Díaz de LPMA, Briones GJC

Idioma: Español
Referencias bibliográficas: 30
Paginas: 122-123
Archivo PDF: 43.08 Kb.

FRAGMENTO

La investigación es clave en la generación, aplicación y renovación de herramientas diagnósticas, preventivas y de tratamiento oportuno para nuestros pacientes. Un conflicto paradójico es que la investigación en estos campos se genera en países desarrollados que distan mucho de tener los problemas de salud de nuestro tercer mundo como también la vivencia de una realidad económica y de desigualdades en salud muy diferentes a las que tenemos a diario. Esta es la razón de la necesidad que tenemos de generar una investigación en un nivel práctico secundario no orientada tanto a las ciencias básicas sino más tendientes a los campos de la epidemiología clínica, la estadística, las ciencias sociales, la economía en salud y la satisfacción del usuario.

REFERENCIAS (EN ESTE ARTÍCULO)

1. Angus DC, Barnato AE, Linde-Zwrible WT, Weissfeld LA, Watson S, Rickert T, Rubenfeld G on behalf of the Robert Wood Johnson Foundation ICU end of life Peer Group. Use of intensive care at the end of life in the United States. Crit Care Med 2004;32:638-643.

2. Kersten A, Milbrandt EB, Rahim MT, Watson RS, Clermont G, Angus DC, Linde-Zwirble WT. How big is critical care in the US? Crit Care Med 2003;31:A8.

3. White J. Uses and abuses of long term medicare cost estimates. Health Aff (Millwood) 1999;18:63-79.

4. Angus DC, Kelley MA, Schmitz RJ, White A, Popovich J Jr, for the Committee on Manpower for Pulmonary and Critical Care Societies (COMPACCS). Current and projected workforce requirements for care of the critically ill and patients with pulmonary disease: can we meet the requirements of an aging population? JAMA 2000;284:2762-2770.

5. Brochard L. Searching for evidence: don’t forget the foundations. Intensive Care Med 2003;29:2109-2111.

6. Luce JM. Is the concept of informed consent applicable to clinical research involving critically ill subjects? Crit Care Med 2003;31:S153-S160.

7. Truog RD, Robinson W, Randolph A, Morris A. Is informed consent always necessary for randomized, controlled trials? N Engl J Med 1999;340:804-807.

8. National Commission for the Protection of Human Subjects of Biomedical and Behavioral Research. The Belmont Report: Ethical Principles and Guidelines for the Protection of Human Subjects in Research. Washington, DC: US Government Printing Office, 1979.

9. Emanuel EJ, Wendler D, Grady C. What makes clinical research ethical? JAMA 2000;283:2701-2711.

10. Nuremberg Code. In: Trials of War Criminals Before the Nuremberg Military Tribunals Under Control Council Law. No. 10. Vol 2, Nuremberg, October 1946 – April 1949. Washington, DC: US Government Printing Office, 1949.

11. World Medical Association. Declaration of Helsinki: Ethical Principles for Medical Research Involving Human Subjects, Revised. Ferney-Voltaire, France: World Medical Association, 2000.

12. Freedman B. Equipoise and the ethics of clinical research. N Engl J Med 1987;317:141-145.

13. Institute of Medicine. Responsible Research: a Systems Approach to Protecting Research Participants. Washington, DC: National Academies Press, 2003.

14. Agrawal M, Emanuel EJ. Ethics of phase 1 oncology studies; reexamining the arguments and data. JAMA 2003;290:1075-1082.

15. Appelbaum PS, Roth LH, Lidz CW, Benson P, Winslade W. False hopes and best data: consent to research and the therapeutic misconception. Hastings Cent Rep 1987;17:20-24.

16. Miller FG, Rosenstein DL. The therapeutic orientation to clinical trials. N Engl J Med 2003;348:1383-1386.

17. Grunberg SM, Cefalu WT. The integral role of clinical research in clinical care. N Engl J Med 2003;348:1386-1388.

18. Halpern SD, Karlawish JHT, Berlin JA. The continuing unethical conduct of underpowered clinical trials. JAMA 2002;288:358-362.

19. Steinbrook R. How best to ventilate? Trial design and patient safety in studies of the acute respiratory distress syndrome. N Engl J Med 2003;348:1393-1401.

20. Steinbrook R. Trial design and patient safety – the debate continues. N Engl J Med 2003;349:629-630.

21. Miller FG, Silverman HJ. The ethical relevance of the standard of care in the design of clinical trials. Am J Respir Crit Care Med 2004;169:562-564.

22. Silverman HJ, Miller FG. Control group selection in critical care randomized controlled trials evaluating interventional strategies: an ethical assessment. Crit Care Med 2004;32:852-857.

23. Krishnan JA, Moore D, Robeson C, Rand CS, Fessler HE. A prospective, controlled trial of s protocol-based strategy to discontinue mechanical ventilation. Am J Respir Crit Care Med 2004;169:673-678.

24. Sandham JD, Hull RD, Brant RF, Knox L, Pineo GF, Doig CJ, Laporta DP, Viner S, Passerini L, Devitt H et al, for the Canadian Critical Care Trials Group. A randomized, controlled trial of the use of pulmonary artery catheters in high-risk surgical patients. N Engl J Med 2003;348:5-14.

25. Richard-PAC, Richard C, Warszawski J, Anguel N, Deye N, Combes A, Barnoud D, Boulain T, Lefort Y, Fartoukh M et al, for the French Pulmonary Artery Catheter Study Group. Early use of the pulmonary artery catheter and outcomes in patients with shock and acute respiratory distress syndrome: a randomized controlled trial. JAMA 2003;290:2713-2720.

26. Department of Health and Human Services. Common Rule (45 CFR 46). Federal policy for the protection of human subjects; notices and rules. 1991: 28003-28032.

27. Slutsky AS, Lavery JV. Data safety and monitoring boards. N Engl J Med 2004;350:1143-1147.

28. Ellenberg SS, Fleming TR, DeMets DL. Data monitoring committees in clinical trials: a practical perspective. Chichester, England: John Wiley; 2002.

29. Freeman BD, Danner RL, Banks SM, Natanson C. Safeguarding patients in clinical trials with high mortality rates. Am J Respir Crit Care Med 2001;164:190-192.

30. Steinbrook R. Protecting research subjects: the crisis at Johns Hopkins. N Engl J Med 2002;346:716-720.