2006, Número 2
<< Anterior Siguiente >>
Gac Med Mex 2006; 142 (2)
Impacto de la duración de la psicosis no tratada en pacientes con primer episodio psicótico. Estudio de seguimiento a un año
Apiquián-Guitart R, Fresán-Orellana A, García-Anaya M, Lóyzaga-Mendoza C, Nicolini-Sánchez H
Idioma: Español
Referencias bibliográficas: 70
Paginas: 113-120
Archivo PDF: 497.34 Kb.
RESUMEN
Antecedentes: El retraso en la atención especializada conlleva a implicaciones pronósticas en los pacientes con trastornos psicóticos. La duración de la Psicosis No Tratada (DPNT) es un parámetro importante con valor pronóstico. Una DPNT larga se asocia con un peor pronóstico clínico.
Objetivo: Determinar la DPNT en un grupo de pacientes con primer episodio psicótico y determinar su influencia en los índices de recuperación y recaída a un año de seguimiento.
Material y métodos: Se incluyeron 66 pacientes en su primer episodio psicótico que agrupados en psicosis afectivas y no afectivas. El diagnóstico se efectuó con el SCAN. Se registró la DPNT y se evaluó la severidad de los síntomas psicóticos y afectivos con instrumentos validados en nuestro medio.
Resultados: Se observó mejoría sindromática global en los grupos diagnósticos. Los pacientes con DPNT larga presentaron menor ajuste psicosocial global y menor índice de recuperación. La suspensión del tratamiento fue el principal predictor de las recaídas.
Conclusiones: la DPNT es un importante factor asociado al pronóstico. El modelo de los estudios de detección temprana permite reducir el tiempo que tarda en tratarse la psicosis, e identificar oportunamente a los pacientes que han tenido el primer episodio psicótico.
REFERENCIAS (EN ESTE ARTÍCULO)
Jablensky A. Epidemiology of schizophrenia: the global burden of disease and disability. Eur Arch Psychiatry Clin Neurosci 2000; 250(6):274-285.
Rosenthal D. Role of heredity and upbringing in the development of schizophrenia. Vestn Akad Med Nauk SSSR 1971; 26(5):42-46.
Zubin J, Spring B. Vulnerability-a new view of schizophrenia. J Abnorm Psychol 1977;86(2):103-126.
Gottesman, II, Erlenmeyer-Kimling L. Family and twin strategies as a head start in defining prodromes and endophenotypes for hypothetical early-interventions in schizophrenia. Schizophr Res 2001; 51(1):93-102.
Mednick SA, Machon RA, Huttunen MO, Bonett D. Adult schizophrenia following prenatal exposure to an influenza epidemic. Arch Gen Psychiatry 1988;45(2)189-192.
Susser E, Neugebauer R, Hoek HW, Brown AS, Lin S, Labovitz D, et al. Schizophrenia after prenatal famine. Further evidence. Arch Gen Psychiatry 1996;53(1):25-31.
Kinney DK, Yurgelun-Todd DA, Waternaux CM, Matthysse S. Obstetrical complications and trail making deficits discriminate schizophrenics from unaffected siblings and controls. Schizophr Res 1994;12(1):63-73.
Andreasen NC. Symptoms, signs, and diagnosis of schizophrenia. Lancet 1995; 346(8973):477-481.
Griesinger W. Pathologie und Therapie psychischer Krankheiten. 2nd ed. Adolph Krabbe, Stuttgart., 1861
Kraepelin E. Psychiatrie. Ein Lehrbuch fu¨r Studierende und Aerzte.4th ed. Barth, Leipzig., 1893
Bleuler E. Dementia praecox oder Gruppe der Schizophrenien: In Aschaffenburg G. (ed.) Handbuch der Psychiatrie. Deuticke, Leipzig, 1911. p. 1–420.
Sullivan SH. The onset of schizophrenia. Am. J. Psychiatry 1927; 6:105–134.
Cameron DE. Early diagnosis of schizophrenia by the general practitioner. N. Engl. J. Med 1938;218:221-224.
Cameron DE. Early schizophrenia. Am. J. Psychiatry 1938; 95:567–578.
Conrad K. Die beginnende Schizophrenie.Versuch einer Gestaltanalyse des Wahns. Thieme-Verlag, Stuttgart, 1958.
Lieberman JA, Alvir JM, Woerner M, Degreef G, Bilder RM, Ashtari M, et al. Prospective study of psychobiology in first-episode schizophrenia at Hillside Hospital. Schizophr Bull 1992;18(3):351-371.
Robinson DG, Woerner MG, Alvir JM, Geisler S, Koreen A, Sheitman B, et al. Predictors of treatment response from a first episode of schizophrenia or schizoaffective disorder. Am J Psychiatry 1999;156(4):544-549.
McGorry PD."A stitch in time" ... the scope for preventive strategies in early psychosis. Eur Arch Psychiatry Clin Neurosci 1998;248(1):22-31.
Robinson D, Woerner MG, Alvir JM, Bilder R, Goldman R, Geisler S, et al. Predictors of relapse following response from a first episode of schizophrenia or schizoaffective disorder. Arch Gen Psychiatry 1999; 56(3):241-247.
Johnstone E, Crow T, Johnson A, MacMillan J. The NorthWick Park Study of First Episodes of Schizophrenia I. Presentation of the illness and Problems Relating to Admission. Br J Psychiatry 1986;148:115-120.
Loebel A, Lieberman J, Alvir J, Mayerhoff D, Geisler S, Szymanski S. Duration of psychosis and outcome in first-episode schizophrenia. Am J Psychiatry 1992;149:1183-1188.
Beiser M, Erickson D, Fleming JA, Iacono WG. Establishing the onset of psychotic illness. Am J Psychiatry 1993; 150(9):1349-1354.
Helgason L. Twenty years' follow-up of first psychiatric presentation for schizophrenia: what could have been prevented? Acta Psychiatr Scand 1990; 81(3):231-235.
Marneros A, Pillmann F, Haring A, Balzuweit S, Bloink R. Is the psychopathology of acute and transient psychotic disorder different from schizophrenic and schizoaffective disorders? Eur Psychiatry 2005; 20(4):315-320.
Pillmann F, Marneros A. Brief and acute psychoses: the development of concepts. Hist Psychiatry 2003;14(54 Pt 2):161-177.
Pillmann F, Haring A, Balzuweit S, Bloink R, Marneros A. Bouffee delirante and ICD-10 acute and transient psychoses: a comparative study. Aust N Z J Psychiatry 2003;37(3):327-333.
Loebel AD, Lieberman JA, Alvir JM, Mayerhoff DI, Geisler SH, Szymanski SR. Duration of psychosis and outcome in first-episode schizophrenia. Am J Psychiatry 1992;149(9):1183-1188.
Edwards J, Maude D, McGorry PD, Harrigan SM, Cocks JT. Prolonged recovery in first-episode psychosis. Br J Psychiatry Suppl 1998; 172(33):107- 116.
Wyatt RJ. Neuroleptics and the natural course of schizophrenia. Schizophr Bull 1991; 17(2):325-351.
Waddington JL, Youssef HA, Kinsella A. Sequential cross-sectional and 10-year prospective study of severe negative symptoms in relation to duration of initially untreated psychosis in chronic schizophrenia. Psychol Med 1995; 25(4):849-857.
Scully PJ, Coakley G, Kinsella A, Waddington JL. Psychopathology, executive (frontal) and general cognitive impairment in relation to duration of initially untreated versus subsequently treated psychosis in chronic schizophrenia. Psychol Med 1997; 27(6):1303-1310.
Keefe RS, Silva SG, Perkins DO, Lieberman JA. The effects of atypical antipsychotics drugs on neurocognitive impairment in schizophrenia: a review and meta-analysis. Schizophrenia Bulletin 1999; 25(2):201-222.
Waddington JL, Youssef HA, Dolphin C, Kinsella A. Cognitive dysfunction, negative symptoms, and tardive dyskinesia in schizophrenia. Their association in relation to topography of involuntary movements and criterion of their abnormality. Arch Gen Psychiatry 1987; 44(10):907-912.
Meltzer HY. What's atypical about atypical antipsychotic drugs? Curr Opin Pharmacol 2004; 4(1):53-57.
Lincoln C, Harrigan S, McGorry PD. Understanding the topography of the early psychosis pathways. An opportunity to reduce delays in treatment. Br J Psychiatry Suppl 1998;172(33):21-25.
Jones PB, Bebbington P, Foerster A, Lewis SW, Murray RM, Russell A, et al. Premorbid social underachievement in schizophrenia. Results from the Camberwell Collaborative Psychosis Study. Br J Psychiatry 1993; 162:65-71.
Yung A, McGorry P. The prodromal phase of first-episode psychosis:past and current conceptualizations. Schizophr Bull 1996; 22:352-370.
Keshavan M, Schooler N. First-Episode Studies in Schizophrenia : Criteria and Characterization. Schizophr Bull 1992;18:491-513.
Wing J, Babor T, Brugh A, Bruke J, Cooper J, Gieel R, et al. SCAN Schedules for Clinical Assessment in Neuropsychiatry. Arch Gen Psychiatry 1990;47:589-593.
Vázquez-Barquero J, Gaite L, Artal J, Diez Manrique J, Herrera Castanedo S, Williams Y. Report on the Spanish Translation of the SCAN, Schedules and Glossary. Santander, 1992.
Apiquian R, Páez F, Loyzaga C, Cruz E, Gutierrez D, Suárez J, et al. Estudio Mexicano del Primer Episodio Psicotico: Resultados preliminares, características sociodemográficas y clínicas. Salud Mental Supl 1997;20(3):1-7.
Apiquian R, Fresán A, Nicolini H. Evaluation of the Psychopathology. Rating Scales in Spanish. Mexico, JGH, 2000.
Kay SR, Fiszbein A, Vital-Herne M, Fuentes LS. The Positive and Negative Syndrome Scale-Spanish adaptation. Journal of Nervous & Mental Disease 1990;178(8):510-517.
Ortega-Soto HA GS, Imaz M, Pacheco J, Brunner E, Apiquian R, de la Torre MP. Validez y Reproductibilidad de una escala para evaluar depresión en la esquizofrenia. Salud Mental 1994;17(3):7-14.
Hamilton M. Development of a rating scale for primary depressive illness. Br J Soc Clin Psychol 1967;6:278-296.
Apiquian R, Tapia R, Paéz F, Fresán A, Vallejo G, Nicolini H. Validez y Confiabilidad de la Escala de Evaluación de Manía. Salud Mental 1997; 20:23-29.
Tohen M, Stoll A, Strakowski S, Glanni L, Mayer F, Goodwin D, et al. The McLean First-Episode Psychosis Project:Six Month Recovery and Recurrence Outcome. Schizophr Bull 1992;18:273-281.
Frank L, Prien R, Jarret R, Keller M, Kupfer D, Lavori P, et al. Conceptualization and rationale for consensus definitions of terms in major depressive disorder, remission, recovery, relapse and recurrence. Arch Gen Psychiatry 1991;48:851-855.
Strauss J, Carpenter W. The prediction of outcome in schizophrenia III. Five year outcome and its predictors. Arch Gen Psychiatry 1977;34:159-163.
Larsen T, McGlashan T, Moe L. First-Episode Schizophrenia: Early Course Parameters. Schizophr Bull 1996;22:241-256.
McGlashan T. Duration of untreated psychosis in first-episode schizophrenia: Marker or determinant of course. Biol Psychiatry 1999;46:899-907.
Larsen T, Moe L, Vibe-Hansen L, Johannessen J. Premorbid functioning versus duration of untreated psychosis in 1 year outcome in first-episode psychosis. Schizophr Res 2000;45:1-9.
Crow T. Nature of the genetic contribution to psychotic illness: A continuum viewpoint. Acta Psychiatr Scand 1990;81:401-408
Subotnik K, Nuechterlein K, Asarnow R. Depressive symptoms in the early course of schizophrenia:relationship to familial psychiatric illness. Am J Psychiatry 1997;154:1551-1556.
Geddes J, Kendell R. Schizophrenic subjects with no history of admission to hospital. Psychol Med 1995;25:859-868.
Ho B, Nopoulos P, Flaum M, Arndt S, Andreasen N. Two-year outcome in First-Episode Schizophrenia: Predictive Value of Symptoms for Quality of Life. Am J Psychiatry 1998;155:1196-1201.
Bromet E, Fennig S. Epidemiology and natural history of schizophrenia. Biol Psychiatry 1999; 46:871-881.
Geddes J, Mercer G, Frith C, MacMillan F, Owens D, Johstone E. Prediction of Outcome following a first episode of schizophrenia. A Followup study of Northwick Park First Episode Study Subjects. Br J Psychiatry 1994;165:664-668.
Addington D, Addington J, Patten S. Depression in people with firstepisode schizophrenia. Br J Psychiatry 1998;172:90-92.
Rabiner C, Wegner J, Kane J. Outcome Study of First-Episode Psychosis, I: Relapse Rates after 1 year. Am J Psychiatry 1986; 143:1155-1158.
Lieberman J, Jody D, Geisler S. Time course and biological correlates of treatment response in first-episode schizophrenia. Arch Gen Psychiatry 1993;50:369-376.
Lieberman J, Koreen A, Chakos M. Factors influencing treatment response and outcome of first-episode schizophrenia. J Clin Psychiatry 1996;57:5-9.
Gupta S, Andreasen N, Arndt S, Flaum M, Hubbard W, Ziebell S. The Iowa Longitudinal Study of Recent Onset Psychosis: One -year follow-up of first episode patients. Schizophr Res 1997;23:1-13.
Edwards J, Maude D, McGorry P, Harrigan S, Cocks J. Prolonged recovery in first-episode psychosis. Br J Psychiatry 1998;172:107-116.
Robinson D, Woerner M, Alvir J, Geisler S, Koreen A, Sheitman B, et al. Predictors of treatment response from a first episode of schizophrenia or schizoaffective disorder. Am J Psychiatry 1999;156:544-549.
Kissling W. Directrices para la prevención de recidivas de la esquizofrenia con neurolépticos. Springer-Verlag Iberica. Barcelona, 1994.
Weiden P, Olfson M. Cost of relapse in schizophrenia. Schizophr Bull 1995; 21:4119-4129.
McGorry. Psychoeducation in first-episode psychosis: a therapeutic process. Psychiatry 1995; 58:313-328.
Medina-Mora M, Rascon M, Tapia R, Mariño M, Juárez F, Villatoro J, et al. Trastornos emocionales en población urbana mexicana: resultados de un estudio nacional. Anales del IMP 1992; 2:48-55.
Salgado de Snyder V, Díaz-Pérez M, Maldonado M. Los nervios de las mujeres mexicanas de origen rural como motivo para buscar ayuda. Salud Mental 1995;18:50-55.