|
Table 5: Treatment of severe exacerbation. |
|||
|
Agent |
Selection |
Alternative |
Duration (days) |
|
Haemophilus influenzae |
Ceftriaxone 2 g/24 h IV |
Amoxicillin/clavulanate 500/125 mg 2 tab every 8 h PO |
14-21 |
|
Staphylococcus aureus |
Vancomycin 15-20 mg/kg/8 - 12 h IV |
Vancomycin 15-20 mg/kg/8-12 h IV |
14-21 |
|
MRS |
Linezolid 600 mg/12 h IV |
Vancomycin 15-20 mg/kg/8-12 h IV Ceftriaxone 600 mg every 12 h IV |
14-21 |
|
Pseudomonas |
Ceftazidime 2 g every 8 h IV + tobramycin 5-10 mg/kg every 24 h IV |
Imipenem 1 g every 8 h or piperacillin/tazobactam 4-8 g every 24 h or cefepime 2 g every 8 h or meropenem 2 g every 8 h or ciprofloxacin 400 mg every 12 h + amikacin 15-20 mg/kg every 24 h or gentamicin 5-7 mg/kg every 24 h |
14-21 |
|
MRS = Methicillin-resistant Staphylococcus aureus. PO = PER OS (orally). IV = intravenous. |
|||