Zárate A, Saucedo R, Basurto L, Martínez C

Idioma: Español
Referencias bibliográficas: 44
Paginas: 286-292
Archivo PDF: 319.15 Kb.

RESUMEN

La enfermedad cardiovascular es la principal causa de muerte de mujeres. El riesgo de padecerla se incrementa después de la menopausia debido a los cambios metabólicos y hormonales que se producen en esta etapa. La disminución de la función ovárica se vincula con incremento de citocinas proinflamatorias. La inflamación crónica es un factor principal en la aterosclerosis y la aterotrombosis. Se han propuesto diversos marcadores de inflamación como un método para evaluar el riesgo de enfermedad cardiovascular en mujeres adultas mayores supuestamente sanas. Al parecer, los estrógenos endógenos tienen propiedades cardioprotectoras, incluso en algunos estudios observacionales se sugirió que la terapia hormonal reduce la probabilidad de enfermedad cardiovascular en mujeres posmenopáusicas sanas; sin embargo, pruebas clínicas recientes no han demostrado ese beneficio. Entre los mecanismos involucrados en los efectos de la terapia hormonal en la enfermedad cardiovascular está la inflamación.

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