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2024, Número 1

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Rev Med UAS 2024; 14 (1)


Señalización purinérgica: Rutas metabólicas y vías de señalización asociadas al cáncer

Martínez-Zavala R, Hernández-Aragón LG, Avelino-Cruz JE, Galindo-Ramírez F

Idioma: Español
Referencias bibliográficas: 86
Paginas: 87-102
Archivo PDF: 572.60 Kb.


RESUMEN

Las acciones de los receptores purinérgicos en las células dependen del subtipo de receptor, el tipo celular y de su condición (sana o tumoral). El objetivo de esta revisión es identificar y analizar las rutas metabólicas dependientes de la activación purinérgica aso-ciadas a la progresión del cáncer. En diferentes tipos de cáncer, se ha observado que el ATP está incrementado en el microambiente tumoral y participa en el mantenimiento, proliferación, migración y supervivencia de las células tumorales, a través de los receptores purinérgicos P2. Además, el ATP puede ser degradado a adenosina, la cual, se ha relacionado con la supervivencia y proliferación mediante la activación de receptores P1 en células cancerígenas. Se ha propuesto que la reducción de las concentraciones extracelu-las de ATP, adenosina y la activación de receptores purigérgicos sería de gran relevancia en la aplicación de diferentes tratamientos antitumorales.


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