De la O-Arciniega M, Godínez-Chaparro B, Guevara-López U, Cortés-Arroyo AR, López-Muñoz FJ

Idioma: Español
Referencias bibliográficas: 51
Paginas: 363-369
Archivo PDF: 87.03 Kb.

RESUMEN

El dolor neuropático está asociado con una enfermedad o lesión en el sistema nervioso central o periférico; es considerado particularmente difícil de tratar debido a su etiología tan diversa y al mecanismo fisiopatológico subyacente. Datos clínicos y experimentales recientes soportan el potencial de la farmacoterapia combinada en este tipo de dolor. Con la finalidad de determinar la interacción sinérgica antihiperalgésica de la administración aguda individual y combinada de una dosis de morfina y gabapentina, fue evaluado el efecto antihiperalgésico de estos fármacos mediante la prueba de von Frey en un modelo de dolor neuropático en ratas (modelo de Bennett). El análisis de los cursos temporales mostró que la administración subcutánea individual de 3.2 mg/kg de morfina y de 17.8 mg/kg de gabapentina alcanzaron su máximo efecto a los 60 minutos postratamiento, produciendo un efecto antihiperalgésico de 51.7 ± 10.5 % y 55 ± 11.7 %, respectivamente. En tanto, la administración subcutánea de la combinación morfina + gabapentina (3.2 + 17.8 mg/kg) produjo un efecto antihiperalgésico casi total a los 30 minutos (96.7 ± 2.1 %) y a los 60 minutos registró 100 %, conservándose este efecto durante 180 minutos de observación. El análisis de los efectos globales como área bajo la curva de los cursos temporales, mostró que la interacción generada fue de suma para las dosis analizadas; la suma teórica de los efectos antihiperalgésico de los fármacos individuales (225.4 ± 29.1 unidades de área) no mostró diferencias significativas con el efecto producido por la combinación (263.33 ± 3.3 unidades de área). Estos resultados son de utilidad en el conocimiento de la interacción que genera la combinación de estos fármacos a las dosis estudiadas en dolor neuropático.

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