medigraphic.com
A partir del año 2010, la Revista Oficial del INER cambió a NCT (Neumología y Cirugía de Tórax)

 Ver actualización

2005, Número 1

<< Anterior Siguiente >>

Rev Inst Nal Enf Resp Mex 2005; 18 (1)


Ácido retinoico y función pulmonar

Parra-Hernández E, Nava-Reyes H, Zamudio-Cortés P

Idioma: Español
Referencias bibliográficas: 77
Paginas: 59-69
Archivo PDF: 112.33 Kb.


RESUMEN

El ácido retinoico (AR) es el principal metabolito de la vitamina A y es esencial, tanto en el desarrollo embrionario como en mantener el crecimiento en el organismo adulto. Asimismo, el AR es importante en periodos durante los cuales hay una proliferación celular acelerada, como ocurre en el desarrollo pulmonar. En el pulmón de los mamíferos el AR induce la formación y septación alveolar durante el desarrollo y periodo posnatal, pero este evento no sucede en el pulmón adulto. Sin embargo, hay evidencia que señala que el AR induce una regeneración alveolar completa cuando los alveolos han sido destruidos por tratamientos nocivos. En este artículo revisamos algunos de los efectos que tiene el AR en el desarrollo y regeneración pulmonar, así como su importancia terapéutica en enfermedades pulmonares.


REFERENCIAS (EN ESTE ARTÍCULO)

  1. Devlin TM. Textbook of biochemistry with clinical correlations. 5th rev ed. New York: Wiley-Liss; 2001.

  2. Burtis CA, Ashwood ER. Tietz fundamentals of clinical chemistry. 5th rev ed. Philadelphia: Saunders; 2001.

  3. Soprano DR, Soprano KJ. Retinoids as teratogens. Annu Rev Nutr 1995;15:111-132.

  4. McCollum EV, Davis M. The necessity of certain lipins in the diet during growth. J Biol Chem 1913;15: 167-175.

  5. Osborne TB, Mendel LB, Ferry EL, Wakeman AJ. The relation of growth to the chemical constituents of the diet. J Biol Chem 1913;15:311-326.

  6. Hughes JS, Lienhardt HF, Aubel CE. Nerve degeneration resulting from avitaminosis A. J Nutr 1929;2: 183-186.

  7. Hart EB, Miller WS, McCollum EV. Further studies on the nutritive deficiencies of wheat and grain mixtures and the pathological conditions produced in swine by their use. J Biol Chem 1916;25:239-259.

  8. Steenbock H, Coward KH. Fat-soluble vitamins. XXVII. The quantitative determination of vitamin A. J Biol Chem 1927;72:765-779.

  9. Isler O, Zeller P. Total syntheses of carotenoids. Vitam Horm 1957;15:31-71.

  10. Boehm MF, Zhang L, Zhi L, et al. Design and synthesis of potent retinoid X receptor selective ligands that induce apoptosis in leukemia cells. J Med Chem 1995;38:3146-3155.

  11. De Luca LM. Retinoids and their receptors in differentiation, embryogenesis, and neoplasia. FASEB J 1991;5:2924-2933.

  12. Yang Y, Vacchio MS, Ashwell JD. 9-cis-retinoic acid inhibits activation-driven T-cell apoptosis: implications for retinoid X receptor involvement in thymocyte development. Proc Natl Acad Sci USA 1993;90:6170-6174.

  13. Deigner HP, Kinscherf R. Modulating apoptosis: current applications and prospects for future drug development. Curr Med Chem 1999;6:399-414.

  14. Delia D, Aiello A, Lombardi L, et al. N-(4-hydroxyphenyl) retinamide induces apoptosis of malignant hemopoietic cell lines including those unresponsive to retinoic acid. Cancer Res 1993;53:6036-6041.

  15. Wolf G. Multiple functions of vitamin A. Physiol Rev 1984;64:873-937.

  16. Hale F. Pigs born without eye balls. J Hered 1933;24:105-106.

  17. Wilson JG, Roth CB, Warkany J. An analysis of the syndrome of malformations induced by maternal vitamin A deficiency. Effects of restoration of vitamin A at various times during gestation. Am J Anat 1953;92:189-217.

  18. Thompson JN, Howell JM, Pitt GA, McLaughlin CI. The biological activity of retinoic acid in the domestic fowl and the effects of vitamin A deficiency on the chick embryo. Br J Nutr 1969;23:471-490.

  19. Zile MH. Vitamin A and embryonic development: an overview. J Nutr 1998;128(2 Suppl):455-458.

  20. Cohlan SQ. Excessive intake of vitamin A as a cause of congenital anomalies in the rat. Science 1953;117: 535-536.

  21. Cohlan SQ. Congenital anomalies in the rat produced by excessive intake of vitamin A during pregnancy. Pediatrics 1954;13:556-567.

  22. Lammer EJ, Chen DT, Hoar RM, et al. Retinoic acid embryopathy. N Engl J Med 1985;313:837-841.

  23. Fisher GJ, Voorhees JJ. Molecular mechanisms of retinoid actions in skin. FASEB J 1996;10:1002-1013.

  24. Windhorst DB. The use of isotretinoin in disorders of keratinization. J Am Acad Dermatol 1982;6:708-709.

  25. Camisa C. Treatment of severe psoriasis with systemic drugs. Dermatol Nurs 1995;7:107-118.

  26. Hill DL, Grubbs CJ. Retinoids and cancer prevention. Annu Rev Nutr 1992;12:161-181.

  27. Warrell RP Jr, de The H, Wang ZY, Degos L. Acute promyelocytic leukemia. N Engl J Med 1993;329: 177-189.

  28. Massaro GD, Massaro D. Postnatal treatment with retinoic acid increases the number of pulmonary alveoli in rats. Am J Physiol 1996;270(2 Pt 1):305-310.

  29. Dancis J, Levitz M, Katz J, et al. Transfer and metabolism of retinol by the perfused human placenta. Pediatr Res 1992;32:195-199.

  30. McCaffery P, Drager UC. Retinoic acid synthesizing enzymes in the embryonic and adult vertebrate. Adv Exp Med Biol 1995;372:173-183.

  31. Ross AC, Zolfaghari R, Weisz J. Vitamin A: recent advances in the biotransformation, transport, and metabolism of retinoids. Curr Opin Gastroenterol 2001;17: 184-192.

  32. Napoli JL. Retinoic acid synthesis from beta-carotene in vitro. Methods Enzymol 1993;214:193-202.

  33. Napoli JL. Retinoic acid biosynthesis and metabolism. FASEB J 1996;10:993-1001.

  34. Frolik CA, Roberts AB, Tavela TE, Roller PP, Newton DL, Sporn MB. Isolation and identification of 4-hydroxy- and 4-oxoretinoic acid. In vitro metabolites of all-trans-retinoic acid in hamster trachea and liver. Biochemistry 1979;18:2092-2097.

  35. Duester G. Involvement of alcohol dehydrogenase, short-chain dehydrogenase/reductase, aldehyde dehydrogenase, and cytochrome P450 in the control of retinoid signaling by activation of retinoic acid synthesis. Biochemistry 1996;35:12221-12227.

  36. White JA, Guo YD, Baetz K, et al. Identification of the retinoic acid-inducible all-trans-retinoic acid 4-hydroxylase. J Biol Chem 1996;271:29922-29927.

  37. Sonneveld E, van den Brink CE, Tertoolen LG, van der Burg B, van der Saag PT. Retinoic acid hydroxy-lase (CYP26) is a key enzyme in neuronal differentiation of embryonal carcinoma cells. Dev Biol 1999;213: 390-404.

  38. Urbach J, Rando RR. Isomerization of all-trans-retinoic acid to 9-cis-retinoic acid. Biochem J 1994;299:459-465.

  39. Napoli JL. Biosynthesis and metabolism of retinoic acid: roles of CRBP and CRABP in retinoic acid homeostasis. J Nutr 1993;123:362-366.

  40. Chambon P. A decade of molecular biology of retinoic acid receptors. FASEB J 1996;10:940-954.

  41. Allenby G, Bocquel MT, Saunders M, et al. Retinoic acid receptors and retinoid X receptors: interactions with endogenous retinoic acids. Proc Natl Acad Sci USA 1993;90:30-34.

  42. Giguere V, Fawcett D, Luo J, Evans RM, Sucov HM. Genetic analysis of the retinoid signal. Ann N Y Acad Sci 1996;785:12-22.

  43. Chytil F. The lungs and vitamin A. Am J Physiol 1992;262(5 Pt 1):517-527.

  44. Chytil F. Retinoids in lung development. FASEB J 1996;10:986-992.

  45. Zachman RD. Role of vitamin A in lung development. J Nutr 1995;125:(6 Suppl):1634-1638.

  46. Bostrom H, Willetts K, Pekny M, et al. PDGF-A signaling is a critical event in lung alveolar myofibroblast development and alveogenesis. Cell 1996;85:863-873.

  47. Schuger L, Varani J, Mitra R Jr. Gilbride K. Retinoic acid stimulates mouse lung development by a mechanism involving epithelial-mesenchymal interaction and regulation of epidermal growth factor receptors. Dev Biol 1993;159:462-473.

  48. Harrison EH. Enzymes catalyzing the hydrolysis of retinyl esters. Biochim Biophys Acta 1993;1170:99-108.

  49. Maksvytis HJ, Niles RM, Simanovsky L, et al. In vitro characteristics of the lipid-filled interstitial cell associated with postnatal lung growth: evidence for fibroblast heterogeneity. J Cell Physiol 1984;118:113-123.

  50. Okabe T, Yorifuji H, Yamada E, Takaku F. Isolation and characterization of vitamin-A-storing lung cells. Exp Cell Res 1984;154:125-135.

  51. Grummer MA, Thet LA, Zachman RD. Expression of retinoic acid receptor genes in fetal and newborn rat lung. Pediatr Pulmonol 1994;17:234-238.

  52. McGowan SE, Harvey CS, Jackson SK. Retinoids, retinoic acid receptors, and cytoplasmic retinoid binding proteins in perinatal rat lung fibroblasts. Am J Physiol 1995;269:L463-472.

  53. Massaro GD, Massaro D, Chambon P. Retinoic acid receptor-alpha regulates pulmonary alveolus formation in mice after, but not during, perinatal period. Am J Physiol Lung Cell Mol Physiol 2003;284:L431-L433.

  54. Massaro GD, Massaro D, Chan WY, et al. Retinoic acid receptor-beta: an endogenous inhibitor of the perinatal formation of pulmonary alveoli. Physiol Genomics 2000;4:51-57.

  55. Lohnes D, Kastner P, Dierich A, Mark M, LeMeur M, Chambon P. Function of retinoic acid receptor gamma in the mouse. Cell 1993;73:643-658.

  56. Kastner P, Grondona JM, Mark M, et al. Genetic analysis of RXR alpha developmental function: convergence of RXR and RAR signaling pathways in heart and eye morphogenesis. Cell 1994;78:987-1003.

  57. Dolle P, Fraulob V, Kastner P, Chambon P. Developmental expression of murine retinoid X receptor (RXR) genes. Mech Dev 1994;45:91-104.

  58. McGowan S, Jackson SK, Jenkins-Moore M, Dai HH, Chambon P, Snyder JM. Mice bearing deletions of retinoic acid receptors demonstrate reduced lung elastin and alveolar numbers. Am J Respir Cell Mol Biol 2000;23:162-167.

  59. Hind M, Corcoran J, Maden M. Temporal/spatial expression of retinoid binding proteins and RAR isoforms in the postnatal lung. Am J Physiol Lung Cell Mol Physiol 2002;282:L468-L476.

  60. Hind M, Maden M. Retinoic acid induces alveolar regeneration in the adult mouse lung. Eur Respir J 2004;23:20-27.

  61. Hind M, Corcoran J, Maden M. Alveolar proliferation, retinoid synthesizing enzymes, and endogenous retinoids in the postnatal mouse lung. Different roles for Aldh-1 and Raldh-2. Am J Respir Cell Mol Biol 2002;26:67-73.

  62. Massaro GD, Massaro D. Retinoic acid treatment abrogates elastase-induced pulmonary emphysema in rats. Nat Med 1997;3:675-677.

  63. Karlinsky JB, Snider GL. Animal models of emphysema. Am Rev Respir Dis 1978;117:1109-1133.

  64. Janoff A. Elastases and emphysema. Current assessment of the protease-antiprotease hypothesis. Am Rev Respir Dis 1985;132:417-433.

  65. Furuno T, Mitsuyama T, Hidaka K, Tanaka T, Hara N. The role of neutrophil elastase in human pulmonary artery endothelial cell injury. Int Arch Allergy Immunol 1997;112:262-269.

  66. Dane DM, Yan X, Tamhane RM, et al. Retinoic acid-induced alveolar cellular growth does not improve function after right pneumonectomy. J Appl Physiol 2004;96:1090-1096.

  67. Li T, Molteni A, Latkovich P, Castellani W, Baybutt RC. Vitamin A depletion induced by cigarette smoke is associated with the development of emphysema in rats. J Nutr 2003;133: 2629-2634.

  68. Baybutt RC, Hu L, Molteni A. Vitamin A deficiency injures lung and liver parenchyma and impairs function of rat type II pneumocytes. J Nutr 2000;130: 1159-1165.

  69. Tepper J, Pfeiffer J, Aldrich M, et al. Can retinoic acid ameliorate the physiologic and morphologic effects of elastase instillation in the rat? Chest 2000;117(Suppl 1):242-244.

  70. Fujita M, Ye Q, Ouchi H, et al. Retinoic acid fails to reverse emphysema in adult mouse models. Thorax 2004;59:224-230.

  71. Meshi B, Vitalis TZ, Ionescu D, et al. Emphysematous lung destruction by cigarette smoke. The effects of latent adenoviral infection on the lung inflammatory response. Am J Respir Cell Mol Biol 2002;26:52-57.

  72. March TH, Cossey PY, Esparza DC, Dix KJ, McDonald JD, Bowen LE. Inhalation administration of all-trans-retinoic acid for treatment of elastase-induced pulmonary emphysema in Fischer 344 rats. Exp Lung Res 2004;30:383-404.

  73. Lucey EC, Goldstein RH, Breuer R, Rexer BN, Ong DE, Snider GL. Retinoic acid does not affect alveolar septation in adult FVB mice with elastase-induced emphysema. Respiration 2003;70:200-205.

  74. Nishi Y, Boswell V, Ansari T, Piprawala F, Satchi S, Page CP. Elastase-induced changes in lung function: relationship to morphometry and effect of drugs. Pulm Pharmacol Ther 2003;16:221-229.

  75. Mao JT, Goldin JG, Dermand J, et al. A pilot study of all-trans-retinoic acid for the treatment of human emphysema. Am J Respir Crit Care Med 2002;165: 718-723.

  76. Thom TJ. International comparisons in COPD mortality. Am Rev Respir Dis 1989;140(3 Pt 2):27-34.

  77. Murray CJL, Lopez AD. Evidence-Based Health Policy - Lessons from the Global Burden of Disease Study. Science 1996;274:740-743.




2020     |     www.medigraphic.com