Gutiérrez-Castro M, De León-Bojorge B, Cuesta-Mejías T, Baquera-Heredia J, Padilla-Rodríguez A, Ortiz-Hidalgo C

Idioma: Español
Referencias bibliográficas: 30
Paginas: 441-449
Archivo PDF: 115.55 Kb.

RESUMEN

La enfermedad de Kikuchi-Fujimoto o linfadenitis histiocítica necrosante (LHN) es una entidad poco frecuente, inicialmente descrita en población japonesa. Sin embargo, actualmente se ha descrito alrededor de todo el mundo. Es más frecuente en mujeres jóvenes y su localización habitual es en ganglios linfáticos cervicales. Presentamos estudio clinicopatológico de 14 casos de LHN en pacientes mexicanos, y los comparamos con linfadenitis necrosantes secundarias a linfomas B y T, tuberculosis, virus de Epstein Barr y necrosis inespecífica. Encontramos mayor expresión de los anticuerpos CD68, MPO, CD123 y antiqueratina OSCAR en los casos de LHN comparados con la expresión baja o nula de los mismos anticuerpos en las necrosis ganglionares del grupo comparativo.

REFERENCIAS (EN ESTE ARTÍCULO)

1. Kikuchi M. Lymphadenitis showing focal reticulum cell hyperplasia with nuclear debris and phagocytes: A clinic-pathological study. Nippon Ketsueki Gakkai Zasshi 1972; 35: 379-80.

2. Fujimoto Y, Kozima Y, Yamaguchi K. Cervical subacute necrotizing lymphadenitis. A new clinic-pathologic entity. Naika 1972; 20: 920-7.

3. Pileri S, Kikuchi M, Helbron D, Lennert K. Histiocytic necrotizing lymphadenitis without granulocytic infiltration. Virchows Arch a Pathol Anat Histol 1982; 395: 257-71.

4. Turner RR, Martin J, Dorfman RF. Necrotizing lymphadenitis: a study of 30 cases. Am J Surg Pathol 1983; 7: 115-23.

5. Rivano MT, Falini B, Stein H, Canino S, Ciani C, Gerdes J, Ribacchi R, Gobbi M, Pileri S. Histiocytic necrotizing lymphadenitis without granulocytic infiltration (Kikuchi’s lymphadenitis). Morphological and immunohistochemical study of eight cases. Histopathology 1987; 11: 1013-27.

6. Dorfman RF, Berry GJ. Kikuchi’s histiocytic necrotizing lymphadenitis: an analysis of 108 cases with emphasis on differential diagnosis. Semin Diagn Pathol 1988; 5: 329-45.

7. Chamulak GA, Brynes RK, Nathwani BN. Kikuchi-Fujimoto disease mimicking malignant lymphoma. Am J Surg Pathol 1990; 14: 514-23.

8. Tsang WY, Chan JK, Ng CS. Kikuchi’s lymphadenitis. A morphologic analysis of 75 cases with special reference to unusual features. Am J Surg Pathol 1994;18:219-31.

9. Kuo TT. Kikuchi’s disease (histiocytic necrotizing lymphadenitis). A clinicopathologic study of 79 cases with an analysis of histologic subtypes, immunohistology, and DNA ploidy. Am J Surg Pathol 1995; 19: 798-809.

10. Chuang Ch, Yan D, Chiu Ch. Clinical and laboratory manifestations of Kikuchi’s disease in children and differences between patients with and without prolonged fever. Pediatr Infect Dis J 2005; 24: 551-4.

11. Blewitt RW, Kumar SN, Abraham JS. Recurrence of Kikuchi’s lymphadenitis after 12 years. J Clin Pathol 2000; 53: 157-8.

12. Spies J, Foucar K. The histopathology of cutaneous lesions of Kikuchi’s disease. Am J Surg Pathol 1999; 23: 1040-7.

13. Tumiati B, Bellelli A, Portioli I, Prandi S. Kikuchi’s disease in systemic lupus erythematosus: an independent or dependent event? Clin Rheumatol 1991; 10: 90-3.

14. Litwin MD, Kirkham B, Henderson DR, Milazzo SC. Histiocytic necrotising lymphadenitis in systemic lupus erythematosus. Ann Rheum Dis 1992; 51: 805-7.

15. el-Ramahi KM, Karrar A, Ali MA. Kikuchi disease and its association with systemic lupus erythematosus. Lupus 1994; 3: 409-11.

16. Eisner MD, Amory J, Mullaney B, Tierney L, Browner WS. Necrotizing lymphadenitis associated with systemic lupus erythematosus. Semin Arthritis Rheum 1996; 26: 477-82.

17. Chen YH, Lan JL. Kikuchi disease in systemic lupus erythematosus: clinical features and literature review. J Microbiol Immunol Infect 1998; 31: 187-92.

18. Yen A, Fearneyhough P, Raimer SS, Hudnall SD. EBV-associated Kikuchis, histiocytic necrotizing lymphadenitis with cutaneous manifestations. J Am Acad Dermatol 1997; 36: 342-6.

19. Rodríguez MJ, Martin MV, Báez JM, Gil JL. Kikuchi-Fujimoto necrotizing lymphadenitis associated with brucellosis. Sangre (Barc). 1992; 37: 201-4

20. Kikuchi M, Yoshizumi T, Nakamura H. Necrotizing lymphadenitis: possible acute toxoplasmic infection. Virchows Arch A Pathol Anat Histol 1977; 376: 247-53.

21. Rodríguez JN, Aguayo DM, Elizalde J, Martino ML, Moreno MV, Lara C, Prados D. Kikuchi-Fujimoto disease associated with acute infection by herpes virus 6. Sangre (Barc) 1996; 41: 387-90.

22. Bataille V, Harland CC, Behrens J, Cook MG, Holden CA. Kikuchi disease (histiocytic necrotizing lymphadenitis) in association with HTLV1. Br J Dermatol 1997; 136: 610-12.

23. Huh J, Kang GH, Gong G, Kim SS, Ro JY, Kim CW. Kaposi’s sarcoma-associated herpes virus in Kikuchi’s disease. Hum Pathol 1998; 29:1091-6.

24. Meyer O, Kahn MF, Grossin M, Ribard P, Belmatoug N, Morinet F, Fournet JC. Parvovirus B19 infection can induce histiocytic necrotizing lymphadenitis (Kikuchi’s disease) associated with systemic lupus erythematosus. Lupus 1991; 1: 37-41.

25. Yufu Y, Matsumoto M, Miyamura T, Nishimura J, Nawata H, Ohshima K. Parvovirus B19-associated haemophagocytic syndrome with lymphadenopathy resembling histiocytic necrotizing lymphadenitis (Kikuchi’s disease). Br J Haematol 1997; 96: 868-71.

26. Onciu M, Medeiros LJ. Kikuchi-Fujimoto lymphadenitis. Adv Anat Pathol 2003; 10: 204-11.

27. Pileri S, Facchetti F, Ascani S, Sabattini E, Poggi S, Piccioli M, Rondelli D, Vergoni F, Zinzani PL, Piccaluga PP, Falini B, Isaacson PG. Myeloperoxidase expression by histiocytes in Kikuchi’s and Kikuchi-Like lymphadenopathy. Am J Pathol 2001; 159: 915-24.

28. Facchetti F, De Wolf-Peeters C, Van Den Oord J. Plasmacytoid monocytes (so-called plasmacytoid T-cells) in Kikuchi’s lymphadenitis. Am J Clin Pathol 1989; 92: 42-50.

29. Ortiz-Hidalgo C, Torres J. Citokeratin-positive interstitial reticulum cells in Kikuchi-Fujimoto disease. App Immunohistochem Mol Morphol 2002; 10: 194-5.

30. Gown AM, Yaziji H, Barry TS, Hwang HC. OCSAR, a novel broad anti-cytokeratin monoclonal antibody optimized for diagnostic immunohistochemistry. Mod Pathol 2003; 16: 322.