Plata PEJ, Gracida MNI, Rojero VJ, Hernández GMM, Lira DA, Fuentes MF

Idioma: Español
Referencias bibliográficas: 34
Paginas: 10-16
Archivo PDF: 169.57 Kb.

RESUMEN

Objetivo: Evaluar la cicatrización de una anastomosis colónica y la administración preoperatoria de polietilenglicol, fosfato de sodio, vía oral, y dieta líquida.
Sede: Cirugía Experimental. Hospital General de México, O.D.
Diseño: Modelo biológico experimental, de tipo prospectivo, comparativo, aleatorizado, doble ciego.
Análisis estadístico: Chi cuadrada.
Material y métodos: Tres grupos de cinco perros cada uno, G1 con dieta líquida, G2 con fosfato de sodio, VO, y G3 con polietilenglicol, VO. A todos se les administró antibiótico profiláctico y realizó sección y anastomosis término-terminal de un segmento de colon transverso. Tres semanas después se resecó la anastomosis colónica y evaluó, en forma macroscópica e histopatológica, las anastomosis. Variables: formación de colágena, edema de serosa, migración de fibroblastos, reacción peritoneal, edema submucoso, fistulización.
Resultados: La formación de colágena en anastomosis fue 20% menor en G1. Edema de la serosa, presente en 20% G1 y G2, y 40% G3. La migración de fibroblastos fue un 20% mayor para G2 y G3. En G2 hubo 40% más de formación de fibras de colágena. Reacción peritoneal en G1, un caso leve; G2, un caso moderado y dos casos en G3, uno leve y otro moderado. En los tres grupos se presentó edema a nivel de la submucosa. En ninguna de las variables estudiadas se presentó una diferencia estadísticamente significativa.
Conclusión: No existe una diferencia estadísticamente significativa a nivel de la cicatrización colónica entre la administración de polietilenglicol, fosfato de sodio, y dieta líquida.

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