2005, Número 1
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Rev Fac Med UNAM 2005; 48 (1)
Sepsis. Conceptos actuales (segunda de dos partes)
Carrillo ER, Carvajal RR
Idioma: Español
Referencias bibliográficas: 50
Paginas: 24-29
Archivo PDF: 55.70 Kb.
FRAGMENTO
La sepsis es secundaria a infecciones que ocurren a cualquier nivel pero está más frecuentemente asociada a infecciones respiratorias, abdominales y bacteremias. En el estudio de vigilancia epidemiológica NNIS realizado entre enero de 1992 a julio de 1997 en 97 hospitales de los Estados Unidos se incluyeron 181,993 pacientes de 112 unidades de cuidados intensivos, de los cuales se registraron 14,177 infecciones siendo las más frecuentes: infección urinaria 31%, infección respiratoria 27%, bacteremia nosocomial 19%, lo cual representó el 77% de todas las infecciones nosocomiales. En el estudio europeo de prevalencia de infecciones en las que se incluyeron a 1,417 unidades de terapia intensiva de 17 países se incluyeron a 10,038 enfermos, las infecciones más frecuentes fueron: neumonía 46.9%, bronquitis 17.8%, infección urinaria 17.6% y bacteremia primaria 12%. Las bacterias Gram negativas y Gram positivas son responsables de cerca del 80% de los casos a nivel hospitalario y el resto a hongos, parásitos y virus.
REFERENCIAS (EN ESTE ARTÍCULO)
Appelgren P, Hellstrom I, Wetzberg E et al. Risk Factors For Nosocomial Intensive Care Infection: A Long-Term Prospective Analysis. Acta Anaesthesiol Scand 2001; 45: 710-719.
Reinhart K, Bayer O, Brunkhorst F, Meisner M. Markers of endothelial damage in organ dysfunction and sepsis. Crit Care Med 2002; 30: S302-S312.
Boldt J, Muller M, Kuhn D et al. Circulating adhesion molecules in the critically ill: a comparison between trauma and sepsis patients. Intensive Care Med 1996; 22:122-128.
Fourrier F, Chopin C, Goudemand J et al. Septic shock, multiple organ failure, and disseminated intravascular coagulation. Compared patterns of antithrombin III, protein C, and protein S deficiencies. Chest 1992; 101: 816-823.
Pettila V, Hynninen M, Takkunen O et al. Predictive value of procalcitonin and interleukin 6 in critically ill patients with suspected sepsis. Intensive Care Med 2002; 28: 1220-1225.
Panacek EA, Kaul M. IL-6 as a marker of excessive TNF-a activity in sepsis. Sepsis 1999; 3: 65-73.
Povoa P, Almeida E, Moreira P et al. C-reactived protein as an indicator of sepsis. Intensive Care Med 1998; 24: 1052-1056.
Ugarte H, Silva E, Mercan D et al. Procalcitonin usage as a marker of infectious in the ICU. Crit Care Med 1999; 27: 498-504.
Weinstein MP, Reller LP, Murphy JR et al. The clinical significance of positive blood cultures: A comprehensive analysis of 500 episodes of bacteremia and fungemia in adults. I. Laboratory and epidemiologic observations. Rev Infect Dis 1983; 5: 35-53.
McCabe WR, Jackson GG. Gram negative bacteremia. Arch Intern Med 1962; 110: 92-100.
Kreger BE, Craven DE, McCabe WR. Gram negative bacteremia. IV. Re-evaluation of clinical features and treatment in 612 patients. Am J Med 1980; 68: 344-355.
Leibovici L, Shraga I, Drucker M et al. The benefit of appropriate empirical antibiotic treatment in patients with bloodstream infection. J Intern Med 1998; 244: 379-386.
Niederman MS, Fein AM. The Adults Respiratory Distress Syndrome, And Nosocomial Pneumonia: A Common Clinical Sequence. Clin Chest Med 1990; 11: 633-656.
Brismar B, Malmborg AS et al. Piperacilin-Tazobactam versus Imipenem-Cilastatin for treatment of Intra-Abdominal Infections. Antimicrobial Agents and Chemotherapy 1997; 36: 2766-2733.
Kollef M, Niederman M. Antimicrobial resistance in the ICU: The time for action is now. Crit Care Med 2001; 29: N63.
Niederman MS. Appropriate use of antimicrobial agents: Challenges and strategies for improvement. Crit Care Med 2003; 31: 608-616.
Leone M, Bourgoin A, Cambon S et al. Empirical antimicrobial therapy of septic shock patients: Adequacy and impact on the outcome. Crit Care Med 2003; 31: 462-467.
Kollef MH. Is there a role for antibiotic cycling in the intensive care unit? Crit Care Med 2001; 29: N135-N142.
Paterson DL. Restrictive antibiotic policies are appropriate in intensive care units. Crit Care Med 2003; 31: S25-S28.
Niederman MS. Impact of antibiotic resistance on clinical outcomes and the cost of care. Crit Care Med 2001; 29: N114-N120.
Wey SB, Mori M et al. Risk factors for hospital-acquired candidemia: A matched case-control study. Arch Intern Med 1989; 149: 2349-2353.
Jimenez MF, Marshall JC. Source control in the management of sepsis. Intensive Care Med 2001; 27: S49-S62.
Moss RL, Musemeche CA, Kosloske AM. Necrotizing fascitis in children: Prompt recognition and aggressive therapy improve survival. J Pediatr Surg 1996; 31: 1142-1146.
Rivers E, Nguyen B, Havstad S et al. Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med 2001; 345: 1368-1377.
Hollenberg SM, Ahrens TS, Astiz ME et al. Practice parameters for hemodynamic support of sepsis in adult patients. Crit Care Med 1999; 27: 639-660.
LeDoux D, Astiz ME, Carpati CM et al. Effects of perfusion pressure on tissue perfusion in septic shock. Crit Care Med 2000; 28: 2729-2732.
Martin C, Viviand X, Leone M et al. Effect of norepinephrine on the outcome of septic shock. Crit Care Med 2000; 28: 2758-2765.
Choi PTL, Yip G, Quinonez LG et al. Crystalloids vs colloids in fluid resuscitation: A systematic review. Crit Care Med 1999; 27: 200-210.
Cook D, Guyatt G. Colloid use for flui resuscitation: Evidence and spin. Ann Intern Med 2001; 135: 205-208.
Schierhout G, Roberts I. Fluid resuscitation with colloid or crystalloid solutions in critically ill patients: A systematic review of randomized trials. BMJ 1998; 316: 961-964.
De Backer D, Creteur J, Silva E et al. Effects of dopamine, norepinephrine, and epinephrine on the splachnic circulation in septic shock: Which is best? Crit Care Med 2003; 31: 1659-1667.
Holmes CL, Patel BM, Russell JA et al. Physiology of vasopressin relevant to management of septic shock. Chest 2001; 120: 989-1002.
Carrillo ER, Carvajal RR, Hernández AC. Vasopresina: una nueva alternativa terapéutica en el enfermo grave. Rev Asoc Mex Med Crit Int 2003; 5: 162-171.
Bellomo R, Chapman M, Finfer S et al. Low-dose dopamine in patients with early renal dysfunction: A placebo-controlled randomized trial. Australian and New Zealand Intensive Care Society (ANZICS) Clinical Trials Group. Lancet 2000; 356: 2139-2143.
Kellum J, Deckler J. Use of dopamine in acute renal failure: A meta-analysis. Crit Care Med 2001; 29: 1526-1531.
Hébert PC, Wells G, Blajchman MA et al. A multicenter, randomized, controlled clinical trial of transfusion in critical care. N Engl J Med 1999; 340: 409-417.
Marik PE, Sibbald WJ. Effect of stored-blood transfusion on oxygen delivery in patients with sepsis. JAMA 1993; 269: 3024-3029.
Lorente JA, Landín L, De Pablo R et al. Effects of blood transfusion on oxygen transport variables in severe sepsis. Crit Care Med 1003; 21: 1312-1318.
Brochard L, Roudat-Thoraval F, Roupie E et al. Tidal volume reduction for prevention of ventilator-induced lung injury in acute respiratory distress syndrome. The Multicenter Trial Group on Tidal Volume Reduction in ARDS. Am J Respir Crit Care Med 1998; 158: 1831-1838.
Brower RG, Shanholtz CB, Fessler HE et al. Prospective, randomized, controlled clinical trial comparing traditional versus reduced tidal volume ventilation in acute respiratory distress syndrome patients. Crit Care Med 1999; 27: 1492-1498.
Brower RG, Fessler HE. Mechanical ventilation in acute lung injury and acute respiratory distress syndrome. Clin Chest Med 2000; 21: 491-510.
Van den Berghe G, Wouters P, Weekers F et al. Intensive insulin therapy in the critically ill patients. N Engl J Med 2001; 345: 1359-1367.
Annane D, Sebille V, Charpentier C et al. Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock. JAMA 2002; 288: 862-871.
Briegel J, Forst H, Haller M et al. Stress doses of hydrocortisone reverse hyperdynamic septic shock: A prospective, randomized, double-blind, single-center study. Crit Care Med 1999; 27: 723-732.
Kanji S, Devlin J, Piekos K, Racin E. Recombinant human activated protein C, drotrecogin alfa (activated): A novel therapy for severe sepsis. Pharmacotherapy 2001; 21: 1389-1402.
Vincent JL, Angus DC, Artigas A, Kalil A et al. Effects of drotrecogin alfa (activated) on organ dysfunction in the PROWESS trial. Crit Care Med 2003; 31: 834-840.
Hotchkiss RS, Karl IE. The pathophysiology and treatment of sepsis. N Engl J Med 2003; 348: 138-151.
Laterre PF, Wittebole X. Clinical review: Drotrecogin alfa (activated) as adjunctive therapy for severe sepsis – practical aspects at the bedside and patient identification. Critical Care 2003; 7: 445-450.
Bernard GR, Vincent JL, Laterre PF, LaRosa SP et al. Efficacy and safety of recombinant human activated protein C for severe sepsis. N Engl J Med 2001; 344: 699-709.
Dellinger RP, Carlet JM, Masur H, Gerlach H et al. Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock. Crit Care Med 2004; 32: 858-872.