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Colegio de Medicina Interna de México.

2024, Número 7

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Med Int Mex 2024; 40 (7)


Miocarditis por inhibidores del punto de control inmunitario: el futuro es hoy

Trujillo FD, Balderas GFL, Hernández VRO

Idioma: Español
Referencias bibliográficas: 126
Paginas: 413-429
Archivo PDF: 335.94 Kb.


RESUMEN

Antecedentes: La miocarditis por inhibidores del punto de control inmunitario es una complicación potencialmente fatal en el tratamiento de pacientes con enfermedad neoplásica avanzada, que cada vez se reporta más en todo el mundo debido a la evolución indómita de la quimioterapia.
Objetivo: Describir la epidemiología, fisiopatología, detección oportuna, cuadro clínico, diagnóstico y tratamiento de la miocarditis por inhibidores del punto de control inmunitario.
Metodología: Búsqueda exhaustiva en diversas bases de datos: PubMed, Google Scholar y ClinicalKey. Se seleccionaron artículos en inglés publicados de 2002 a 2023. Se utilizaron términos de acuerdo con el esquema MeSH: inhibidores del punto de control inmunitario, miocarditis, evento adverso relacionado con el sistema inmunitario.
Resultados: Se obtuvieron 899 artículos, de los que se seleccionaron 126, que incluyen revisiones de la bibliografía destacadas, estudios observacionales, revisiones sistemáticas, metanálisis, ensayos clínicos con distribución al azar, registros de pacientes y guías de práctica clínica internacionales. El resto de los artículos se excluyó por no cumplir los objetivos de la revisión.
Conclusiones: El diagnóstico oportuno de esta complicación inmunomediada permitirá su tratamiento temprano.


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