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2008, Número 1

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Bioquimia 2008; 33 (1)


Alteración de la integridad de las uniones estrechas en el desarrollo del cáncer. El papel de las claudinas

Zavala-Zendejas VE, Rendón-Huerta EP

Idioma: Español
Referencias bibliográficas: 53
Paginas: 19-29
Archivo PDF: 196.92 Kb.


RESUMEN

Las uniones estrechas (UE) restringen la difusión de solutos por el espacio paracelular confiriendo la propiedad de barrera a los epitelios y endotelios. La pérdida de la función normal de las UE es un paso importante en la progresión del cáncer, ya que se compromete la compartamentalización creada por los epitelios, modificando el microambiente de dichos tejidos. La función de las UE se encuentra comprometida por cambios en la expresión y/o localización de las claudinas, las proteínas transmembranales que constituyen los principales elementos estructurales de dichas uniones. Sin embargo, las alteraciones en la expresión de las claudinas en el cáncer parecen influir en otros procesos importantes para la progresión tumoral y no sólo en la modificación de la homeostasis en los tejidos. El presente trabajo da una idea general del papel que juegan estas proteínas en algunas de las etapas de dicha progresión, los mecanismos involucrados en la regulación de su expresión y localización y su posible uso para el diagnóstico y terapia en diferentes tipos de cáncer.


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