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2001, Número 5

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Rev Fac Med UNAM 2001; 44 (5)


Metabolismo energético y esteroidogénico de la placenta humana

Martínez F, Espinosa GMT, García C, Maldonado G, Milán R, Uribe A, Flores HO

Idioma: Español
Referencias bibliográficas: 48
Paginas: 201-206
Archivo PDF: 47.70 Kb.


RESUMEN

Las células del sinciciotrofoblasto obtienen el ATP a través de la glucólisis anaerobia. Sin embargo, aunque las mitocondrias de la placenta sintetizan ATP, éste no participa en los procesos citoplasmáticos. Nuestros datos muestran la presencia de una ATP-difosfohidrolsa (apirasa) asociada a las mitocondrias de la placenta, que se inhibe por vanadato y FSBA. En este trabajo proponemos la hipótesis de que la apirasa y el ATP que sintetizan las mitocondrias de las células del sinciciotrofoblasto están asociados al transporte de colesterol necesario para la síntesis de progesterona, y que el uso del ATP y la actividad de la apirasa están asociados a los puntos de unión mitocondriales.


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