2021, Número 2
<< Anterior
Revista Cubana de Obstetricia y Ginecología 2021; 47 (2)
Impacto de la enfermedad por COVID-19 en el embarazo
Mendoza QJ, Medina SC, Torres GS, Caballero AJ
Idioma: Español
Referencias bibliográficas: 74
Paginas: 1-20
Archivo PDF: 455.35 Kb.
RESUMEN
Introducción: A fines del 2019 en Wuhan-China se reportaron neumonías atípicas, un nuevo coronavirus era la causa, la designaron como SARS-CoV-2 y es responsable de millones de infecciones y miles de muertes en todo el mundo. Las mujeres embarazadas son consideradas una población vulnerable frente a infecciones virales del tracto respiratorio debido a los cambios fisiológicos en esta etapa.
Objetivos: Realizar una revisión bibliográfica para identificar el impacto de la infección por SARS-CoV2 durante el embarazo y su relación con las complicaciones maternas.
Métodos: Se realiza una revisión de la información en las bases de datos Medline/Pubmed, BVS y Scopus, mediante la utilización de los siguientes términos COVID-19, SARS-CoV-2, pregnancy.
Análisis y síntesis de la información: Las mujeres embarazadas generalmente cursan la enfermedad con formas leves, sin embargo, existe evidencia en la literatura revisada, que éstas mujeres tienen alto riesgo de complicaciones, tales como parto pretérmino y distrés fetal, por lo que se requiere monitoreo materno y fetal. Así mismo, no se ha encontrado evidencia de transmisión vertical.
Conclusiones: Se requiere una vigilancia tanto de la madre como de su producto, en el período de la enfermedad debido a que existe riesgo de sufrimiento fetal y parto pretérmino. No se ha encontrado suficiente evidencia que sugiera una posible transmisión vertical y su impacto en el recién nacido, por lo que se considera adecuado el parto vaginal como primera elección, y reservar el parto por cesárea solo cuando sea obstétricamente necesario.
REFERENCIAS (EN ESTE ARTÍCULO)
Zhu N, Zhang D, Wang W, Li X, Yang B, Song J, et al. A Novel Coronavirus from Patients with Pneumonia in China, 2019. N Engl J Med. 2020 [acceso 01/08/2020];382(8):727-33. Disponible en: https://pubmed.ncbi.nlm.nih.gov/31978945/
Su S, Wong G, Shi W, Liu J, Lai ACK, Zhou J, et al. Epidemiology, Genetic Recombination, and Pathogenesis of Coronaviruses. Trends Microbiol. 2016 [acceso 01/08/2020];24(6):490-502. Disponible en: https://pubmed.ncbi.nlm.nih.gov/27012512/
Li Q, Guan X, Wu P, Wang X, Zhou L, Tong Y, et al. Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus-Infected Pneumonia. N Engl J Med. 2020 [acceso 01/08/2020];382(13):1199-207. Disponible en: https://pubmed.ncbi.nlm.nih.gov/31995857
Abarzúa-Camus F. COVID-19 y Embarazo. Rev Chil Obstet Ginecol. 2020 [acceso 01/08/2020];85(2):110-4. Disponible en: https://scielo.conicyt.cl/scielo.php?script=sci_arttext&pid=S0717-7526202000020011
Chen N, Zhou M, Dong X, Qu J, Gong F, Han Y, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet Lond Engl. 2020 [acceso 01/08/2020];395(10223):507-13. Disponible en: https://pubmed.ncbi.nlm.nih.gov/32007143/
Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet Lond Engl. 2020 [acceso 01/08/2020];395(10223):497-506. Disponible en: https://pubmed.ncbi.nlm.nih.gov/31986264/
Poon LC, Yang H, Lee JCS, Copel JA, Leung TY, Zhang Y, et al. ISUOG Interim Guidance on 2019 novel coronavirus infection during pregnancy and puerperium: information for healthcare professionals. Ultrasound Obstet Gynecol. 2020 [acceso 01/08/2020];55(5):700-8. Disponible en: https://pubmed.ncbi.nlm.nih.gov/32160345/
Lu R, Zhao X, Li J, Niu P, Yang B, Wu H, et al. Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding. The Lancet. 2020 [acceso 01/08/2020];395(10224):565-74. Disponible en: https://pubmed.ncbi.nlm.nih.gov/32007145/
Lam TT-Y, Jia N, Zhang Y-W, Shum MH-H, Jiang J-F, Zhu H-C, et al. Identifying SARS-CoV-2-related coronaviruses in Malayan pangolins. Nature. 2020 [acceso 01/08/2020];583(7815):282-5. Disponible en: https://pubmed.ncbi.nlm.nih.gov/32218527/
Chu DK, Akl EA, Duda S, Solo K, Yaacoub S, Schünemann HJ, et al. Physical distancing, face masks, and eye protection to prevent person-to-person transmission of SARS-CoV-2 and COVID-19: a systematic review and meta-analysis. Lancet Lond Engl. 2020 [acceso 01/08/2020];395(10242):1973-87. Disponible en: https://pubmed.ncbi.nlm.nih.gov/32497510/
Ding S, Liang TJ. Is SARS-CoV-2 Also an Enteric Pathogen with Potential Fecal-Oral Transmission? A COVID-19 Virological and Clinical Review. Gastroenterology. 2020 [acceso 01/08/2020];159(1):53-61. Disponible en: https://pubmed.ncbi.nlm.nih.gov/32353371/
Hindson J. COVID-19: faecal–oral transmission? Nat Rev Gastroenterol Hepatol. 2020 [acceso 25/03/2020];1. Disponible en: https://pubmed.ncbi.nlm.nih.gov/32214231/
Del Rio C, Malani PN. COVID-19-New Insights on a Rapidly Changing Epidemic. JAMA. 2020 [acceso 28/02/2020]. Disponible en: https://pubmed.ncbi.nlm.nih.gov/32108857/
Lauer SA, Grantz KH, Bi Q, Jones FK, Zheng Q, Meredith HR, et al. The Incubation Period of Coronavirus Disease 2019 (COVID-19) From Publicly Reported Confirmed Cases: Estimation and Application. Ann Intern Med. 2020 [acceso 28/02/2020];172(9):577-82. Disponible en: https://pubmed.ncbi.nlm.nih.gov/32150748/
Wiersinga WJ, Rhodes A, Cheng AC, Peacock SJ, Prescott HC. Pathophysiology, Transmission, Diagnosis, and Treatment of Coronavirus Disease 2019 (COVID-19): A Review. JAMA. 2020 [acceso 01/08/2020]; Disponible en: https://pubmed.ncbi.nlm.nih.gov/32648899/
Hoffmann M, Kleine-Weber H, Schroeder S, Krüger N, Herrler T, Erichsen S, et al. SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor. Cell. 2020 [acceso 01/08/2020];181(2):271-280. Disponible en: https://pubmed.ncbi.nlm.nih.gov/32142651/
Sungnak W, Huang N, Bécavin C, Berg M, Queen R, Litvinukova M, et al. SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes. Nat Med. 2020 [acceso 01/08/2020];26(5):681-7. Disponible en: https://pubmed.ncbi.nlm.nih.gov/32327758/
Zou X, Chen K, Zou J, Han P, Hao J, Han Z. Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection. Front Med. 2020 [acceso 01/08/2020];14(2):185-92. Disponible en: https://pubmed.ncbi.nlm.nih.gov/32170560/
Mancia G, Rea F, Ludergnani M, Apolone G, Corrao G. Renin-Angiotensin-Aldosterone System Blockers and the Risk of Covid-19. N Engl J Med. 2020 [acceso 01/08/2020];382(25):2431-40. Disponible en: https://pubmed.ncbi.nlm.nih.gov/32356627/
Phoswa WN, Khaliq OP. Is pregnancy a risk factor of COVID-19? Eur J Obstet Gynecol Reprod Biol. 2020 [acceso 01/08/2020];252:605-9. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320674/
Zhao X, Jiang Y, Zhao Y, Xi H, Liu C, Qu F, et al. Analysis of the susceptibility to COVID-19 in pregnancy and recommendations on potential drug screening. Eur J Clin Microbiol Infect Dis. abril 2020 [acceso 01/08/2020]:1-12. Disponible en: https://pubmed.ncbi.nlm.nih.gov/32328850/
Turco MY, Moffett A. Development of the human placenta. Development. Nov 2019 [acceso 10/08/2020];146(22). Disponible en: https://dev.biologists.org/content/146/22/dev163428
Xu Z, Shi L, Wang Y, Zhang J, Huang L, Zhang C, et al. Pathological findings of COVID-19 associated with acute respiratory distress syndrome. Lancet Respir Med. 2020 [acceso 01/08/2020];8(4):420-2. Disponible en: https://pubmed.ncbi.nlm.nih.gov/32085846/
Tang N, Li D, Wang X, Sun Z. Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia. J Thromb Haemost JTH. 2020 [acceso 01/08/2020];18(4):844-7. Disponible en: https://pubmed.ncbi.nlm.nih.gov/32073213/
Klok FA, Kruip MJHA, van der Meer NJM, Arbous MS, Gommers DAMPJ, Kant KM, et al. Incidence of thrombotic complications in critically ill ICU patients with COVID-19. Thromb Res. 2020 [acceso 01/08/2020];191:145-7. Disponible en: https://pubmed.ncbi.nlm.nih.gov/32291094/
Muyayalo KP, Huang D-H, Zhao S-J, Xie T, Mor G, Liao A-H. COVID-19 and Treg/Th17 imbalance: Potential relationship to pregnancy outcomes. Am J Reprod Immunol. 2020 [acceso 01/08/2020];84(5):e13304. Disponible en: https://pubmed.ncbi.nlm.nih.gov/32662111/
Balandya E, Wieland-Alter W, Sanders K, Lahey T. Human seminal plasma fosters CD4(+) regulatory T-cell phenotype and transforming growth factor-β1 expression. Am J Reprod Immunol. 2012 [acceso 01/08/2020];68(4):322-30. Disponible en: https://pubmed.ncbi.nlm.nih.gov/22805500/
Figueiredo AS, Schumacher A. The T helper type 17/regulatory T cell paradigm in pregnancy. Immunology. 2016 [acceso 01/08/2020];148(1):13-21. Disponible en: https://pubmed.ncbi.nlm.nih.gov/26855005/
Jørgensen N, Persson G, Hviid TVF. The Tolerogenic Function of Regulatory T Cells in Pregnancy and Cancer. Front Immunol. 2019 [acceso 01/08/2020];10:911. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6517506/
Muyayalo KP, Li ZH, Mor G, Liao AH. Modulatory effect of intravenous immunoglobulin on Th17/Treg cell balance in women with unexplained recurrent spontaneous abortion. Am J Reprod Immunol. 2018 [acceso 01/08/2020];80(4):e13018. Disponible en: https://pubmed.ncbi.nlm.nih.gov/29984444/
Nakashima A, Shima T, Inada K, Ito M, Saito S. The balance of the immune system between T cells and NK cells in miscarriage. Am J Reprod Immunol. 2012 [acceso 01/08/2020];67(4):304-10. https://pubmed.ncbi.nlm.nih.gov/22364212/
Ito M, Nakashima A, Hidaka T, Okabe M, Bac ND, Ina S, et al. A role for IL-17 in induction of an inflammation at the fetomaternal interface in preterm labour. J Reprod Immunol. 2010 [acceso 01/08/2020];84(1):75-85. Disponible en: https://pubmed.ncbi.nlm.nih.gov/22364212/
Fu B, Tian Z, Wei H. TH17 cells in human recurrent pregnancy loss and pre-eclampsia. Cell Mol Immunol. 2014 [acceso 01/08/2020];11(6):564-70. Disponible en: https://pubmed.ncbi.nlm.nih.gov/25027967/
Eghbal-Fard S, Yousefi M, Heydarlou H, Ahmadi M, Taghavi S, Movasaghpour A, et al. The imbalance of Th17/Treg axis involved in the pathogenesis of preeclampsia. J Cell Physiol. 2019 [acceso 01/08/2020];234(4):5106-16. Disponible en: https://pubmed.ncbi.nlm.nih.gov/30277561/
Zeng H, Xu C, Fan J, Tang Y, Deng Q, Zhang W, et al. Antibodies in Infants Born to Mothers with COVID-19 Pneumonia. JAMA. Marzo 2020 [acceso 01/08/2020];323(18):1848-49. Disponible en: https://pubmed.ncbi.nlm.nih.gov/32215589/
Wang X, Wang D, He S. The role of a cytokine storm in severe COVID-19 disease in pregnancy. Am J Obstet Gynecol. Julio 2020 [acceso 14/07/2020];0(0). Disponible en: https://www.ajog.org/article/S0002-9378(20)30728-6/abstract https://pubmed.ncbi.nlm.nih.gov/32659225/
Vigil-De Gracia P, Caballero LC, Chinkee JN, Luo C, Sánchez J, Quintero A, et al. COVID-19 y embarazo. Revisión y actualización. Rev Peru Ginecol Obstet. 2020 [acceso 01/08/2020];66(2). Disponible en: https://www.flasog.org/static/COVID-19/SPOG-COVID-19-Editado-Final-con-flujograma.pdf
Breslin N, Baptiste C, Gyamfi-Bannerman C, Miller R, Martinez R, Bernstein K, et al. Coronavirus disease 2019 infection among asymptomatic and symptomatic pregnant women: two weeks of confirmed presentations to an affiliated pair of New York City hospitals. Am J Obstet Gynecol Mfm. 2020 [acceso 01/08/2020];2(2):100-18. Disponible en: https://pubmed.ncbi.nlm.nih.gov/32292903/
Yan J, Guo J, Fan C, Juan J, Yu X, Li J, et al. Coronavirus disease 2019 in pregnant women: a report based on 116 cases. Am J Obstet Gynecol. 2020 [acceso 01/08/2020];223(1):111.e1-111.e14. Disponible en: https://www.researchgate.net/publication/340869157_Coronavirus_disease_2019_COVID-19_in_pregnant_women_A_report_based_on_116_cases
Juan J, Gil MM, Rong Z, Zhang Y, Yang H, Poon LC. Effect of coronavirus disease 2019 (COVID-19) on maternal, perinatal and neonatal outcome: systematic review. Ultrasound Obstet Gynecol. 2020 [acceso 01/08/2020];56(1):15-27. Disponible en: https://obgyn.onlinelibrary.wiley.com/doi/full/10.1002/uog.22088
Stumpfe FM, Titzmann A, Schneider MO, Stelzl P, Kehl S, Fasching PA, et al. SARS-CoV-2 Infection in Pregnancy - a Review of the Current Literature and Possible Impact on Maternal and Neonatal Outcome. Geburtshilfe Frauenheilkd. 2020 [acceso 01/08/2020];80(4):380-90. Disponible en: https://pubmed.ncbi.nlm.nih.gov/32322107/
Liu Y, Chen H, Tang K, Guo Y. Clinical manifestations and outcome of SARS-CoV-2 infection during pregnancy. J Infect. 2020 Mar [acceso 19/07/2020];S0163-4453(20):30109-2. Disponible en: https://pubmed.ncbi.nlm.nih.gov/32145216/
Liu W, Wang J, Li W, Zhou Z, Liu S, Rong Z. Clinical characteristics of 19 neonates born to mothers with COVID-19. Front Med. Apr 2020 [acceso 01/08/2020];14(2):193-8. Disponible en: https://pubmed.ncbi.nlm.nih.gov/32285380/
Liu H, Liu F, Li J, Zhang T, Wang D, Lan W. Clinical and CT imaging features of the COVID-19 pneumonia: Focus on pregnant women and children. J Infect. 2020 [acceso 01/08/2020];80(5):e7-13. Disponible en: https://pubmed.ncbi.nlm.nih.gov/32732059/
Antoun L, Taweel NE, Ahmed I, Patni S, Honest H. Maternal COVID-19 infection, clinical characteristics, pregnancy, and neonatal outcome: A prospective cohort study. Eur J Obstet Gynecol Reprod Biol. Julio 2020 [acceso 01/08/2020];252:559-62. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7362841/
Liu D, Li L, Wu X, Zheng D, Wang J, Yang L, et al. Pregnancy and Perinatal Outcomes of Women with Coronavirus Disease (COVID-19) Pneumonia: A Preliminary Analysis. AJR Am J Roentgenol. 2020 [acceso 01/08/2020];215(1):127-32. Disponible en: https://pubmed.ncbi.nlm.nih.gov/32186894/
Zhang L, Jiang Y, Wei M, Cheng BH, Zhou XC, Li J, et al. Analysis of the pregnancy outcomes in pregnant women with COVID-19 in Hubei Province. Zhonghua Fu Chan Ke Za Zhi. 2020 [acceso 01/08/2020];55(3):166-71. Disponible en: https://pubmed.ncbi.nlm.nih.gov/32145714/
Zamaniyan M, Ebadi A, Aghajanpoor S, Rahmani Z, Haghshenas M, Azizi S. Preterm delivery, maternal death, and vertical transmission in a pregnant woman with COVID-19 infection. Prenat Diagn. [acceso 28/07/2020];n/a(n/a). Disponible en: https://obgyn.onlinelibrary.wiley.com/doi/abs/10.1002/pd.5713
Dong L, Tian J, He S, Zhu C, Wang J, Liu C, et al. Possible Vertical Transmission of SARS-CoV-2 From an Infected Mother to Her Newborn. JAMA. Mayo 2020 [acceso 01/08/2020];323(18):1846-48. DOI: http://dx.doi.org/10.1001/jama.2020.4621
Wang S, Guo L, Chen L, Liu W, Cao Y, Zhang J, et al. A Case Report of Neonatal 2019 Coronavirus Disease in China. Clin Infect Dis Off Publ Infect Dis Soc Am. 2020 [acceso 01/08/2020];71(15):853-7. Disponible en: https://pubmed.ncbi.nlm.nih.gov/32215581/
Patanè L, Morotti D, Giunta MR, Sigismondi C, Piccoli MG, Frigerio L, et al. Vertical transmission of coronavirus disease 2019: severe acute respiratory syndrome coronavirus 2 RNA on the fetal side of the placenta in pregnancies with coronavirus disease 2019–positive mothers and neonates at birth. Am J Obstet Gynecol MFM. Aug 2020;2(3):100145. DOI: http://dx.doi.org/10.1016/j.ajogmf.2020.100145
Dashraath P, Wong JLJ, Lim MXK, Lim LM, Li S, Biswas A, et al. Coronavirus disease 2019 (COVID-19) pandemic and pregnancy. Am J Obstet Gynecol. 2020 [acceso 01/08/2020];222(6):521-31. Disponible en: https://pubmed.ncbi.nlm.nih.gov/32217113/
Mullins E, Evans D, Viner RM, O’Brien P, Morris E. Coronavirus in pregnancy and delivery: rapid review. Ultrasound Obstet Gynecol Off J Int Soc Ultrasound Obstet Gynecol. 2020 [acceso 01/08/2020];55(5):586-92. Disponible en: https://pubmed.ncbi.nlm.nih.gov/32180292/
Schwartz DA. An Analysis of 38 Pregnant Women with COVID-19, Their Newborn Infants, and Maternal-Fetal Transmission of SARS-CoV-2: Maternal Coronavirus Infections and Pregnancy Outcomes. Arch Pathol Lab Med. Jul 2020 [acceso 01/08/2020];144(7):799-805. Disponible en: https://pubmed.ncbi.nlm.nih.gov/32180426/
Khan S, Peng L, Siddique R, Nabi G, Nawsherwan N, Xue M, et al. Impact of COVID-19 infection on pregnancy outcomes and the risk of maternal-to-neonatal intrapartum transmission of COVID-19 during natural birth. Infect Control Hosp Epidemiol. 2020 [acceso 01/08/2020];41(6):748-50. Disponible en: https://pubmed.ncbi.nlm.nih.gov/32279693/
Qi H, Luo X, Zheng Y, Zhang H, Li J, Zou L, et al. Safe delivery for pregnancies affected by COVID-19. BJOG Int J Obstet Gynaecol. 2020 [acceso 09/08/2020];127(8):927-9. Disponible en: https://pubmed.ncbi.nlm.nih.gov/32219995/
Practice Bulletin No. 171: Management of Preterm Labor. Obstetrics & Gynecology. 2016 [acceso 09/08/2020];(171). Disponible en: https://journals.lww.com/greenjournal/Fulltext/2016/10000/Practice_Bulletin_No__171__Management_of_Preterm.61.aspx
Akhtar H, Patel C, Abuelgasim E, Harky A. COVID-19 (SARS-CoV-2) Infection in Pregnancy: A Systematic Review. Gynecol Obstet Invest. Julio 2020 [acceso 09/08/2020];1-12. Disponible en: https://pubmed.ncbi.nlm.nih.gov/32728006/
Yoon SH, Kang JM, Ahn JG. Clinical outcomes of 201 neonates born to mothers with COVID-19: a systematic review. Eur Rev Med Pharmacol Sci. 2020 [acceso 09/08/2020];24(14):7804-15. Disponible en: https://pubmed.ncbi.nlm.nih.gov/32744708/
Neonatal Encephalopathy and Neurologic Outcome. 2 ed. Washington D.C.: ACOG; 2014. p. 236 [acceso 21/07/2020]. Disponible en: https://www.acog.org/store/products/clinical-resources/neonatal-encephelopathy-and-neurologic-outcome
Gravett C, Eckert LO, Gravett MG, Dudley DJ, Stringer EM, Mujobu TBM, et al. Non-reassuring fetal status: Case definition & guidelines for data collection, analysis, and presentation of immunization safety data. Vaccine. 2016 [acceso 09/08/2020];34(49):6084-92. Disponible en: https://pubmed.ncbi.nlm.nih.gov/27461459/
Parer JT, Livingston EG. What is fetal distress? Am J Obstet Gynecol. junio de 1990;162(6):1421-5. Disponible en: https://pubmed.ncbi.nlm.nih.gov/2193513/
Smith V, Seo D, Warty R, Payne O, Salih M, Chin KL, et al. Maternal and neonatal outcomes associated with COVID-19 infection: A systematic review. PLoS One. 2020 [acceso 09/08/2020]:e0234187-e0234187. Disponible en: https://pubmed.ncbi.nlm.nih.gov/32497090/
Lambelet V, Vouga M, Pomar L, Favre G, Gerbier E, Panchaud A, et al. SARS-CoV-2 in the context of past coronaviruses epidemics: Consideration for prenatal care. Prenat Diagn. [acceso 18/07/2020];n/a(n/a). Disponible en: https://obgyn.onlinelibrary.wiley.com/doi/abs/10.1002/pd.5759
Chen H, Guo J, Wang C, Luo F, Yu X, Zhang W, et al. Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records. The Lancet. 2020 [acceso 09/08/2020];395(10226):809-15. Disponible en: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)30360-3/fulltext
Rodríguez-Blanco N, Vegara-Lopez I, Aleo-Giner L, Tuells J. Scoping review of coronavirus case series (SARS-CoV, MERS-CoV and SARS-CoV-2) and their obstetric and neonatal results. Rev Esp Quimioter. Oct 2020 [acceso 21/07/2020];33(5):313-26. Disponible en: https://seq.es/abstract/rev-esp-quimioter-2020-july-20-2/ Epub 2020 Jul 20.
Capobianco G, Saderi L, Aliberti S, Mondoni M, Piana A, Dessole F, et al. COVID-19 in pregnant women: A systematic review and meta-analysis. Eur J Obstet Gynecol Reprod Biol. Sep 2020;252:543-58. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7363619/
Ashraf MA, Keshavarz P, Hosseinpour P, Erfani A, Roshanshad A, Pourdast A, et al. Coronavirus Disease 2019 (COVID-19): A Systematic Review of Pregnancy and the Possibility of Vertical Transmission. J Reprod Infertil. 2020 [acceso 09/08/2020];21(3):157-68. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7362089/
Cabero-Pérez MJ, Gómez-Acebo I, Dierssen-Sotos T, Llorca J. Infección por SARS-CoV-2 en el embarazo y posibilidad de transmisión al neonato: una revisión sistemática. Med Fam SEMERGEN. Junio 2020 [acceso 17/07/2020];46(Supl. 1):40-7. Disponible en: http://www.sciencedirect.com/science/article/pii/S1138359320302033
Ferrazzi EM, Frigerio L, Cetin I, Vergani P, Spinillo A, Prefumo F, et al. COVID-19 Obstetrics Task Force, Lombardy, Italy: Executive management summary and short report of outcome. Int J Gynecol Obstet. 2020 [acceso 09/08/2020];149(3):377-8. Disponible en: https://pubmed.ncbi.nlm.nih.gov/32267531/
Pissarra S, Rosário M, Moucho M, Soares H. Perinatal management of SARS-CoV-2 infection in a level III University Hospital: The Journal of Maternal-Fetal & Neonatal Medicine. 2020 [acceso 26/07/2020]. Disponible en: https://www.tandfonline.com/doi/full/10.1080/14767058.2020.1786526
Zaigham M, Andersson O. Maternal and perinatal outcomes with COVID-19: A systematic review of 108 pregnancies. Acta Obstet Gynecol Scand. 2020 [acceso 09/08/2020];99(7):823-9. Disponible en: https://pubmed.ncbi.nlm.nih.gov/32259279/
Alzamora MC, Paredes T, Caceres D, Webb CM, Valdez LM, La Rosa M. Severe COVID-19 during Pregnancy and Possible Vertical Transmission. Am J Perinatol. 2020 [acceso 09/08/2020];37(8):861-5. Disponible en: https://pubmed.ncbi.nlm.nih.gov/32305046/
Hantoushzadeh S, Shamshirsaz AA, Aleyasin A, Seferovic MD, Aski SK, Arian SE, et al. Maternal death due to COVID-19. Am J Obstet Gynecol. 2020 [acceso 26/07/2020];223(1):109.e1-109.e16. Disponible en: https://pubmed.ncbi.nlm.nih.gov/32360108/