Table 1: Receptors, genes and agonists of

specialized pro-resolving lipid mediators in various cells.

SPM

GPCR Receptors

Gen

Antagonist

Cells

RvD1

ALX, ALX/FPR2,

FPR2, DRV1,

GPCR32/ALX

GPCR32

–

PMN, DC, monocytes, macrophages, macrophages, epithelial cells, fibroblasts

RvD2

DRV2,

DRV/GPCR2,

DRV2/GPCR18,

GPCR18

–

–

NKs, PMNs, lymphocytes, monocytes, macrophages, epithelial cells

RvD3

ALX, DRV1

–

–

Lymphocytes, PMNs, monocytes, macrophages

RvD5

DRV1,

DRV1/GPCR32

GPCR32

–

PMN

AT-

RvD1

ALX/FPR2

–

–

NKs, PMNs, lymphocytes, monocytes, macrophages, epithelial cells

RvE1

ChemR23, ERV

CMKLR1

BLT1

PMN, monocytes, macrophages

RvE2

ERV1/ChemR23

CMKLR1

BLT1

Monocytes, macrophages

LXA4

ALX, FPR2

FPR2

CB1

NKs, PMNs, lymphocytes, monocytes, macrophages, epithelial cells

AT-

LXA4

ALX,

DRV1/GPCR32

GPCR32

–

NKs, PMNs, lymphocytes, monocytes, macrophages, epithelial cells

Mar1

–

–

BLT1

PMNs, lymphocytes, macrophages

SPM = specialized pro-resolving lipid mediators;

GPCR = G protein-coupled receptors;

RvD1 = resolvin D1;

ALX = lipoxin receptor;

FPR2 = N-formyl peptide receptor 2;

PMN = polymorphonuclear cells;

GPCR32 = G protein-coupled receptor 32;

DC = dendritic cells;

RvD2 = resolvin D2;

DRV2 = resolvin D2 receptor;

DRV = resolvin D-series resolvin receptor;

GPCR2 = G protein-coupled receptor 2;

GPCR18 = G protein-coupled receptor 18;

NK = natural killer cells;

RvD3 = resolvin D3;

DRV1 = resolvin D1 receptor;

RvD5 = resolvin D5;

AT-RvD1 = aspirin-triggered resolvin D1;

RvE1 = resolvin E1;

ERV = E-series resolvin receptor;

CMKLR1 = chemerin chemokine-like receptor 1;

RvE2 = resolvin E2;

ERV1 = resolvin E1 receptor;

LXA4 = lipoxin A4;

CB1 = cannabinoid receptor type 1;

AT-LXA4 = aspirin-triggered lipoxin A4;

Mar1 = maresin 1.