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2024, Número 4

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Enf Infec Microbiol 2024; 44 (4)


Síndrome invasivo por Klebsiella pneumoniae hipervirulenta multidrogoresistente, recaída mortal después de tratamiento efectivo: un enemigo para nunca olvidar. Reporte de caso y revisión de la literature

Murillo MMA, Espir SMJ

Idioma: Español
Referencias bibliográficas: 56
Paginas: 186-194
Archivo PDF: 286.50 Kb.


RESUMEN

El síndrome invasivo por Klebsiella pneumoniae hipervirulenta representa un reto diagnóstico y terapéutico, su incidencia se ha incrementado incluso por fuera de Asia. Suele ser un microorganismo multisensible, pero su capacidad de captar material genético le permite expresar mecanismos de resistencia, lo que conlleva dificultad para su erradicación, infecciones más severas y alta mortalidad. La diabetes mellitus no controlada aumenta el riesgo de infección metastásica. El manejo parte de la sospecha clínica temprana, el abordaje multidisciplinario y el control eficaz de la carga bacteriana. Presentamos un caso de infección por Klebsiella pneumoniae hipervirulenta productora de betalactamasas de espectro extendido (BLEE) en una mujer con antecedentes de diabetes mellitus no controlada, quien presentó una recaída infecciosa inicialmente inadvertida, con desenlace fatal. Se describe su epidemiología, patogenia, presentación clínica, abordaje diagnóstico y terapéutico con el fin de proporcionar a la comunidad médica herramientas para un manejo oportuno del caso índice, así como un diagnóstico temprano de una posible recaída infecciosa, enfocado en reducir la alta morbimortalidad y secuelas severas de esta enfermedad.


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