Este artículo refiere algunos indicios que apuntan a que la inhibición farmacológica de esta vía de señalización tendría potencial terapéutico.


REFERENCIAS (EN ESTE ARTÍCULO)

  1. Chiba Y, Misawa M. The role of RhoA-mediated Ca2+ sensitization of bronchial smooth muscle contraction in airway hyperresponsiveness. J Smooth Muscle Res 2004;40:155-167.

  2. Lambert RK, Wiggs BR, Kuwano K, Hogg JC, Paré PD. Functional significance of increased airway smooth muscle in asthma and COPD. J Appl Physiol 1993;74:2771-2781.

  3. Macklem PT. A theoretical analysis of the effect of airway smooth muscle load on airway narrowing. Am J Respir Crit Care Med 1996;153:83-89.

  4. Halayko AJ, Camoretti-Mercado B, Forsythe SM, et ál. Divergent differentiation paths in airway smooth muscle culture: induction of functionally contractile myocytes. Am J Physiol 1999;276:L197-L206.

  5. Ma X, Cheng Z, Kong H, et ál. Changes in biophysical and biochemical properties of single bronchial smooth muscle cells from asthmatic subjects. Am J Physiol Lung Cell Mol Physiol 2002;283:L1181-L1189.

  6. Pfitzer G. Invited review: regulation of myosin phosphorylation in smooth muscle. J Appl Physiol 2001;91:497-503.

  7. Somlyo AP, Somlyo AV. Ca2+ sensitivity of smooth muscle and nonmuscle myosin II: modulated by G proteins, kinases, and myosin phosphatase. Physiol Rev 2003;83:1325-1358.

  8. Kimura K, Ito M, Amano M, et ál. Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase). Science 1996;273:245-248.

  9. Lutz S, Freichel-Blomquist A, Yang Y, et ál. The guanine nucleotide exchange factor p63RhoGEF, a specific link between Gq/11-coupled receptor signaling and RhoA. J Biol Chem 2005;280:11134-11139.

  10. Janssen LJ, Killian K. Airway smooth muscle as a target of asthma therapy: history and new directions. Respir Res 2006;7:123-134.

  11. Fukata Y, Amano M, Kaibuchi K. Rho-Rho-kinase pathway in smooth muscle contraction and cytoskeletal reorganization of non-muscle cells. Trends Pharmacol Sci 2001;22:32-39.

  12. Amano M, Fukata Y, Kaibuchi K. Regulation and functions of Rho-associated kinase. Exp Cell Res 2000;261:44-51.

  13. Gosens R, Schaafsma D, Grootte Bromhaar MM, et ál. Growth factor-induced contraction of human bronchial smooth muscle is Rho-kinase-dependent. Eur J Pharmacol 2004;494:73-76.

  14. Janssen LJ, Tazzeo T, Zuo J, Pertens E, Keshavjee S. KCl evokes contraction of airway smooth muscle via activation of RhoA and Rho-kinase. Am J Physiol Lung Cell Mol Physiol 2004;287:L852-L858.

  15. Janssen LJ, Wattie J, Lu-Chao H, Tazzeo T. Muscarinic excitation-contraction coupling mechanisms in tracheal and bronchial smooth muscles. J Appl Physiol 2001;91:1142-1151.

  16. Sommer B, Montaño LM, Carbajal V, et ál. Extraction of membrane cholesterol disrupts caveolae and impairs serotonergic (5-HT2A) and histaminergic (H1) responses in bovine airway smooth muscle: role of Rho-kinase. Can J Physiol Pharmacol 2009;87:180-195.

  17. Ammit AJ, Armour CL, Black JL. Smooth-muscle myosin light-chain kinase content is increased in human sensitized airways. Am J Respir Crit Care Med 2000;161:257-263.

  18. Chiba Y, Takada Y, Miyamoto S, Mitsui Saito M, Karaki H, Misawa M. Augmented acetylcholine-induced, Rho-mediated Ca2+ sensitization of bronchial smooth muscle contraction in antigen-induced airway hyperresponsive rats. Br J Pharmacol 1999;127:597-600.

  19. Schaafsma D, Gosens R, Bos IS, Meurs H, Zaagsma J, Nelemans SA. Allergic sensitization enhances the contribution of Rho-kinase to airway smooth muscle contraction. Br J Pharmacol 2004;143:477-484.

  20. Uehata M, Ishizaki T, Satoh H, et ál. Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension. Nature 1997;389:990-994.

  21. Ishizaki T, Uehata M, Tamechika I, et ál. Pharmacological properties of Y-27632, a specific inhibitor of rho-associated kinases. Mol Pharmacol 2000;57: 976-983.

  22. Sasaki Y, Suzuki M, Hidaka H. The novel and specific Rho-kinase inhibitor (S)-(+)-2-methyl-1-[(4-methyl-5-isoquinoline)sulfonyl]-homopiperazine as a probing molecule for Rho-kinase-involved pathway. Pharmacol Ther 2002;93:225-232.

  23. Yoshii A, Iizuka K, Dobashi K, et ál. Relaxation of contracted rabbit tracheal and human bronchial smooth muscle by Y-27632 through inhibition of Ca2+ sensitization. Am J Respir Cell Mol Biol 1999;20:1190-1200.

  24. Suzuki Y, Shibuya M, Satoh S, Sugiyama H, Seto M, Takakura K. Safety and efficacy of fasudil monotherapy and fasudil-ozagrel combination therapy in patients with subarachnoid hemorrhage: sub-analysis of the post-marketing surveillance study. Neurol Med Chir (Tokyo) 2008;48:241-247.

  25. Otsuka T, Ibuki C, Suzuki T, et ál. Administration of the Rho-kinase inhibitor, fasudil, following nitroglycerin additionally dilates the site of coronary spasm in patients with vasospastic angina. Coron Artery Dis 2008;19:105-110.

  26. Fukumoto Y, Mohri M, Inokuchi K, et ál. Anti-ischemic effects of fasudil, a specific Rho-kinase inhibitor, in patients with stable effort angina. J Cardiovasc Pharmacol 2007;49:117-121.

  27. Hinderling PH, Karara AH, Tao B, Pawula M, Wilding I, Lu M. Systemic availability of the active metabolite hydroxy-fasudil after administration of fasudil to different sites of the human gastrointestinal tract. J Clin Pharmacol 2007;47:19-25.

  28. Li F, Xia W, Yuan S, Sun R. Acute inhibition of Rho-kinase attenuates pulmonary hypertension in patients with congenital heart disease. Pediatr Cardiol 2009;30:363-366.

  29. Shibuya M, Suzuki Y, Sugita K, et ál. Dose escalation trial of a novel calcium antagonist, AT877, in patients with aneurysmal subarachnoid haemorrhage. Acta Neurochir (Wien) 1990;107:11-15.

  30. Shibuya M, Suzuki Y, Sugita K, et ál. Effect of AT877 on cerebral vasospasm after aneurysmal subarachnoid hemorrhage. Results of a prospective placebo-controlled double-blind trial. J Neurosurg 1992;76:571-577.

  31. Vicari RM, Chaitman B, Keefe D, et ál; Fasudil Study Group. Efficacy and safety of fasudil in patients with stable angina: a double-blind, placebo-controlled, phase 2 trial. J Am Coll Cardiol 2005;46:1803-1811.

  32. Masumoto A, Mohri M, Shimokawa H, Urakami L, Usui M, Takeshita A. Suppression of coronary artery spasm by a Rho-kinase inhibitor fasudil in patients with vasospastic angina. Circulation 2002;105:1545-1547.

  33. Mohri M, Shimokawa H, Hirakawa Y, Masumoto A, Takeshita A. Rho-kinase inhibition with intracoronary fasudil prevents myocardial ischemia in patients with coronary microvascular spasm. J Am Coll Cardiol 2003;41:15-19.

  34. Inokuchi K, Ito A, Fukumoto Y, et ál. Usefulness of fasudil, a Rho-kinase inhibitor, to treat intractable severe coronary spasm after coronary artery bypass surgery. J Cardiovasc Pharmacol 2004;44:275-277.

  35. Fukumoto Y, Matoba T, Ito A, et ál. Acute vasodilator effects of a Rho-kinase inhibitor, fasudil, in patients with severe pulmonary hypertension. Heart 2005;91:391-392.

  36. Shibuya M, Hirai S, Seto M, Satoh S, Ohtomo E; Fasudil Ischemic Stroke Study Group. Effects of fasudil in acute ischemic stroke: results of a prospective placebo-controlled double-blind trial. J Neurol Sci 2005;238:31-39.

  37. Kishi T, Hirooka Y, Masumoto A, et ál. Rho-kinase inhibitor improves increased vascular resistance and impaired vasodilation of the forearm in patients with heart failure. Circulation 2005;111:2741-2747.

  38. Nagaoka T, Fagan KA, Gebb SA, et ál. Inhaled Rho kinase inhibitors are potent and selective vasodilators in rat pulmonary hypertension. Am J Respir Crit Care Med 2005;171:494-499.

  39. Iizuka K, Shimizu Y, Tsukagoshi H, et ál. Evaluation of Y-27632, a Rho-kinase inhibitor, as a bronchodilator in guinea pigs. Eur J Pharmacol 2000;406:273-279.

  40. Liu C, Tazzeo T, Janssen LJ. Isoprostane-induced airway hyperresponsiveness is dependent on internal Ca2+ handling and Rho/ROCK signaling. Am J Physiol Lung Cell Mol Physiol 2006;291:L1177-L1184.

  41. Hashimoto T, Nakano Y, Yamashita M, Fang YI, Ohata H, Momose K. Role of Rho-associated protein kinase and histamine in lysophosphatidic acid-induced airway hyperresponsiveness in guinea pigs. Jpn J Pharmacol 2002;88:256-261.

  42. Bousquet J, Jeffery PK, Busse WW, Johnson M, Vignola AM. Asthma. From bronchoconstriction to airways inflammation and remodeling. Am J Respir Crit Care Med 2000;161:1720-1745.

  43. Gleich GJ, Flavahan NA, Fujisawa T, Vanhoutte PM. The eosinophil as a mediator of damage to respiratory epithelium: a model for bronchial hyperreactivity. J Allergy Clin Immunol 1988;81:776-781.

  44. Costello RW, Jacoby DB, Gleich GJ, Fryer AD. Eosinophils and airway nerves in asthma. Histol Histopathol 2000;15:861-868.

  45. Lee JJ, Dimina D, Macias MP, et ál. Defining a link with asthma in mice congenitally deficient in eosinophils. Science 2004;305:1773-1776.

  46. Adachi T, Vita R, Sannohe S, et ál. The functional role of rho and rho-associated coiled-coil forming protein kinase in eotaxin signaling of eosinophils. J Immunol 2001;167:4609-4615.

  47. Henry PJ, Mann TS, Goldie RG. A rho kinase inhibitor, Y-27632 inhibits pulmonary eosinophilia, bronchocon striction and airways hyperresponsiveness in allergic mice. Pulm Pharmacol Ther 2005;18:67-74.

  48. Saito H, Minamiya Y, Saito S, Ogawa J. Endothelial Rho and Rho kinase regulate neutrophil migration via endothelial myosin light chain phosphorylation. J Leukoc Biol 2002;72:829-836.

  49. Wettschureck N, Offermanns S. Rho/Rho-kinase mediated signaling in physiology and pathophysiology. J Mol Med 2002;80:629-638.

  50. Chiba Y, Sakai H, Misawa M. Augmented acetylcholine-induced translocation of RhoA in bronchial smooth muscle from antigen-induced airway hyperresponsive rats. Br J Pharmacol 2001;133:886-890.

  51. Chiba Y, Arima J, Sakai H, Misawa M. Lovastatin inhibits bronchial hyperresponsiveness by reducing RhoA signaling in rat allergic asthma. Am J Physiol Lung Cell Mol Physiol 2008;294:L705-L713.

  52. Takeda N, Kondo M, Ito S, Ito Y, Shimokata K, Kume H. Role of RhoA inactivation in reduced cell proliferation of human airway smooth muscle by simvastatin. Am J Respir Cell Mol Biol 2006;35:722-729.

  53. Hirst SJ. Airway smooth muscle as a target in asthma. Clin Exp Allergy 2000;30 Suppl 1:54-59.




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