2008, Número 1
<< Anterior Siguiente >>
Perinatol Reprod Hum 2008; 22 (1)
Fenómenos de la “programación” in utero: efectos del alto nivel de estrés y de la desnutrición durante el embarazo
Maldonado-Durán JM, Lartigue T
Idioma: Español
Referencias bibliográficas: 69
Paginas: 26-35
Archivo PDF: 308.10 Kb.
RESUMEN
El artículo revisa la evidencia científica respecto a los “efectos de programación” de la exposición
in utero a experiencias adversas. Éstos ocurren en el metabolismo y conducta del feto, el niño y tienen efectos a largo plazo en el adulto. Un nivel elevado de estrés psicosocial en la madre da lugar a resultados obstétricos negativos y efectos adversos en la conducta del niño. Se revisan los efectos de la desnutrición intrauterina y del bebé de bajo peso para su edad gestacional en términos del síndrome X (diabetes, hipertensión, enfermedad isquémica cardiaca y obesidad), así como la posible predisposición a depresión y otros trastornos mentales en la edad adulta. Estos estados son prevenibles y una intervención temprana podría aliviar esos efectos negativos.
REFERENCIAS (EN ESTE ARTÍCULO)
Alvarado R, Medina E, Aranda W. Componentes psicosociales del riesgo durante la gestación. Revisión bibliográfica. Rev Psiquiatría 1996; 13: 30-41.
Kennel JH, McGrath SK. Commentary: practical and humanistic lessons from the third world for caregivers everywhere. Birth 1999; 26: 9-10.
Maldonado-Durán JM, Lartigue T, Feintuch M. Perinatal Psychiatry: Infant mental health interventions during pregnancy. Bull Menninger Clin 2000; 64: 317-43.
Hobel C , Culhane J . Ro l e of psychosocial and nutritional stress on poor pregnancy outcome. J Nutr 2003; 133: S1709-S17.
Zapata BC, Rebolledo A, Atalah E, Newman B, King, MC. The influence of social and political violence on the risk of pregnancy complications. Am J Pub Health 1992; 82: 685-90.
Grjibovski A, Bygren LO, Svartbo B, Magnus P. Housing conditions, perceived stress, smoking, and alcohol: determinants of fetal growth in Northwest Russia. Acta Obstet Gynecol Scand 2004; 83(12):1159-66.
Barker DJP, Forsén T, Uutela A, Osmond C, Eriksson JG. Size at birth and resilience to effects of poor living conditions in adult life: longitudinal study. Br Med J 2001: 323: 3281-5.
Grammer K, Schreiner S, Artzmuller M, Dittami J. Die evolutionäre Psychologie des Kindes: Soziale Intelligenz und Überleben [La psicología evolutiva del niño. Inteligencia social y supervivencia]. En: Alt KW, Kemkes-Grottenhaler (eds.). Kinderwelten [Los mundos de los niños]. Colonia: Bohlau Verlag; 2002, p. 6-23.
Coussons-Read M, Okun M, Simms S. The pychoneuroimmunology of pregnancy. J Reproduc Infant Psychol 2003; 21: 103-12
Althabe F, Carroli G, Lede R, Belizán JM, Althabe OH. El parto pretérmino: detección de riesgos y tratamientos preventivos. Rev Panam Salud Pública 1999; 5: 373-85.
Rauchfuss M, Gauger U. Vorzeitige Wehen und Frühgeburt, eine psychosomatische Störung? Ergebnisse einer prospectiven Studie [Trabajo de parto y parto prematuro, ¿es un trastorno psicosomático? Resultados de un estudio prospectivo]. Zentralbl Gynakol 2003: 125: 167-78.
Dole N, Savits DA, Hertz-Picciotto, Siega- Riz AM, McMahon MJ, Buekens P. Maternal stress and preterm birth. Am J Epidemiol 2003; 157(1): 14-24.
Alvarado R, Medina E, Aranda W. El efecto de variables psicosociales durante el embarazo, en el peso y la edad gestacional del recién nacido. Rev Med Chil 2002; 130: 561-8.
Copper RL, Goldernberg RL, Das A, Elder N, Swain M, et al. The preterm prediction study: maternal stress is associated with spontaneous preterm birth at less than thirty five weeks’ gestation. Am J Obstet Gynecol 1996; 175: 1286-92.
Lou HC, Hansen D, Nordentoft M, Pryds O, Jensen F, Nim J, Hemmingsen R. Prenatal stressors of human life affect fetal brain development. Dev Med Child Neurol 1994; 36: 826-32.
Weinstock M. Alterations induced by gestational stress in brain morphology and behavior of the offspring. Prog Neurobiol 2001; 65: 427-51.
Obel C, Hedegaard M, Henriksen TB, Secher NJ, Olsen J. Stressful life events in pregnancy and head circumference at birth. Dev Med Child Neurol 2003; 45: 802-6.
Glynn LM, Wadhwa PD, Dunkel-Schetter C, Chicz-Demet A, Sandman CA. When stress happens matters: Effects of earthquake timing on stress responsivity in pregnancy. Am J Obstet Gynecol 2001; 184: 637-42.
Wadhwa PD, Sandman CA, Porto M, Dunkel-Schetter C, GariteTJ. The association between prenatal stress and infant birth weight and gestational age at birth: a prospective investigation. Am J Obstet Gynecol 1993: 169: 858-65.
Huizink AC, Robles de Medina PG, Mulder EJH, Visser GHA, BuitelaarJK. Stress during pregnancy is associated with developmental outcome in infancy. J Child Psychol Psychiatry 2003; 44: 810-18.
Barker DJP. Mothers, babies and health in later life. Edimburgo: Churchill Livingston; 1998.
Dunger DB, Ong KK. Endocrine and metabolic consequences of intrauterine growth retardation. Endocrinol Metab Clin North Am 2005; 34: 597-615.
Gitau R, Cameron A, Fisk NM, Glover V. Fetal exposure to maternal cortisol. Lancet 1998; 352: 707.
Monk C, Myers MM, Sloan RP, Ellman LM, Fifer WP. Effects of women’s stresselicited physiological activity and chronic anxiety on fetal heart rate. J Develop Behav Pediatr 2003; 24: 32-9.
Uno H, Eisele S, Sakai A, Shelton S, Baker E, DeJesus O, Holden J. Neurotoxicity of glucocorticoids in the primate brain. Horm Beh 1994: 28, 336-48.
DiPietro JA, Hawkins ML, Hilton SC, Costigan KA, Pressman EK. Maternal stress and affect influence fetal neurobehavioral development. Dev Psychol 2002; 38: 659-69.
Groome LJ, Swiber MJ, Bentz LS, Holland SB, Atterbury JL. Maternal anxiety during pregnancy: Effect on fetal behavior at 38 to 40 weeks of gestation. J Develop Behav Pediatr 1995; 16: 391-6.
Sandman CA, Glynn L, Wadhwa PD, Chicz-DeMet A, Porto M, Garite T. Maternal hypothalamic-pituitary-adrenal disregulation during the third trimester influences human fetal responses. Develop Neurosci 2003; 25: 41-9.
Rieger M, Pirke KM, Buske-Kirschbaum A, Wurmser H, Papousek M, Hellhammer DH. Influence of stress during pregnancy on HPA activity and neonatal behavior. Ann N Y Acad Sci 2004; 1032: 228-30.
Van den Bergh B. The influence of maternal emotions during pregnancy on fetal and neonatal behavior. Pre Perinatal Psychol 1990: 5: 119-30.
O’Connor TG, Heron J, Golding J, Glover V. Maternal antenatal anxiety and behavioral/emotional problems in children: a test of a programming hypothesis. J Child Psychol Psychiatry 2003; 44: 1025-36.
O’Connor TG, Heron J, Golding J, Beveridge M, Glover V. Maternal antenatal anxiety and children’s behavioralemotional problems at 4 years. Br J Psychiatry 2002; 180: 502-8.
Pesonen AK, Raikonen K, Kajantie E, Heinonen K, Strandberg TE, Jarvenpaa AL. Fetal programming of temperamental negative affectivity among children born healthy at term. Dev Psychobiol 2006; 33: 731-40.
Foster SM. The effects of maternal stress in pregnancy on sensory integration in children. Journal of Prenatal and Perinatal Psychology and Health 2006; 21: 83-90.
Xiao D, Huan X, Bae S, Cudsay CA, Longo LD, Zhang L. Cortisol-mediated regulation of uterine artery contractility: effect of chronic hypoxia. Am J Physiol Heart Circ Physiol 2004; 286: H716-22.
Linnet KM, Dalsgaard S, Obel C, Wisborg K, Henriksen TB, Rodriguez A, et al. Maternal lifestyle factors in pregnancy risk of attention deficit hyperactivity disorder and associated behaviors. Review of the current evidence. Am J Psychiatry 2003; 160: 1028-40.
Laucht M, Esser G, Baving L, Gerhold M, Howsch I, Ihle W, et al. Behavioral sequelae of perinatal insults and early family adversity at 8 years of age. J Am Acad Child Adol Psychiatry 2002; 39: 1229-37.
Rey J, Bresson JL. Consequences à long terme de la nutrition foetale. [Consecuencias a largo plazo de la nutrición fetal]. Arch Pediatr 1997; 4: 359-66.
Martins EB, Nuñez Urquiza. Consumo calórico, estado nutricional materno, y retraso del crecimiento intrauterino. Cad Saude Publica 2003; 19: 279-85.
Lerner JP. Fetal growth and well-being. Obstet Gynecol Clin North Am 2004; 31: 159-76.
Krishnaswamy K, Naidu AN, Prasad MPR, Reddy GA. Fetal malnutrition and adult chronic disease. Nutr Rev 2002; 60: S35-9.
Mahajan SD, Singh S, Shah P, Gupta N, Kochupillai N. Effect of maternal malnutrition and anemia on the endocrine regulation of fetal growth. Endocr Res 2004; 30: 189-203.
Das UG, Sysyn GD. Abnormal fetal growth:intrauterine growth retardation, small for gestational age, large for gestational age. Ped Clin North Am 2004; 51: 639-54.
Gluckman PD, Cutfield W, Hofman P, Hanson MA. The fetal, neonatal and infant environments, the long term consequences for disease risk. Early Hum Dev 2005; 81: 51-9.
Kramer MS. Determinant of low birth weight: methodological assessment and meta-analysis. Bull World Health Organ 1987; 65: 663-737.
Strauss RD, Dietz WH. Low maternal weight in the second or third trimester increases the risk of intrauterine growth retardation. J Nutrition 1999; 129: 988-93.
Collins JW, David RJ, Prachand NG, Pierce ML. Low birth weight across generations. Matern Child Health J 2003; 7: 229-37.
Klebanoff MA, Meirik O, Berendes HW. Second-generation consequences of smallfor- dates birth. Pediatrics 1989; 84: 343-7.
Lahti J, Raikkonen K, Kajantie E, Heinonen K, Pesonen AK, Jarvenpaa AL, Strandberg T. Small body size at birth and behavioural symptoms of ADHD in children aged five to six years. J Child Adol Psychiatry 2006; 47: 1167-74.
Rassmussen KM. The “fetal origins” hypothesis. Challenges and opportunities for maternal and child nutrition. Annu Rev Nutr 2001; 21: 73-95.
Leon DA, Lithell HO, Vagero D, Koupilovd I, Mohsen R, et al. Reduced fetal growth rate and increased risk of death from ischaemic heart disease: cohort study of 15,000 Swedish men and women born 1915- 29. Br Med J 1998; 317: 241-5.
Levy-Marchal C, Jaquet D. Long-term metabolic consequences of being born small for gestational age. Pediatr Diabetes 2004; 5: 147-53.
Seckl JR. Prenatal glucocorticoids and longterm programming. Eur J Endocrinol 2004; 151: U49-62.
Seckl JR, Meaney MJ. Glucocorticoid programming. Ann N Y Acad Sci 2004; 1032: 63-84.
Ravelli GP, Stein ZA, Susser MW. Obesity in young men after famine exposure in utero and early infancy. N Engl J Med 1976; 295: 253.
Ravelli ACJ, van der Meulen JHP, Michels RPI, et al. Glucose tolerance in adults after prenatal exposure to famine. Lancet 1998; 351: 173-7.
Roseboom TJ, van der Meulen JH, van Montfrans GA, Ravelli ACJ, Osmond C, Barker DJP, Bleker OP. Maternal nutrition during gestation and blood pressure in later life. J Hypertens 2001a; 19: 29-34.
Roseboom TJ, van der Meulen JH, Ravelli AC, Osmond C, Barker DJ, Bleker OP. Effects of prenatal exposure to the Dutch famine on adult disease in later life: an overview. Twin Res 2001b; 4: 293-8.
Jameson S. Zinc status in pregnancy: the effect of zinc therapy on perinatal mortality, prematurity and placental ablation. Ann N Y Acad Sci 1993; 678: 178-92.
Ladipo O. Nutrition in pregnancy: mineral and vitamin supplements. Am J Clin Nutr 2000; 72(Suppl. 1): 280S-290S.
Ramakrishnan U, Manjrekar R, Rivera J, Gonzalez-Cossio T, Martorell R. Micronutrients and pregnancy outcome: a review of the literature. Nutr Res 1999; 19: 103-59.
Thompson C, Syddall H, Rodin I, Osmond C, Barker DJP. Birth weight and the risk of depressive disorder in later life. Br J Psychiatry 2001; 179: 450-5.
Phillips DIW, Handelsman DJ, Eriksson JG, Forsén T, Osmond C, Barker DJP. Prenatal growth and subsequent marital status: longitudinal study. Br Med J 2001; 322: 771.
Neugenhauer R, Hoek HW, Susser E. Prenatal exposure to wartime famine and development of antisocial personality disorder in early adulthood. JAMA 1999; 281: 455-62.
Atlschuler EL. Schizophrenia and the Chinese famine of 1959-1961. JAMA 2005; 294: 2968.
Urizar GG, Milazzo M, Huynh-Nhu L, Delucchi K, Sotelo R, Muñoz RF. Impact of stress reduction instructions on stress and cortisol levels during pregnancy. Biol Psychiatry 2004; 67: 275-82.
Hodnett ED, Fredericks S. Support during pregnancy for women at increased risk of low birhtweight babies. Cochrane Database Systems Systematic Reviews 2000. No. 2. CD 000198.
Field T. Massage therapy effects. Am Psychol 1998; 53: 1270-81.
Ladipo O. Nutrition in pregnancy: mineral and vitamin supplements. Am J Clinical Nutrition 2000; 72(Suppl): 280S-90S.