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ISSN 0187-5337 (Impreso)
Instituto Nacional de Perinatología

2002, Número 3

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Perinatol Reprod Hum 2002; 16 (3)


Papel de los anticuerpos en el desarrollo de la infección por Chlamydia trachomatis y su utilidad en el diagnóstico

López-Hurtado M, Guerra-Infante FM

Idioma: Español
Referencias bibliográficas: 49
Paginas: 140-150
Archivo PDF: 119.10 Kb.


RESUMEN

Las bacterias del género Chlamydia se caracterizan por ser patógenos intracelulares que causan una amplia variedad de padecimientos, tanto en el hombre como en los animales. La respuesta inmunológica humoral ha sido considerada como no útil contra patógenos intracelulares. Sin embargo, hay evidencias convincentes de que los anticuerpos pueden proteger contra muchos de los microorganismos intracelulares o de sus productos. El reto actual es identificar qué antígenos pueden ser útiles para el desarrollo de anticuerpos y vacunas. El objetivo de esta revisión bibliográfica es conocer cómo los anticuerpos anti Chlamydia participan en la protección y en el diagnóstico de la enfermedad.


REFERENCIAS (EN ESTE ARTÍCULO)

  1. Cates W, Wasserheit J. Genital chlamydial infections: Epidemiology and reproductive sequelae. Am J Obstet Gynecol 1991; 164 (6 Pt2): 1771-81.

  2. Stam W E. Chlamydia trachomatis infections: Progress and problems. J Infect Dis 1999: 179 (Suppl 2): S380-3.

  3. Curran JW. Economic consequences of pelvic inflammatory disease in the United States. Am J Obstet Gynecol 1980; 138(7 Pt2): 848-51.

  4. Centers for Disease Control: Pelvic inflammatory disease: guidelines for prevention and management. Morb Mortal Wkly Rep 1991; 40: 1-25.

  5. Sieper J, Kingsley G. Recent advances in the pathogenesis of reactive arthritis. Immunol Today 1996; 17: 160-3.

  6. Ewald PW, Cochran GM. Chlamydia pneumoniae and cardiovascular disease: An evolutionary perspective in infectious causation and antibiotic treatment. J Infect Dis 2000; 181 (Suppl 3): S394-401.

  7. Cacho J, Sanz F, Blanco MA. La enfermedad silenciosa por Chlamydia trachomatis: necesidad urgente de detección y tratamiento en mujeres. Enferm Infecc Microbiol Clin 2001; 19: 419-21.

  8. Kiviat NB, Peterson M, Kinney-Thomas E, Tam M, Stamm WE, Holmes KK. Cytologic manifestations of cervical and vaginal infections. II. Confirmation of Chlamydia trachomatis infection by direct immunofluorescence using monoclonal antibodies. JAMA 1985; 253: 997-1000.

  9. Guerra-Infante FM, López-Hurtado M. Mecanismos inespecíficos en la eliminación de Chlamydia trachomatis. Perinatol Reprod Hum 1999; 13: 205-13.

  10. Guerra-Infante FM, Arredondo-García JL. Mecanismos inmunológicos en las enfermedades infecciosas. Perinatol Reprod Hum 1994; 8:12-9.

  11. Mosmann TR, Sad S. The expanding universe of T-cell subsets: Th1, Th2, and more. Immunol Today 1996; 17: 138-46.

  12. Stephens RS. Molecular mimicry and Chlamydia trachomatis infection of eukaryotic cells. Trends Microbiol 1994; 2: 99-101.

  13. Bavoil PM. Determinants of chlamydial pathogenesis and immunity. In: Molecular genetics of bacterial pathogenesis. Miller VL, Kaper JB, Portnoy DA, Isberg RR. (Eds). Washington: American Society for Microbiology; 1994, p. 295-308.

  14. Christiansen G, Boesen T, Hjernø K, Daugaard L, Mygind P, Madsen AS, Knudsen K, Falk E, Birkelund S. Molecular biology of Chlamydia pneumoniae surface proteins and their role in immunopathogenicity. Am Heart J 1999; 138: S491-5.

  15. Birkelund S, Mygind P, Holm A, Larsen B, Beck F, Christiansen G. Characterization of two conformational epitopes of the Chlamydia trachomatis serovar L2 DnaK immunogen. Infect Immun 1996; 64: 810-7.

  16. Brunham RC, Kuo CC, Cles L, Holmes KK. Correlation of host immune response with quantitative recovery of Chlamydia trachomatis from human endocervix. Infect Immun 1983; 39: 1491-4

  17. Rank R. Role of the immune response. In: Microbiology of Chlamydia. Boca Raton, Florida: Barron AL (Eds). CRC Press; 1988, p. 218-34.

  18. Casadevall A. Antibody-mediated protection against intracellular pathogens. Trends Microbiol 1998; 6: 102-7.

  19. Lan J, Walboomers JMM, Roosendaal R, van Doornum GJJ, MacLaren DM, Meijer LM, van den Brule AJC. Direct detection and genotyping of Chlamydia trachomatis in cervical scrapes by using polymerase chain reaction and restriction fragment length polymorphism analysis. J Clin Microbiol 1993; 31: 1060-5.

  20. Wang SP, Grayston JT. Immunologic relationship between genital TRIC, lymphogranuloma venereum, and related organisms in a new microtiter indirect immunofluorescence test. Am J Ophthalmol 1970; 70: 367-74.

  21. Sothard DR, Boguslawski G, Jones RB. Phylogenetic analysis of the Chlamydia trachomatis major outer membrane protein and examination of potential pathogenic determinants. Infect Immun 1998; 66: 3618-25.

  22. Cerrone MC, Jeffrey JMA, Stephens RS. Cloning and sequence of the gene for heat shock protein 60 from Chlamydia trachomatis and immunological reactivity of the protein. Infect Immun 1991; 69: 79-90.

  23. Witkin SS, Jeremias J, Toth M, Ledger WJ. Cell-mediated immune response to the recombinant 57-kDa heat-shock protein of Chlamydia trachomatis in women with salpingitis. J Infec Dis 1993; 167: 1379-83.

  24. Dieterle S, Wollenhaupt J. Humoral immune response to the chlamydial heat shock proteins hsp60 and hsp70 in Chlamydia-associated chronic salpingitis with tubal occlusion. Hum Reprod 1996; 11: 1352-6.

  25. De Haro-Cruz MJ, Flores-Medina S, Zamora-Ruiz A, López-Hurtado M, Guerra-Infante FM. Presencia de anticuerpos antiproteínas de útero en suero de pacientes con problemas ginecológicos. An Esc Nac Cienc Biol Méx 1999; 45: 37-50.

  26. Witkin SS, Ledger WJ. Antibodies to Chlamydia trachomatis in sera of women with recurrent spontaneous abortion. Am J Obstet Gynecol 1992; 167: 135-9.

  27. Williams DM. Stimulation of immune response. In: Microbiology of Chlamydia. Barron AL (Eds). Boca Raton, Florida: CRC Press; 1988, p. 209-16.

  28. Batteiger BE, Rank RG. Analysis of the humoral immune response to chlamydial genital infections in guinea pigs. Infect Immun 1987; 55: 1767-73.

  29. Rank RG, Barron AL. Humoral immune response in acquired immunity to chlamydial genital infection of female guinea pigs. Infect Immun 1983; 39: 463-5.

  30. Ramsey KH, Soderberg LSF, Rank RG. Resolution of Chlamydial genital infection in B-cell-deficient mice and immunity to reinfection. Infect Immun 1988; 56: 1320-5.

  31. Su H, Feilzer K, Caldwell HD, Morrison RP. Chlamydia trachomatis genital tract infection of antibody-deficient gene knockout mice. Infect Immun 1997; 65: 1993-9.

  32. Brade H, Brunner H. Serological crossreactions between Acinetobacter calcoaceticus and Chlamydiae. J Clin Microbiol 1979; 10: 819-23.

  33. Brade L, Nano FE, Schlecht S, Schramek and Brade H. Antigenic and immunogenic properties or recombinants from Salmonella typhimurium and Salmonella minnesota rough mutants expressing in their lipopolysaccharide a genus-specific chlamydial epitopes. Infect Immun 1987; 55: 482-6.

  34. Maurin M, EB F, Etienne J, Raoult D. Serological cross-reaction between Bartonella and Chlamydia species: implications for diagnosis. J Clin Microbiol 1997; 35: 2283-6.

  35. Lahesmaa-Rantala R, Stahlberg TH, Granfors K, Kuusisto P, Toivanen A. Serological cross-reactions against Yersinia enterocolitica in patients infected with other arthritis-associated microbes. Clin Exp Rheumatol 1990; 8: 5-9.

  36. Rivera-Méndez M. Guerra-Infante FM, Hernández-Méndez JT, Sumano-Avendaño E. Presencia de anticuerpos IgA anti Chlamydia con reactividad cruzada a otros microorganismos. XXV Congreso Anual de la Asociación Mexicana de Infectología y Microbiología Clínica. Enferm Infecc Microbiol Clin 2000 (Suppl); 20: 10.

  37. Black CM. Current methods of laboratory diagnosis of Chlamydia trachomatis infections. Clin Microbiol Rev 1997; 10: 160-84.

  38. Land JA, Evers JLH, Goossens VJ. How to use Chlamydia antibody testing in subfertility patients. Hum Reprod 1998; 13: 1094-8.

  39. Thomas K, Coughlin L, Mannion PT, Haddad NG. The value of Chlamydia trachomatis antibody testing as part of routine infertility investigations. Hum Reprod 2000; 15: 1079-82.

  40. Mol BWJ, Collins JA, Van der Veen F, Bossuyt PMM. Cost-effectiveness of hysterosalpingography, laparoscopy and Chlamydia antibody testing in subfertile couples. Fertil Steril 2001; 75: 571-80.

  41. Schachter J, Dawson CR (Eds). Laboratory diagnosis. In: Human Chlamydial infections. Massachusetts: PSG Publishing Company, Littleton; 1978, p. 181-220.

  42. Tanikawa M, Harada T, Katagiri C, Onohara Y, Yoshida S, Terakawa N. Chlamydia trachomatis antibody titres by enzymelinked immunosorbent assay are useful in predicting severity of adnexal adhesion. Hum Reprod 1996; 11: 2418-21.

  43. Mattila A, Miettinen A, Heinonen PK, Teisala K, Punnonen R, Paavonen J. Detection of serum antibodies to Chlamydia trachomatis in patients with chlamydial and Nonchlamydial pelvic inflammatory disease by the IPAzyme Chlamydia and enzyme immunoassay. J Clin Microbiol 1993; 31: 998-1000.

  44. Chernesky M, Luinstra K, Sellors J, Schachter J, Moncada J, Caul O, Paul I, Mikaelian L, Toye B, Paavonen J, Mahony J. Can serology diagnose upper genital tract Chlamydia trachomatis infection? Sex Transm Dis 1998; 25: 14-9.

  45. Kaltenboeck B, Heard D, DeGraves FJ, Schmeer N. Use of synthetic antigens improves detection by enzyme-linked immunosorbent assay of antibodies against abortigenic Chlamydia psittaci in ruminants. J Clin Microbiol 1997; 35: 2293-8.

  46. Bas S, Muzzin P, Ninet B, Bornand JE, Scieux C, Vischer TL. Chlamydial serology: comparative diagnostic value of immunoblotting, microimmunofluorescence test, and immunoassay using different recombinant proteins as antigens. J Clin Microbiol 2001; 39: 1368-77.

  47. Tuuminen T, Varjo S, Ingman H, Weber T, Oksi J, Viljanen M. Prevalence of Chlamydia pneumoniae and Mycoplasma pneumoniae immunoglobulin G and A antibodies in a healthy Finnish population as analyzed by quantitative enzyme immunoassays. Clin Diag Lab Immunol 2000; 7: 734-8.

  48. Hubacher D, Lara-Ricalde R, Taylor DJ, Guerra-Infante F, Guzmán-Rodríguez R. Use of cooper intrauterine devices and the risk of tubal infertility among nulligravid women. New Eng J Med 2001; 345: 561-7.

  49. Guerra-Infante FM, Carballo-Perea R, López-Hurtado M, Zamora-Ruiz A, Flores- Medina S. Evaluación de la prueba serológica de inmunofluorescencia indirecta (IFA) anti Chlamydia trachomatis para el diagnóstico de infertilidad por factor tubárico en mujeres mexicanas. X Congreso de la Asociación Panamericana de Infectología. Enferm Infecc Microbiol Clin 2001 (Suppl); 21: S145.




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