medigraphic.com
ISSN 1561-2996 (Digital)
ISSN 0864-0289 (Impreso)

2020, Número 4

<< Anterior Siguiente >>

Rev Cubana Hematol Inmunol Hemoter 2020; 36 (4)


Utilidad diagnóstica del dímero D cuantitativo

Miguel MM, Agramonte LOM, Tamayo RY

Idioma: Español
Referencias bibliográficas: 42
Paginas: 1-17
Archivo PDF: 293.78 Kb.


RESUMEN

Introducción: El dímero D es un marcador de la generación de trombina y plasmina. Constituye el producto final de la degradación de un trombo rico en fibrina mediada por la acción secuencial de 3 enzimas: trombina, factor FXIIIa y plasmina. Las pruebas disponibles en la actualidad para el diagnóstico del dímero D son variadas y no son uniformes.
Objetivo: Analizar las evidencias disponibles sobre la utilidad de diferentes pruebas rápidas de dímero D.
Métodos: Se realizó una revisión de la literatura de los últimos diez años, en inglés y español, utilizando motores de búsqueda como Google Académico y Pubmed que permitió el acceso a artículos relacionados en revistas arbitradas. Se agrupó y organizó información sobre las posibles utilidades del dímero D.
Desarrollo: La determinación en el laboratorio del dímero D, se usa como prueba rápida y sencilla, posee un lugar definido en los algoritmos de exclusión de la enfermedad tromboembólica venosa, en el diagnóstico de coagulación intravascular diseminada y con aplicación en la predicción de la recidiva de trombosis venosa profunda, en los últimos años. Existen diversos ensayos para la determinación de la concentración plasmática de dímero D que utilizan distintas metodologías, diferentes anticuerpos y sensibilidades.
Conclusiones: La determinación de dímero D por los métodos cuantitativos en pacientes con trastornos trombóticos es muy importante para determinar su sensibilidad, y fundamentar el desarrollo del algoritmo diagnóstico de las mencionadas entidades.


REFERENCIAS (EN ESTE ARTÍCULO)

  1. Mosesson MW. Fibrinogen and fibrin structure and functions. J Thromb Haemost. 2005;3:1894-904.

  2. Doolittle RF, Pandi L. Probing the beta-chain hole of fibrinogen with synthetic peptides that differ at their amino termini. Biochemistry.2007;46:10033-8.

  3. Versteeg HH, Heemskerk JW, Levi M, Reitsma PH. New fundamentals in hemostasis. Physiol Rev. 2013 Jan;93(1):327-58. DOI: https://10.1152/physrev.00016.2011

  4. Soheir SA, Nigel SK, Greenberg CS. D-dimer antigen: Current concepts and future prospects. Blood. 2009;113(13):2878-87.

  5. Parks C, Bounds R, Davis B, Caplan R, Laughery T, Zeserson E. Investigation of age-adjusted D-dimer using an uncommon assay. Am J Emerg Med. 2019 Jul;37(7):1285-88. DOI: http://10.1016/j.ajem.2018.09.035

  6. López-Salvio YM, Herrera-Rodríguez LJ, Guzmán-Silahua S, Nava-Zavala AH, Rubio-Jurado B. Dímero D: papel en patología trombótica. El Residente. 2018 Ene-Abr;13(1):12-22.

  7. Lippi G, Tripodi A, Simundic AM, Favaloro E. International Survey on D-Dimer Test Reporting: A Call for Standardization. Semin Thromb Hemost. 2015;41:287-93.

  8. Tripodi A. D-dimer testing in laboratory practice. Clin Chem. 2011 Sep;57(9):1256-62. DOI: http://10.1373/clinchem.2011.166249

  9. Dhakal P, Gundabolu K, Bhatt VR. An Algorithmic Approach to Management of Venous Thromboembolism. Clin Appl Thromb Hemost. 2017 Sep;23(6):511-517.

  10. Kleinjan A, Di Nisio M, Beyer-Westendorf J, Camporese G, Cosmi B, Ghirarduzzi A, et al. Safety and feasibility of a diagnostic algorithm combining clinical probability, d-dimer testing, and ultrasonography for suspected upper extremity deep venous thrombosis: a prospective management study. Ann Intern Med. 2014 Apr 1;160(7):451-7

  11. Bronic A, Coen Herak D, Margetic S, Milic M. Croatian Society of Medical Biochemistry and Laboratory Medicine: National recommendations for blood collection, processing, performance and reporting of results for coagulation screening assays prothrombin time, activated partial thromboplastin time, thrombin time, fibrinogen and D-dimer. Biochem Med (Zagreb). 2019 Jun 15;29(2):020503. DOI: http://10.11613/BM.2019.020503

  12. Aggett H, Dabula P, Mayne ES, Louw S. A pilot study to introduce a local external quality assurance scheme for D-dimers in the National Health Laboratory Service, in South Africa. Int J Lab Hematol. 2019 Apr;41(2):298-303. DOI: http://10.1111/ijlh.12973

  13. Rudolf JW, Baron JM, Dighe AS. Order Indication Solicitation to Assess Clinical Laboratory Test Utilization: D-Dimer Order Patterns as an Illustrative Case. J Pathol Inform. 2019 Dec;10:36.Disponible en: https://pubmed.ncbi.nlm.nih.gov/31897353/

  14. Berraondo Fraile J, Juan Samper G, Fernández-Fabrellas E, Konishi I, López Vázquez A, Bediaga Collado A, et al. Análisis de la utilización del dímero D en urgencias: ajuste por edad, uso inapropiado y predicción de extensión y gravedad de la embolia pulmonar. Emergencias 2016 Ago;28(4):223-8

  15. Barth BE, Waligora G, Gaddis GM. Rapid Systematic Review: Age-Adjusted D-Dimer for Ruling Out Pulmonary Embolism. J Emerg Med. 2018 Oct;55(4):586-92.DOI: http://10.1016/j.jemermed.2018.07.003

  16. Cate VT, Nagler M, Panova-Noeva M, Eggebrecht L, Arnold N, Lamparter H, et al. The diagnostic performance of renal function-adjusted D-dimer testing in individuals suspected of having venous thromboembolism. Haematologica. 2019Sep;104(9):e424-e427.

  17. Fronas SG, Wik HS, Dahm AEA, Jørgensen CT, Gleditsch J, Raouf N, et al. Safety of D-dimer testing as a stand-alone test for the exclusion of deep vein thrombosis as compared with other strategies. J Thromb Haemost. 2018Dec;16(12):2471-81.DOI: http://10.1111/jth.14314

  18. Greenberg CS, Devine DV, McCrae KM. Measurement of plasma fibrin D-dimer levels with the use of a monoclonal antibody coupled to latex beads. Am J Clin Pathol, 1987; 87:94-100.

  19. Bates SM, Takach Lapner S, Douketis JD, Kearon C, Julian J, Parpia S, et al. Rapid quantitative D-dimer to exclude pulmonary embolism: a prospective cohort management study. J Thromb Haemost. 2016 Mar;14(3):504-9. DOI: http://10.1111/jth.13234

  20. Roy PM, Revel MP, Salaün PY, Sanchez O; Groupe de travail Recommandations de bonne pratique pour la prise en charge de la MVTE. How to make the diagnosis of pulmonary embolism? Rev Mal Respir. 2019 Nov; S0761-8425(19)30187-1. French.

  21. Kearon C, de Wit K, Parpia S, Schulman S, Afilalo M, PEGeD Study Investigators, et al. Diagnosis of Pulmonary Embolism with d-Dimer Adjusted to Clinical Probability. N Engl J Med. 2019 Nov 28;381(22):2125-2134

  22. Sartori M, Migliaccio L, Favaretto E, Cini M, Legnani C, Palareti G, et al. D-dimer for the diagnosis of upper extremity deep and superficial venous thrombosis. Thromb Res. 2015 Apr;135(4):673-8. DOI: http://10.1016/j.thromres.2015.02.007

  23. Geersing GJ, Kraaijpoel N, Büller HR, van Doorn S, van Es N, Le Gal G, et al. Ruling out pulmonary embolism across different subgroups of patients and healthcare settings: protocol for a systematic review and individual patient data meta-analysis (IPDMA). Diagn Progn Res. 2018 Jul 2;2:10. DOI: http://10.1186/s41512-018-0032-7

  24. Schols AMR, Meijs E, Dinant GJ, Stoffers HEJH, Krekels MME, Cals JWL. General practitioner use of D-dimer in suspected venous thromboembolism: historical cohort study in one geographical region in the Netherlands. BMJ Open. 2019 May 28;9(5):e026846. DOI: http://10.1136/bmjopen-2018-026846

  25. Brown HL, Hiett AK. Deep vein thrombosis and pulmonary embolism in pregnancy: diagnosis, complications and management. Clin Obstet Gynecol 2010;53:345-59.

  26. Parakh RS, Sabath DE. Venous Thromboembolism: Role of the Clinical Laboratory in Diagnosis and Management. J Appl Lab Med. 2019 Mar;3(5):870-82. DOI: http://10.1373/jalm.2017.025734

  27. Le Gal G, Righini M, Roy PM, Sanchez O, Aujesky D, Perrier A, et al. Value of D-dimer testing for the exclusion of pulmonary embolism in patients with previous venous thromboembolism. Arch Intern Med. 2006Jan23;166(2):176-80. DOI: http://10.1001/archinte.166.2.176

  28. James AH. Thromboembolism in pregnancy: recurrence risks, prevention and management. Curr Opin Obstet Gynecol. 2008;20:550-6.

  29. Abenante A, Zuretti F, Dedionigi C, Tangianu F, Dentali F. D-dimer testing to assess the individual risk of venous thromboembolic recurrence in non-elderly patients of both genders: follow the rules! Intern Emerg Med. 2020 Apr;15(3):369-370. DOI: http://10.1007/s11739-019-02249-3

  30. Douma RA, Tan M, Schutgens REG, Bates SM, Perrier A, Legnani C, et al. Using an age- dependent D-dimer cut-off value increases the number of older patients in whom deep vein thrombosis can be safely excluded. Haematologica. 2012;97(10):1507-13.

  31. van Es N, van der Hulle T, van Es J, den Exter PL, Douma RA, Goekoop RJ, et al. Wells Rule and d-Dimer Testing to Rule Out Pulmonary Embolism: A Systematic Review and Individual-Patient Data Meta-analysis. Ann Intern Med. 2016 Aug;165(4):253-61. DOI: http://10.7326/M16-0031

  32. Hu W, Wang Y, Li J, Huang J, Pu Y, Jiang Y, et al. The Predictive Value of d-Dimer Test for Venous Thromboembolism During Puerperium: A Prospective Cohort Study. Clin Appl Thromb Hemost. 2020 Jan-Dec;26:1076029620901786.

  33. Chan WS, Lee A, Spencer FA, Chunilal S, Crowther M, Wu W, et al. D-dimer testing in pregnant patients: towards determining the next 'level' in the diagnosis of deep vein thrombosis. J Thromb Haemost. 2010May;8(5):1004-11. DOI: http://10.1111/j.1538-7836.2010.03783.x

  34. Palareti G, Cosmi B, Legnani C. D-dimer testing to determine the duration of anticoagulant therapy. Curr Opin Pulm Med, 2007; 13:393-7

  35. Kou HM, Zhang XP, Wang MZ, Deng J, Mei H, Hu Y. Diagnostic and Prognostic Value of Plasma Factor V Activity and Parameters in Thrombin Generation for Disseminated Intravascular Coagulation in Patients with Hematological Malignancies. Curr Med Sci. 2019 Aug;39(4):546-50. DOI: http://10.1007/s11596-019-2072-9

  36. Favresse J, Lippi G, Roy PM, Chatelain B, Jacqmin H, Ten Cate H, et al. D-dimer: Preanalytical, analytical, postanalytical variables, and clinical applications. Crit Rev Clin Lab Sci. 2018 Dec;55(8):548-77. DOI: http://10.1080/10408363.2018.1529734

  37. Macie C, Forbes L, Foster GA, Douketis JD. Dosing practices and risk factors for bleeding in patients receiving enoxaparin for the treatment of an acute coronary syndrome. Chest 2004;125:1616-21.

  38. Verhovsek M, Douketis JD, Yi Q, Shrivastava S, Tait RC, Baglin T, et al. Systematic review: D-dimer to predict recurrent disease after stopping anticoagulant therapy for unprovoked venous thromboembolism. Ann Intern Med. 2008 Oct;149(7):481-90, W94. DOI: http://10.7326/0003-4819-149-7-200810070-00008

  39. Latella J, Desmarais S. Relation between D-dimer level, venous valvular reflux and the development of post-thrombotic syndrome after deep vein thrombosis. J Thromb Haemost. 2010; 8(10): 2169-75

  40. Douketis J, Tosetto A, Marcucci M, Baglin T, Cushman M, Eichinger S, et al. Patient-level meta-analysis: effect of measurement timing, threshold, and patient age on ability of D-dimer testing to assess recurrence risk after unprovoked venous thromboembolism. Ann Intern Med. 2010 Oct;153(8):523-31. DOI: http://10.7326/0003-4819-153-8-201010190-00009

  41. Emmanuel A, Selvaraj D, Sen I, Agarwal S, Stephen E, Kota A, et al. D-dimer levels in patients with thromboangiitis obliterans. Natl Med J India. 2019 May-Jun;32(3):134-6. DOI: http://10.4103/0970-258X.278685

  42. Malaguarnera M, Latteri S, Bertino G, Madeddu R, Catania VE, Currò G, et al. D-dimer plasmatic levels as a marker for diagnosis and prognosis of hepatocellular carcinoma patients with portal vein thrombosis. Clin Exp Gastroenterol. 2018 Oct3;11:373-80. DOI: http://10.2147/CEG.S172663




2020     |     www.medigraphic.com