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TIP Revista Especializada en Ciencias Químico-Biológicas

2022, Número 1

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TIP Rev Esp Cienc Quim Biol 2022; 25 (1)


Películas orales ultradelgadas con extractos de Agastache mexicana con actividad hipnótica como potencial tratamiento del insomnio

Martínez-Cortés DM, Vera-Pérez J, Gómez-y-Gómez Y

Idioma: Español
Referencias bibliográficas: 40
Paginas: 1-9
Archivo PDF: 467.35 Kb.


RESUMEN

Las películas orales ultradelgadas son sistemas de administración novedosos que no requieren agua para ingerirlas, son de rápida liberación sistémica y permiten una dosificación cómoda y precisa, representan una opción para el suministro de metabolitos de plantas medicinales usadas para problemas de insomnio como Agastache mexicana. Sin embargo, la incorporación de moléculas complejas puede alterar la función de las películas. Por ello, el objetivo de esta investigación fue el análisis de la reacción fisicoquímica de las películas ultradelgadas de alginato de sodio y su actividad biológica al mezclarlas con los extractos etanólicos de A. mexicana. Se observó que después de integrar los extractos, las películas conservaron su morfología homogénea, grosor menor a 50 µm, y un tiempo de solubilidad por debajo de los 10 min., mientras que la dureza y la elasticidad se incrementaron más del 40% y 60% respectivamente. Mediante el uso de la espectroscopía infrarroja encontramos que los grupos funcionales de los extractos se conservan y no modifican la estructura química de las películas ultradelgadas. Adicionalmente, demostramos que las películas conservan el efecto hipnótico de Agastache mexicana, ya que los tiempos de latencia y de sueño en un modelo murino no sufrieron cambios significativos, lo que significa un potencial tratamiento de origen natural ante desórdenes del sueño como el insomnio.


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