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2022, Número 3

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Rev Méd Electrón 2022; 44 (3)


Efectos patogénicos de los productos finales de glicación avanzada en el proceso de envejecimiento-enfermedad

Rufín-Gómez LÁ, Martínez-Morejón A, Rufín-Bergado AM, Méndez-Martínez J, Farías-Ramírez JA

Idioma: Español
Referencias bibliográficas: 36
Paginas: 573-584
Archivo PDF: 874.56 Kb.


RESUMEN

Los productos finales de glicación avanzada -conocidos como productos de la reacción de Maillard-, formados por glicación directa no enzimática de azúcares reductores con grupos amino libres de proteínas, provocan cambios estructurales y funcionales en las mismas, cuya producción endógena es incrementada con la edad, el estrés oxidativo, así como por factores externos, provocando envejecimiento prematuro y enfermedades degenerativas. El objetivo de la revisión fue obtener una visión actualizada de los avances en investigaciones sobre los efectos de productos finales de glicación avanzada y su interrelación con el estrés oxidativo en el proceso de envejecimiento-enfermedad. En la revisión se consideraron los principales artículos más recientes sobre el tema en las bases de datos PubMed, SciELO, ClinicalKey y LILACS. Se evidencian los efectos patogénicos de los productos finales de glicación avanzada que contribuyen al estrés oxidativo y a la inflamación, de forma especial en el envejecimiento prematuro, diabetes, enfermedad cardiovascular y en otras enfermedades neurodegenerativas, como un aspecto preocupante en el tema del envejecimiento poblacional y su enorme costo para la sociedad futura.


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