2008, Número 1
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Salud Mental 2008; 31 (1)
Vías de neuroinmunomodulación. Segunda parte
Hernández ME, Becerril LE, Alvarez L, Pavón-Romero L
Idioma: Español
Referencias bibliográficas: 115
Paginas: 29-36
Archivo PDF: 72.60 Kb.
FRAGMENTO
VÍA COLINÉRGICA ANTI-INFLAMATORIA
Los componentes simpático y parasimpático del sistema nervioso autónomo raramente operan de forma aislada; la respuesta autónoma representa la interconexión de ambas partes. La interacción entre el sistema nervioso autónomo y la respuesta inmunológica fue sugerida desde hace más de 20 años, cuando se detectó que la estimulación colinérgica muscarínica generaba un incremento en la población de los linfocitos T citotóxicos (Strom y cols., 1972). A pesar de esta observación la acción inmunomodulatoria de la función de las eferencias vagales y parasimpáticas aún no se comprende del todo (Antonica y cols., 1994; Hori y cols., 1995; Niijima y cols., 1995).
REFERENCIAS (EN ESTE ARTÍCULO)
Adcock IM, Ito K. Molecular mechanisms of corticosteroid actions. Monaldi Arch Chest Dis 2006;55:256-266.
Ader R, Felten D, Cohen N Psychoneuroimmunology. Academic Press (eds) Third Edition. USA. 2001.
Antonica A, Magni F, Mearini L, Paolocci N. Vagal control of lymphocyte release from rat thymus. J Auton Nerv Syst 1994;48:187-197.
Banks WA, Kastin AJ, Broadwell RD. Passage of cytokines across the blood-brain barrier. Neuroimmunomodulation 1995;2:241-248.
Baumann H, Gauldie J. The acute phase response. Immunol Today 1994;15:74-80.
BEHL C. Oestrogen as a neuroprotective hormone. Nat Rev Neurosci 2002;3:433-442.
Bernik TR, Friedman SG, Ochani M, et al. Pharmacological stimulation of the cholinergic antiinflammatory pathway. J Exp Med 2002;195:781-788.
Berthoud HR, Neuhuber WL. Functional and chemical anatomy of the afferent vagal system. Auton Neurosci 2000;85:1-17.
Bianchi M, Bloom O, Raabe T, et al. Suppression of proinflammatory cytokines in monocytes by a tetravalent guanylhydrazone. J Exp Med 1996;183:927-936.
Blalock JE. Harnessing a neural-immune circuit to control inflammation and shock. J Exp Med 2002;195:F25-F28.
Blondeau C, Clerc N, Baude A. Neurokinin-1 and neurokinin-3 receptors are expressed in vagal efferent neurons that innervate different parts of the gastro-intestinal tract. Neuroscience 2002;110:339-349.
Borovikova LV, Ivanova S, Nardi D, et al. Role of vagus nerve signaling in CNI-1493-mediated suppression of acute inflammation. Auton Neurosci 2000a;85:141-147.
Borovikova LV, Ivanova S, Zhang M, et al. Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin. Nature 2000b;405:458-462.
Browning KN, Travagli RA. Mechanism of action of baclofen in rat dorsal motor nucleus of the vagus. Am J Physiol Gastrointest Liver Physiol 2001;280:G1106-G1113.
Buller KM. Role of circumventricular organs in pro-inflammatory cytokine- induced activation of the hypothalamic-pituitary-adrenal axis. Clin Exp Pharmacol Physiol 2001;28:581-589.
Buller KM. Neuroimmune stress responses: reciprocal connections between the hypothalamus and the brainstem. Stress 2003;6:11-17.
Catania A, Airaghi L, Colombo G, Lipton JM. Alpha-melanocyte-stimulating hormone in normal human physiology and disease states. Trends Endocrinol Metab 2000;11:304-308.
Catania A, Suffredini AF, Lipton JM. Endotoxin causes release of alphamelanocyte- stimulating hormone in normal human subjects. Neuroimmunomodulation 1995;2:258-262.
Caulfield MP, Birdsall NJ. International Union of Pharmacology. XVII. Classification of muscarinic acetylcholine receptors. Pharmacol Rev 1998;50:279-290.
Chensue SW, Terebuh PD, Remick DG, et al. In vivo biologic and immunohistochemical analysis of interleukin-1 alpha, beta and tumor necrosis factor during experimental endotoxemia. Kinetics, Kupffer cell expression, and glucocorticoid effects. Am J Pathol 1991;138:395-402.
DA Silva JA, Colville-Nash P, Spector TD, et al. Inflammation-induced cartilage degradation in female rodents. Protective role of sex hormones. Arthritis Rheum 1993;36:1007-1013.
Deshpande R, Khalili H, Pergolizzi RG, et al. Estradiol down-regulates LPS-induced cytokine production and NFkB activation in murine macrophages. Am. J Reprod Immunol 1997;38:46-54.
EK M, Engblom D, Saha S, et al. Inflammatory response: pathway across the blood-brain barrier. Nature 2001;410:430-431.
Elenkov IJ, Wilder RL, Chrousos GP, et al. The sympathetic nerve—an integrative interface between two supersystems: the brain and the immune system. Pharmacol Rev 2000;52:595-638.
Elmquist JK, Scammell Te, Saper CB. Mechanisms of CNS response to systemic immune challenge: the febrile response. Trends Neurosci 1997;20:565-570.
Ferreira M, Ebert SN, Perry DC, et al. Evidence of a functional alpha7- neuronal nicotinic receptor subtype located on motoneurons of the dorsal motor nucleus of the vagus. J Pharmacol Exp Ther 2001;296:260-269.
Gaillard RC. Immuno-endocrine interactions at the hypothalamo-hypophyseal level. Ann Endocrinol 1995;56:561-566.
Gaykema RP, Dijkstra I, Tilders FJ. Subdiaphragmatic vagotomy suppresses endotoxin-induced activation of hypothalamic corticotropinreleasing hormone neurons and ACTH secretion. Endocrinology 1995;136:4717-4720.
George MS, Sackeim HA, Marangell LB, et al. Vagus nerve stimulation. A potential therapy for resistant depression? Psychiatr Clin North Am 2000a;23:757-783.
George MS, Sackeim HA, Rush AJ, et al. Vagus nerve stimulation: a new tool for brain research and therapy. Biol Psychiatry 2000b;47:287-295.
Ghosh S, May MJ, Kopp EB. NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses. Annu. Rev Immunol 1998;16:225-260.
Goehler LE, Gaykema RP, Hansen MK, et al. Vagal immune-to-brain communication: a visceral chemosensory pathway. Auton Neurosci 2000;85:49-59.
Goehler LE, Gaykema RP, Nguyen KT, et al. Interleukin-1beta in immune cells of the abdominal vagus nerve: a link between the immune and nervous systems? J Neurosci 1999;19:2799-2806.
Hallenbeck JM. The many faces of tumor necrosis factor in stroke. Nat Med 2002;8:1363-1368.
Handforth A, Degiorgio CM, Schachter SC, et al. Vagus nerve stimulation therapy for partial-onset seizures: a randomized active-control trial. Neurology 1998;51:48-55.
Hansen MK, Nguyen KT, Fleshner M, et al. Effects of vagotomy on serum endotoxin, cytokines, and corticosterone after intraperitoneal lipopolysaccharide. Am J Physiol Regul Integr Comp Physiol 2000;278:R331-R336.
Hasko G, Szabo C. Regulation of cytokine and chemokine production by transmitters and co-transmitters of the autonomic nervous system. Biochem Pharmacol 1998;56:1079-1087.
Hermann GE, Emch GS, Tovar CA, Rogers RC. c-Fos generation in the dorsal vagal complex after systemic endotoxin is not dependent on the vagus nerve. Am J Physiol Regul Integr Comp Physiol 2001;280:R289- R299.
Hiemke C, Stolp M, Reuss S, et al. Expression of alpha subunit genes of nicotinic acetylcholine receptors in human lymphocytes. Neurosci Lett 1996;214:171-174.
Honzikova N, Semrad B, Fiser B, Labrova R. Baroreflex sensitivity determined by spectral method and heart rate variability, and two-years mortality in patients after myocardial infarction. Physiol Res 2000;49:643-650.
Hoover DB, Hancock JC, Deporter TE. Effect of vagotomy on cholinergic parameters in nuclei of rat medulla oblongata. Brain Res Bull 1985;15:5-11.
Hopkins SJ, Rothwell NJ. Cytokines and the nervous system. I: Expression and recognition. Trends Neurosci 1995;18:83-88.
Hori T, Katafuchi T, Take S, et al. The autonomic nervous system as a communication channel between the brain and the immune system. Neuroimmunomodulation 1995;2:203-215.
Hornby PJ Receptors and transmission in the brain-gut axis. II. Excitatory amino acid receptors in the brain-gut axis. Am J Physiol Gastrointest Liver Physiol 2001;280:G1055-G1060.
Hyde TM, Gibbs M, Peroutka SJ. Distribution of muscarinic cholinergic receptors in the dorsal vagal complex and other selected nuclei in the human medulla. Brain Res 1988;447:287-292.
Ishizuka Y, Ishida Y, Kunitake T, et al. Effects of area postrema lesion and abdominal vagotomy on interleukin-1 beta-induced norepinephrine release in the hypothalamic paraventricular nucleus region in the rat. Neurosci Lett 1997;223:57-60.
Jansson L, Holmdahl R. Estrogen-mediated immunosuppression in autoimmune diseases. Inflamm. Res 1998;47:290-301.
Karalis K, Muglia LJ, Bae D, et al. CRH and the immune system. J Neuroimmunol 1997;72:131-136.
Koj A. Initiation of acute phase response and synthesis of cytokines. Biochim Biophys Acta 1996;1317:84-94.
Krahl SE, Clark KB, Smith DC, et al. Locus coeruleus lesions suppress the seizure-attenuating effects of vagus nerve stimulation. Epilepsia 1998;39;709-714.
Kronfol Z. Immune dysregulation in major depression: a critical review of existing evidence. Int. J. Neuropsychopharmacol 2002;5:333-343.
Kronfol Z, Remick DG. Cytokines and the brain: implications for clinical psychiatry. Am J Psychiatry 2000;157:683-694.
Lawrence AJ, Jarrott B. Neurochemical modulation of cardiovascular control in the nucleus tractus solitarius. Prog. Neurobiol 1996;48:21-53.
Leonard S, BertranD D. Neuronal nicotinic receptors: from structure to function. Nicotine Tob Res 2001;3:203-223.
Lewis MW, Travagli RA. Effects of substance P on identified neurons of the rat dorsal motor nucleus of the vagus. Am J Physiol Gastrointest Liver Physiol 2001;281:G164-G172.
Lilly MP, Gann DS. The hypothalamic-pituitary-adrenal-immune axis. A critical assessment. Arch Surg 1992;127:1463-1474.
Lindstrom J. Nicotinic acetylcholine receptors in health and disease. Mol Neurobiol 1997;15:193-222.
Lipton JM, Catania A. Anti-inflammatory actions of the neuroimmunomodulator alpha-MSH. Immunol Today 1997;18:140-145.
Macaluso A, Mccoy D, Ceriani G, et al. Antiinflammatory influences of alpha-MSH molecules: central neurogenic and peripheral actions. J. Neurosci 1994;14:2377-2382.
Madden KS, Sanders VM, Felten DL. Catecholamine influences and sympathetic neural modulation of immune responsiveness. Annu Rev Pharmacol Toxicol 1995;35:417-448.
Martiney JA, Rajan AJ, Charles PC, et al. Prevention and treatment of experimental autoimmune encephalomyelitis by CNI-1493, a macrophage- deactivating agent. J Immunol 1998;160:5588-5595.
Marubio LM, Changeux J. Nicotinic acetylcholine receptor knockout mice as animal models for studying receptor function. Eur J Pharmacol 2000;393:113-121.
Mascarucci P, Perego C, Terrazzino S, De Simoni MG. Glutamate release in the nucleus tractus solitarius induced by peripheral lipopolysaccharide and interleukin-1 beta. Neuroscience 1998;86:1285-1290.
Mcewen BS, Biron CA, Brunson KW, et al. The role of adrenocorticoids as modulators of immune function in health and disease: neural, endocrine and immune interactions. Brain Res Rev 1997;23:79-133.
Mckay Li, Cidlowski JA. Molecular control of immune/inflammatory responses: interactions between nuclear factor-kappa B and steroid receptor- signaling pathways. Endocr Rev 1999;20:435-459.
Meistrell ME III, Botchkina GI, Wang H, et al. Tumor necrosis factor is a brain damaging cytokine in cerebral ischemia. Shock 1997;8:341-348.
Me DR. Tumor necrosis factor in the heart. Am. J. Physiol 1998;274:R577- R595.
Mira Y, Aznar J, Estelles A, et al. Congenital and acquired thrombotic risk factors in women using oral contraceptives: clinical aspects. Clin Appl Thromb Hemost 2000;6:162-168.
Mita Y, Dobashi K, Suzuki K, et al. Induction of muscarinic receptor subtypes in monocytic/macrophagic cells differentiated from EoL-1 cells. Eur J Pharmacol 1996;297:121-127.
Mulla A, Buckingham JC. Regulation of the hypothalamo-pituitary-adrenal axis by cytokines. Baillieres Best Pract Res Clin Endocrinol Metab 1999;13:503-521.
Nadeau S, Rivest S. Effects of circulating tumor necrosis factor on the neuronal activity and expression of the genes encoding the tumor necrosis factor receptors (p55 and p75) in the rat brain: a view from the blood-brain barrier. Neuroscience 1999;93:1449-1464.
Naritoku DK, Terry WJ, Helfert RH. Regional induction of fos immunoreactivity in the brain by anticonvulsant stimulation of the vagus nerve. Epilepsy Res 1995;22:53-62.
Niijima A, Hori T, Katafuchi T, Ichijo T. The effect of interleukin-1 beta on the efferent activity of the vagus nerve to the thymus. J Auton Nerv Syst 1995;54:137-144.
Ohyama K, Kawamura K. Coordinate expression of beta1 integrins and their regulator, TGF beta2 at the floor plate of the medulla oblongata is correlated with the crossing of the fibers of olivocerebellar projection in mice. Brain Res Dev Brain Res 2002;133:77-80.
Orr-Urtreger A, Goldner FM, Saeki M, et al. Mice deficient in the alpha7 neuronal nicotinic acetylcholine receptor lack alpha-bungarotoxin binding sites and hippocampal fast nicotinic currents. J Neurosci 1997;17: 9165-9171.
Ostensen M, Forger F, Nelson JL, et al. Pregnancy in patients with rheumatic disease: anti-inflammatory cytokines increase in pregnancy and decrease post partum. Ann Rheum Dis 2005;64:839-844.
Pavlov VA, Wang H, Czura CJ, et al. The cholinergic anti-inflammatory pathway: a missing link in neuroimmunomodulation. Mol Med 2003;9:125-134.
Pavón L, Hernández ME, Loría F, Sandoval G: Interacciones neuroendocrinoinmunologicas. Salud Mental 2004;27:19-25.
Perlstein RS, WHitnall MH, Abrams JS, et al. Synergistic roles of interleukin- 6, interleukin-1, and tumor necrosis factor in the adrenocorticotropin response to bacterial lipopolysaccharide in vivo. Endocrinology 1993;132:946-952.
Reichlin S. Neuroendocrine-immune interactions. N Engl J. Med 1993; 329:1246-1253.
Rivest S. How circulating cytokines trigger the neural circuits that control the hypothalamic-pituitary-adrenal axis. Psychoneuroendocrinology 2001;26:761-788.
Rivest S, Lacroix S, Vallieres L, et al. How the blood talks to the brain parenchyma and the paraventricular nucleus of the hypothalamus during systemic inflammatory and infectious stimuli. Proc Soc Exp Biol Med 2000;223:22-38.
Rogers RC, Hermann GE, Travagli, RA. Brainstem pathways responsible for oesophageal control of gastric motility and tone in the rat. J Physiol 1999;514(Pt 2):369-383.
Rogers RC, Mccann MJ. Intramedullary connections of the gastric region in the solitary nucleus: a biocytin histochemical tracing study in the rat. J Auton Nerv Syst 1993;42:119-130.
Sato KZ, Fujii T, Watanabe Y, et al. Diversity of mRNA expression for muscarinic acetylcholine receptor subtypes and neuronal nicotinic acetylcholine receptor subunits in human mononuclear leukocytes and leukemic cell lines. Neurosci Lett 1999;266:17-20.
Scheinman RI, Cogswell PC, Lofquist AK, et al. Role of transcriptional activation of I kappa B alpha in mediation of immunosuppression by glucocorticoids. Science 1995;270:283-286.
Shihara M, Hori N, Hirooka Y, et al. Cholinergic systems in the nucleus of the solitary tract of rats. Am J Physiol 1999;276:R1141-R1148.
Srivastava S, Weitzmann MN, Cenci S, et al. Estrogen decreases TNF gene expression by blocking JNK activity and the resulting production of c-Jun and JunD. J Clin Invest 1999;104:503-513.
Steinlein O. New functions for nicotinic acetylcholine receptors?. Behav Brain Res 1998;95:31-35.
Strom TB, Deisseroth A, Morganroth J, et al. Alteration of the cytotoxic action of sensitized lymphocytes by cholinergic agents and activators of adenylate cyclase. Proc Natl Acad Sci. USA 1972;69:2995-2999.
Sykes RM, Spyer KM, Izzo PN. Demonstration of glutamate immunoreactivity in vagal sensory afferents in the nucleus tractus solitarius of the rat. Brain Res 1997;762:1-11.
Szelenyi J. Cytokines and the central nervous system. Brain Res Bull 2001;54:329-338.
Tayebati SK, EL-Assouad D, Ricci A, Amenta F. Immunochemical and immunocytochemical characterization of cholinergic markers in human peripheral blood lymphocytes. J Neuroimmunol 2002;132:147-155.
Terao A, Oikawa M, Saito M. Cytokine-induced change in hypothalamic norepinephrine turnover: involvement of corticotropin-releasing hormone and prostaglandins. Brain Res 1993;622:257-261.
Torre-Amione G, Kapadia S, Lee J, et al. Expression and functional significance of tumor necrosis factor receptors in human myocardium. Circulation 1995;92:1487-1493.
Toyabe S, Iiai T, Fukuda M, et al. Identification of nicotinic acetylcholine receptors on lymphocytes in the periphery as well as thymus in mice. Immunology 1997;92:201-205.
Tracey KJ. Suppression of TNF and other proinflammatory cytokines by the tetravalent guanylhydrazone CNI-1493. Prog Clin Biol Res 1998;397:335-343.
Tracey KJ. The inflammatory reflex. Nature 2002;420:853-859.
Tracey KJ, Beutler B, Lowry SF, et al. Shock and tissue injury induced by recombinant human cachectin. Science 1986;234:470-474.
Tracey KJ, Czura CJ, Ivanova S. Mind over immunity. FASEB J 2001;15:1575-1576.
Tracey KJ, Fong Y, Hesse DG, et al. Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia. Nature 1987;330:662-664.
Valencia I, Holder DL, Helmers SL, et al. Vagus nerve stimulation in pediatric epilepsy: a review. Pediatr Neurol 2001;25:368-376.
Van Dam AM, Bol JG, Gaykema RP, et al. Vagotomy does not inhibit high dose lipopolysaccharide-induced interleukin-1beta immunoreactivity in rat brain and pituitary gland. Neurosci Lett 2000;285:169-172.
Van Der PT, Coyle SM, Barbosa K, et al. Epinephrine inhibits tumor necrosis factor-alpha and potentiates interleukin 10 production during human endotoxemia. J Clin Invest 1996;97:713-719.
Visconti E, Celentano LP, Tamburrini E, et al. Combination antiretroviral therapy in human immunodeficiency virus-infected pregnant women. Obstet Gynecol 2000;95:636-637.
Walch L, Brink C, Norel X. The muscarinic receptor subtypes in human blood vessels. Therapie 2001;56:223-226.
Wang H, Bloom O, Zhang M, et al. HMG-1 as a late mediator of endotoxin lethality in mice. Science 1999;285: 248-251.
Wang H, Li W, Goldstein R, et al. HMGB1 as a potential therapeutic target. Novartis Found Symp 2007;280:73-85.
Wang H, Yang H, Czura CJ, et al. HMGB1 as a late mediator of lethal systemic inflammation. Am J Respir Crit Care Med 2001;164:1768-1773.
Wang H, Yu M, Ochani M, et al. Nicotinic acetylcholine receptor alpha7 subunit is an essential regulator of inflammation. Nature 2003;421:384-388.
Wang H, Zhang M, Bianchi M, et al. Fetuin (alpha2-HS-glycoprotein) opsonizes cationic macrophage deactivating molecules. Proc Natl Acad Sci USA 1998;95:14429-14434.
Watkins LR, Maier SF, Goehler LE. Cytokine-to-brain communication: a review & analysis of alternative mechanisms. Life Sci 1995;57:1011-1026.
Webster JI, Tonelli L, Sternberg EM. Neuroendocrine regulation of immunity. Annu Rev Immunol 2002;20:125-163.
Zhou M, Yang S, Koo DJ, et al. The role of Kupffer cell alpha(2)-adrenoceptors in norepinephrine-induced TNF-alpha production. Biochim Biophys Acta 2001;1537:49-57.
Zhu C, Liu Q, Wei Y, et al. Coexistence of immune-neuro-endocrine substances in the rat central neurons. J Tongji Med Univ 1999;19:81-85.