Berrazueta JR

Idioma: Español
Referencias bibliográficas: 20
Paginas: 537-541
Archivo PDF: 68.77 Kb.

RESUMEN

El descubrimiento del óxido nítrico como una molécula liberada por el endotelio que relaja el músculo liso vascular, ha modificado el interés en el estudio de las numerosas funciones que realiza el endotelio. La falta de relajación a estímulos químicos o mecánicos en presencia de un endotelio intacto, o la alteración en la liberación de sustancias por parte de las células endoteliales, o la sobreexpresión de otras, son las circunstancias que hoy se conocen como disfunción endotelial. Su estudio permite identificar precozmente el daño arterial que se mantiene a lo largo de toda la enfermedad vascular.

REFERENCIAS (EN ESTE ARTÍCULO)

1. Berrazueta JR: El Nobel para el óxido nítrico. La injusta exclusión del Dr. Salvador Moncada. Rev Esp Cardiol 1999; 52: 221-226.

2. Palmer RMJ, Ferrige AG, Moncada S: Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature 1987; 327: 524-526.

3. Berrazueta JR, López Jaramillo P, Moncada S: El óxido nítrico: De vasodilatador endógeno a mediador biológico. Rev Esp Cardiol 1990; 43: 421-431.

4. Matz RL, Schott C, Stoclet JC, Andriantsitohaina R: Age-related endothelial dysfunction with respect to nitric oxide, endothelium-derived hyperpolarizing factor and cyclooxygenase products. Physiol Res 2000; 49: 11-8.

5. Berrazueta JR, Baghat K, Vallance P, McAllister R: Dose and time-dependency of the dilator effects of the endothelin antagonist BQ 123, in the human forearm. Br J Clin Pharmacol 1997; 44: 569-571.

6. Palmer RMJ, Rees DD, Ashton DS, Moncada S: L-Arginine is the physiological precursor for the formation of nitric oxide in the endothelium-dependent relaxation. Biochem Biophys Res Commun 1988; 153: 1251-1256.

7. Rees DD, Palmer RMJ, Hodson HF, Moncada S: A specific inhibition of nitric oxide formation from L-Arginine attenuates endothelium-dependent relaxation. Br J Pharmacol 1989; 96: 418-424.

8. Chand N, Altura BM: Acetylcholine and bradykinin relax intrapulmonary arteries by acting on endothelial cells: Role in lung vascular disease. Science 1981; 213: 1376-1379.

9. Ku D: Coronary vascular reactivity after acute myocardial ischemia. Science 1982; 218: 576-578.

10. Salas E, Berrazueta JR, Fleitas M, Poveda J, Ochoteco A, Amado J: Reduced endothelium-mediated relaxing responses in peripheral atherosclerotic arteries from patients with and without diabetes mellitus. Diabet Medicine 1992; 9: 875-876.

11. Salas E, Amado JA, Sánchez de Vega MJ, Poveda JJ, Berrazueta JR: Impaired vascular smooth muscle nitric oxide-dependent relaxation in human coronary arteries from Transplanted heart vasculopathy. Arch Inst Cardiol Mex 1997; 67: 11-16.

12. Menéndez JC, Casanova D, Amado JA, Salas E, García-Unzueta MT, Fernández F, Pérez de la Lastra L, Berrazueta JR: Effects of radiation on endothelial function. Int J Radiation Oncology Biol Phys 1998; 41: 905-913.

13. Berrazueta JR, Salas E, Amado JA, Sánchez de Vega MJ, Poveda JJ: Induction of nitric oxide synthase in human mammary arteries in vitro. Eur J Pharmacol 1994; 251: 303-305.

14. Ceballos C, Ribes C, García UM, Amado JA, Pérez J, Berrazueta JR: Venous endothelial function in postmenopausal women who arte receiving long term estrogen and progestagen therapy. Fertil Steril 2000; 74: 268-273.

15. Ceballos C, Ribes C, Amado JA, de Mier I, de Rozas LS, Berrazueta JR: Venous endothelial function in postmenopausal women after six months of tibolone therapy. Maturitas 2001; 39: 63-70.

16. Pérez GJ, Ceballos C, Vázquez L, Mier I, Amado JA, Ochoteco A, Poveda JJ, Berrazueta JR: The venodilator effect of furosemide is dependent of the endothelium release of NO. POSTER No. 45. Second International Congress on NO in Cardiovascular Regulation and Intensive Care. XIX Congress of the European Society of Cardiology - Stockholm, Sweden. August 29-30. 1997.

17. Collier JG, Lorge RE, Robinson BF: Comparison of effects of Tolesoxide, Prazosin, Glyceryl trinitrate and sodium nitroprusside on forearm arteries and dorsal hand veins of arm. Br J Clin Pharmacol 1978; 5: 35-44.

18. Soresen KE, Celermajer DS, Spiegelhalter DJ, Georgakopoulos D, Robinson J, Thomas O, Deanfield JE: Non-invasive measurement of human endothelium dependent arterial responses: accuracy and reproducibility. Br Heart J 1995; 74: 274-253.

19. Celermajer DS, Adams MR, Clarkson P, Robinson J, McCredie R, Donald A, Deanfield JE: Passive smoking and impaired endothelium dependent arterial dilatation in healthy young adults. N Engl J Med 1996; 334: 150-154.

20. Poveda JJ, Riestra A, Salas E, Cagigas ML, Amado JA, Berrazueta JR: Contribution of nitric oxide to exercise-induced changes in healthy volunteers: effects of acute and long-term physical training. Eur J Clin Invest 1997; 27: 967-971.