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Colegio de Medicina Interna de México.

2007, Número 2

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Med Int Mex 2007; 23 (2)


Enfermedad ósea en mieloma múltiple: biología y tratamiento

Jiménez ZVH, Martínez LE

Idioma: Español
Referencias bibliográficas: 42
Paginas: 126-132
Archivo PDF: 153.83 Kb.


RESUMEN

La enfermedad ósea es un hallazgo importante del mieloma múltiple. La destrucción ósea mediada por mieloma es resultado del incremento de la actividad de los osteoclastos que no se acompaña de aumento comparable al de la función osteoblástica. Los estudios recientes revelan que nuevas moléculas, como el activador del receptor del factor nuclear kappa B (RANK), su ligando (RANK-L), osteoprotegerina (OPG) y la proteína inflamatoria del macrófago-1 participan en la activación y diferenciación osteoclástica, mientras que proteínas como la DKK1 inhiben la formación osteoblástica. En la actualidad, los bifosfonatos tienen un papel importante en el tratamiento de la enfermedad ósea en mieloma. El clodronato, pamidronato y el ácido zoledrónico son los bifosfonatos más eficaces en pacientes sintomáticos con mieloma.


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