|
Table 2: Toxic effects of NETs on lung epithelium and epithelial cells. |
|
|
NET components |
Cytotoxic effect |
|
DNA fibers |
Diffuse alveolar damage and hemorrhage |
|
Histones |
Increase the permeability of the endothelium |
|
NE |
Destruction of the cytoskeleton of endothelial cells. Affects the integrity of the alveolar barrier. Associated with inflammation and thrombosis by the release of proinflammatory cytokines. |
|
MPO |
Involved in epithelial cell apoptosis by the release of ROS |
|
DNA = deoxyribonucleic acid. MPO = myeloperoxidase. NE = neutrophil elastase. NET = neutrophil extracellular traps. |
|