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2008, Número 1

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Rev Endocrinol Nutr 2008; 16 (1)


Aspectos genéticos de la hiperlipidemia familiar combinada

Huertas-Vázquez A

Idioma: Español
Referencias bibliográficas: 83
Paginas: 16-23
Archivo PDF: 142.25 Kb.


RESUMEN

La hiperlipidemia familiar combinada, es la forma más común de las dislipidemias familiares de origen genético, que constituye un factor de riesgo para el desarrollo de la enfermedad arterial coronaria prematura. La hiperlipidemia familiar combinada se caracteriza por la expresión variable de hipercolesterolemia y/o hipertrigliceridemia. Estudios genéticos realizados en diferentes poblaciones han identificado regiones cromosómicas y variantes genéticas que confieren susceptibilidad para el desarrollo de este padecimiento. La presente revisión está enfocada al estudio de las bases genéticas de esta dislipidemia común y destaca el progreso en la identificación de genes de susceptibilidad para la hiperlipidemia familiar combinada en familias mexicanas.


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