Stowell,

2009

680

10 to 13

Spine

surgery

EPO

(168,000 IU)

(n = 340)

Oral iron

(n = 340)

Preoperative

1. Deep vein thrombosis and other thrombovascular events

Weber,

2005

695

10-13

Elective

orthopedic

procedure

(spine, hip

and knee)

EPO

(168,000 IU)

(n = 460)

Oral iron

(n = 235)

1. Number of red blood cell transfusions

2. Hemoglobin

3. Thrombotic events

Wurnig,

2001

1. Number of red blood cell transfusions

2. Mortality

3. Thrombovascular events

4. Hemoglobin

5. Iron studies (serum ferritin, serum iron)

Feagan,

2000

201

9.8 to 13.7

Total hip

joint

replacement

EPO

(80,000 IU)

with oral iron

(n = 44)

Placebo

with oral iron

(n = 78)

Preoperative

1. Number of red blood cell transfusions

2. Reticulocyte count

3. Thrombovascular events

De

Andrade,

1996

290

< 15

Major o

rthopedic

surgery

EPO

(105,000 IU)

with oral iron

(n = 101)

EPO

(315,000 IU)

with oral iron

(n = 112)

Placebo

with oral iron

(n = 103)

Pre and

postoperative

1. Blood loss

2. Transfusions

3. Thrombovascular events

4. Adverse events (nausea, vomiting, pyrexia)

Faris,

1996

185

No haemoglobin criteria

Major

orthopedic

surgery

EPO

(105,000 IU)

with oral iron

(n = 71)

EPO

(315,000 IU)

with oral iron

(n = 69)

Placebo

with oral iron

(n = 10)

Pre- and

postoperative

1. Transfusion

2. Reticulocyte count

3. Hemoglobin

4. Chest pain

5. Depression