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ISSN 0187-5337 (Impreso)
Instituto Nacional de Perinatología

2008, Número 4

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Perinatol Reprod Hum 2008; 22 (4)


Efecto de los donadores de óxido nítrico en la inducción de la maduración cervical

Arteaga-Troncoso G, López-Hurtado M, Guerra-Infante F

Idioma: Español
Referencias bibliográficas: 96
Paginas: 303-314
Archivo PDF: 357.86 Kb.


RESUMEN

Los nitratos orgánicos o ésteres del ácido nítrico, tales como el dinitrato de isosorbide, trinitrato de glicerilo y nitroprusiato de sodio, son una nueva clase de compuestos utilizados para inducir la maduración cervical. Su eficacia se basa en la capacidad que tienen para ser bioactivados en el sistema de óxido nítrico para relajar al músculo liso vascular. Los experimentos químicos han implicado tanto a las riboflavinas como a los tioles en la activación de los nitratos orgánicos. Aunque existe una gran cantidad de estudios biológicos que sugieren que el óxido nítrico puede formarse a partir de los nitratos orgánicos en el medio ambiente intracelular, el mecanismo químico de las células endoteliales de cuello uterino, mediante el cual ocurre, aún no se ha establecido. En este artículo se revisan las posibles interacciones entre los nitratos orgánicos, flavinas y tioles, como un medio para determinar el papel que pueden desempeñar estas especies bioquímicas en la producción de óxido nítrico y la maduración cervical.


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