2003, Número 2
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Alerg Asma Inmunol Pediatr 2003; 12 (2)
Eosinófilos: Revisión de la literatura
Brito GF, Yamazaki MA, Espinosa PSS, Vázquez TO
Idioma: Español
Referencias bibliográficas: 41
Paginas: 11-17
Archivo PDF: 278.30 Kb.
RESUMEN
El eosinófilo es un granulocito pequeño derivado de la médula ósea, tiene una vida media en la circulación de 6 a 12 horas antes de migrar a los tejidos en donde permanece por varios días, su desarrollo en la médula ósea es estimulado por interleucina-5, interleucina 3 y factor estimulante de colonias granulocito-macrófago. Su núcleo bilobulado es característico y sus gránulos citoplásmicos son distintivos, estas proteínas granulares son responsables de muchas funciones proinflamatorias, principalmente en la patogénesis de las enfermedades alérgicas, como célula efectora de hipersensibilidad inmediata, así como en la muerte de parásitos. Los eosinófilos interactúan con otras células por la expresión de múltiples receptores en su superficie.
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