Table 2: Case reports and case series of cesarean section in MFS parturients performed with CSEA. |
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Author |
Dose and level |
Presence of MFS comorbidities |
Result |
Observations |
Ben Letaifa
|
CSEA at L3-L4 interspace. SD: hyperbaric Bup 5 mg + fentanyl 10 μg + morphine 150 μg. ED: (after 20 min of SD administration) lidocaine 2% 5 mL + fentanyl 10 μg (3 boluses with an interval of 5 min per catheter) |
Presence of aortic dissection with MV dysfunction |
Suitable blockage higher than T4 |
Preload with ringer lactate 500 mL. EV infusion of ephedrine 60 mg. SP: 100-150 mmHg. DP: 60-90 mmHg. HR: 100-120 bpm
|
Saeki |
CSEA at T12-L1 level. ED: none. SD: 2.2 mL 0.5% isobaric Bup |
MV regurgitation, aortic dissection |
Suitable blockage at T6 level |
Aortic dissection managed with medical treatment |
Baghirzada |
Case 1: epidural catheter at L3-L4. Spinal puncture at L4-L5 interspace. SD: 0.75% hyperbaric Bup 9 mg. ED: Bup 0.5% 150 mg Case 2: epidural catheter at L2-L3 level. SD: 0.75% hyperbaric Bup 13.5 mg + fentanyl 10 μg + morphine 100 μg |
Case 1: dilated aortic root (42 mm), MV prolapse, bicuspid AV, significant DE (lumbar dural sac area of 4.71 cm2), cervicothoracic scoliosis Case 2: moderate DE (lumbar dural sac area of 3.61 cm2), dilated aortic root (45 mm) |
Case 1: suitable block (ED anesthetic titrated during 15 min for reaching T4 level) Case 2: suitable block (bilateral T5 sensory level obtained after 15 min, catheter not used for anesthesia) |
Case 1: used NCOM. Baseline SP was maintained with phenylephrine EV boluses of 0.1 mg. Aortic root repairing surgery five days after CS Case 2: used NCOM |
Clayton |
Reported 7 cases managed with CSEA. Inadequate blocks received: SD: 0.5% hyperbaric Bup 2.8 mL (mean initial dose) (range 1.5-4 mL) + opioids |
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5 blocks were inadequate: 4 of the 5 CSEA parturients required additional measures despite having received ED |
Additional measures: 1 patient received general anesthesia, 1 repeated spinal, 2 EV opiates |
Heck (only CSEA cases) |
Case 1: ED: none. SD: Bup 17.5 mg + DM 300 μg Case 2: ED: 0.5% L-Bup 10 mL. SD: Bup 10 mg + DM 300 μg Case 3: SD: Bup 7.5 mg. ED: 0.5% Bup 5 mL Case 4: SD: Bup 12.5 mg + DM 300 μg. ED: 2% lidocaine 5 mL + 0.5% L-Bup 10 mL Case 5: SD: Bup 14 mg + DM 300 μg. ED: none Case 6: SD: Bup 17 mg + DM 300 μg. ED: 0.5% L-Bup 23 mL Case 7: SD: Bup 14 mg + DM 300 μg. ED: 0.5% L-Bup 10 mL + 2% lidocaine (plus adrenaline/ bicarbonate) 10 mL |
Case 1: aortic dilatation (42 mm) Case 5: aortic dilatation (59 mm) |
Case 1-2: adequate blocks Cases 3-7: inadequate blocks |
Case 4: converted to general anesthesia Case 7: repeated spinal anesthesia (0.5% Bup 1 mL) Cases 3 and 5-7: supplementary analgesia with alfentanil Cases 5-7: received nitrous oxide |
Sakurai |
ED (T12-L1 interspace): 10 mL normal saline + 2% lidocaine 10 mL per catheter (twice). SD (L3-L4 interspace): 0.5% hyperbaric Bup 11 mg + fentanyl 10 μg |
Aortic root dilatation (39 mm), DE, scoliosis |
Adequate sensory block at T11-T6 (beginning and end of surgery, respectively) |
4 mg ephedrine for one episode of hypotension. Hypesthesia and severe postdural puncture headache after CS |
Yang |
SD: 0.5% hyperbaric Bup 8 mg + 10 μg fentanyl. ED: 2% lidocaine 8 mL + 0.75% ropivacaine 8 mL per catheter (titrated over 20 min) |
Aortic regurgitation (repaired aortic root aneurysm during childhood) |
Adequate sensory block at T4 level |
SP above 100 mmHg (invasive) maintained with ephedrine 4 mg EV (twice) |
Coffman |
SD: 0.75% Bup 0.5 mL + fentanyl 15 μg + morphine 100 μg (L3-L4 interspace). ED: 2% lidocaine + 1:200,000 epinephrine 5 mL (4 doses) in 10 min (1st catheter). 2-chloroprocaine 5 mL (4 doses) in 10 min (2nd catheter, L2-L3 interspace) |
Aortic root replacement caused by aortic dissection one year before CS |
Failed block. converted to general anesthesia. CS performed in lateral decubitus position |
Monitored invasive pressure. Phenylephrine EV infusion (25-50 μg/min) + 20 μg of epinephrine (two episodes of hypotension) |
Naud |
Doses provided in CSEA not reported |
Dilated aortic root (49 mm), DE |
CS without complications. Patient was delivered in lateral decubitus position |
Valve-sparing aortic root repair on 5th day after CS |
MFS = Marfan syndrome; CSEA = combined spinal-epidural anesthesia; Bup = bupivacaine; min = minute; L-Bup = levobupivacaine; SD = subarachnoid dose; ED = epidural dose; MV = mitral valve; EV = endovenous; SP = systolic pressure; DP = diastolic pressure; HR = heart rate; DE = dural ectasia; AV = aortic valve; NCOM = noninvasive cardiac output monitor; CO = cardiac output; CS = cesarean section; DM = diamorphine. Source: built by authors with references(4-10,12,13). |