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Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán

2007, Número 1

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Rev Invest Clin 2007; 59 (1)


Asociación entre polimorfismo de andrógenos y receptores de vitamina D con riesgo de cáncer prostático en una población mexicana

Patino-Garcia B, Arroyo C, Rangel-Villalobos H, Soto-Vega E, Velarde-Felix JS, Gabilondo F, Sandoval-Ramirez L, Figuera LE

Idioma: Español
Referencias bibliográficas: 37
Paginas: 25-31
Archivo PDF: 0. Kb.


RESUMEN

Introducción.El cancer de próstata (PCa)es un problema de salud mundial, tanto por su elevada incidenciacomo mortalidad.Su etiología es compleja e incluye factores de riesgo reconocidos como la edad, estado hormonal,origen étnico y antecedentes familiares de PCa.El fondo genético es un factor de riesgo y existen reportes controversiales de la asociación de PCa y polimorfismos en los genes como son los receptores de vitamina D(VDR)y el de andrógenos (AR).ObjetivosEvaluar las repeticiones de tripletes de CAG en el primer exon del AR y polimorfismos en el sitio de restricción Taq1 en el VDR en mexicanos con PCa.Material y métodosSe incluyeron 68 mexicanos con diagnóstico histopatológicos de PCa y 48 mexicanos con niveles normales de antígeno prostatico.ResultadosLa distribución alética y genotípica de los polimorfismos en el AR y VDR fueron consistentes con el equilibrio de Hardy_Weinberg, y no mostraron diferencias significativas entre los casos y controles (p›0.05).Sin embargo, el número de repeticiones de CAG en el AR fueron estadísticamente diferentes en pacientes jovenes.Conclusiones Nuestros resultados sugieren una asociacion entre los polimorfismos de los genes del VRD y AR y el patrón histólogico y la edad al diagnostico en pacientes mexicanos.Sin embargo, es necesario confirmar estos resultados en un estudio con mayor número de pacientes.


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