2002, Número S1
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Gac Med Mex 2002; 138 (S1)
Procesos malignos en niños
I. The Descriptive Epidemiology of Acute Promyelocytic Leukemia (APL) in the U.S. and Its Ethnic Diversity
II. Hodgkin’s Disease in Childhood
III. Análisis crítico de los factores de riesgo en leucemia aguda linfoblástica
IV. Tratamiento actual de la histiocitosis de células de Langerhans
Paredes-Aguilera R, Preston-Martin S, Douer D, Pogoda JM, Brenan B, López-Santiago N, Taboada-Meza C
Idioma: Español
Referencias bibliográficas: 65
Paginas: 83-93
Archivo PDF: 75.75 Kb.
FRAGMENTO
Introducción
Los estudios epidemiológicos han despertado interés sobre las variaciones en la incidencia y subtipos de las leucemias agudas (LAs) y los linfomas malignos, de acuerdo con las regiones geográficas y el origen étnico de las poblaciones estudiadas. Los resultados de series de grupos colaborativos y la experiencia de centros oncológicos aislados, han reportado una incidencia de leucemia aguda promielocítica (LAP) de 3 a 9 % en los subtipos de leucemia aguda mieloide en población pediátrica de origen caucásico. Esta es mucho menor que lo reportado en población mestiza en EUA, algunos países del sur de Europa y algunos países de América Latina (20-25%). Estos hallazgos sugieren una predisposición racial o geográfica a desarrollar LAP. De manera alternativa la distribución racial diferente, podría explicarse por factores nutricionales o ambientales con o sin una predisposición genética. El mismo fenómeno se ha observado en la enfermedad de Hodgkin, con inicio de la enfermedad en la etapa temprana de la vida y una mayor proporción de la variedad histológica de células mixtas en países en vías de desarrollo, en contraste con países desarrollados en donde la incidencia aumenta con la edad y se refiere un predominio de la variedad histológica de esclerosis nodular.
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