Edad (años)*

57 [47-67]

54.5 [12.9]

63.4 [13.3]

< 0.001

IMC*

28.7 [26.2-32.0]

28.4 [26.4-32.0]

29.6 [25.3-32.5]

0.908

Días piso (n = 432)*

2 [0-5]

2 [0-5]

3 [0-6]

0.303

Días UCI (n = 455)*

13 [9-21]

13 [9-19]

17 [11-27]

< 0.001

Días piso 2 (n = 432)*

5 [0-9]

7 [4-10]

0 [0-0]

< 0.001

Días totales (n = 455)*

23 [16-32]

23 [18-31]

22 [15-33]

0.248

Ingreso a UTI (n = 455)

451 (98)

298 (73)

110 (27)

0.391

Días con intubación (n = 410)*

10 [6-16]

9 [6-14]

15 [9-24.8]

< 0.001

Días de reintubación (n = 21)*

17 [5-22]

1 [0-6]

0 [0-11]

0.478

Diagnóstico de ingreso (n = 416)

NAC

292 (70)

218 (52)

74 (18)

0.368

NAC + SIRA grave

112 (27)

77 (19)

35 (8)

IVRS

8 (2)

5 (1)

3 (1)

SIRA

2 (0.5)

1 (0.25)

1 (0.25)

NAC + SIRA + estado postparo

1 (0.25)

1 (0.25)

0 (0.0)

Neumonía intrahospitalaria + SIRA

1 (0.25)

0 (0.0)

1 (0.25)

Comorbilidades

LRA

104 (23)

56 (60)

37 (40)

0.002

IAM

18 (4)

8 (53)

7 (47)

0.079

TEP

12 (3)

6 (50)

6 (50)

0.067

EVC

3 (0.7)

1 (50)

1 (50)

0.120

Síntomas

Fiebre

319 (70)

217 (75)

74 (25)

0.184

Disnea

297 (65)

204 (74)

73 (26)

0.526

Tos

263 (58)

178 (72)

69 (28)

0.715

Cefalea

148 (33)

110 (79)

29 (21)

0.034

Dolor faríngeo

111 (24)

77 (75)

25 (25)

0.471

Diarrea

64 (14)

42 (71)

17 (29)

0.758

Rinorrea

52 (11)

34 (71)

14 (29)

0.754

Escala de Glasgow*

15 [15-15]

15 [15-15]

15 [15-15]

0.999

Laboratoriales basales

Linfocitos (× 103 cel/mm3)*

0.7 [0.5-1.0]

0.7 [0.5-1.0]

0.6 [0.4-1.1]

0.211

Leucocitos (× 103 cel/mm3)*

9.5 [6.2-13.6]

9.3 [6.0-13.6]

9.1 [6.0-12.3]

0.641

IL-6 (pg/mL)*

75.0 [50.4-141.0]

75 [49.6-388.0]

99.6 [85.5-116.0]

0.825

Dímero D (μg/mL)*

740 [450-1,310]

680 [445-1,115]

1,085 [483-2,888]

< 0.001

LDH (U/L)*

343 [267-441]

343 [283-427]

343 [250-532]

0.774

PCR (mg/L)*

139 [62-216]

141.0 [61.0-219.0]

130.0 [64.3-199.0]

0.704

Procalcitonina (ng/mL)*

0.244 [0.130-0.488]

0.213 [0.119-0.425]

0.375 [0.211-0.730]

0.002

Ferritina (ng/mL)*

722 [364-1,255]

765 [354-1,281]

623 [394-1,185]

0.689

PaFi arterial*

115 [70-216]

126.0 [72.6-227.0]

104.0 [64.4-180.0]

0.130

PO2 (mmHg)*

67.7 [56.2-86.2]

67.4 [56.3-84.0]

71.9 [55.4-91.2]

0.309

PCO2 (mmHg)*

30.1 [26.6-34.4]

29.9 [26.5-33.8]

30.2 [27.1-34.0]

0.688

Lactato (mmol/L)*

1.5 [1.1-2.0]

1.4 [1.0-2.0]

1.6 [1.20-2.15]

0.188

HCO3 (mmol/L)*

21.4 [19.0-23.5]

21.4 [19.4-23.2]

21.2 [18.3-23.4]

0.351

BNP*

87.2 [29.9-192.0]

61.2 [28.4-137.0]

192.0 [19.2-288.0]

0.601

Troponina I (ng/mL)*

16.0 [8.2-44.3]

15.0 [9.9-42.6]

21.7 [14.7-41.5]

0.535

Laboratoriales (UTI)

Leucocitos (× 103 cel/mm3)*

10.9 [7.3-14.4]

10.9 [7.2-14.1]

10.7 [7.3-14.0]

0.934

IL-6 (pg/mL)*

106 [39.2-739.0]

174 [13.7-513.0]

1,123 [103-2,210]

0.188

Dímero D (μg/mL)*

1,020 [620-2,323]

880 [600-1,463]

1,750 [810-4,890]

< 0.001

LDH (U/L)*

374 [285-479]

367 [286-443]

375 [275-543]

0.626

PCR (mg/L)*

152 [62-229]

161 [56.2-235.0]

145 [76.9-208.0]

0.727

Procalcitonina (ng/mL)*

0.310 [0.140-0.700]

0.244 [0.110-0.465]

0.390 [0.213-1.140]

0.011

Ferritina (ng/mL)*

966 [470-1,405]

939 [473-1,429]

990 [453-1,285]

0.843

PaFi arterial*

88.2 [62.3-144.0]

96.6 [65.8-152.0]

77.0 [58.5-122.0]

0.013

PO2 (mmHg)*

68.3 [55.7-82.1]

69.2 [56.3-83.8]

65.8 [55.2-78.6]

0.160

PCO2 (mmHg)*

34.0 [28.9-41.0]

34.0 [28.9-41.0]

34.0 [25.8-41.1]

0.936

Lactato (mmol/L)*

1.6 [1.1-2.1]

1.5 [1.1-2.0]

1.8 [1.3-2.3]

0.017

HCO3 (mmol/L)*

22.5 [20.1-25.3]

22.6 [20.3-25.3]

22.0 [19.1-24.9]

0.331

BNP*

112.0 [45.7-382.0]

68.6 [26.6-173.0]

192.0 [83.0-396.0]

0.023

Troponina I (ng/mL)*

33.3 [15.0-180.0]

19.9 [12.8-164.0]

31.1 [23.5-228.0]

0.682

Laboratoriales finales

Linfocitos (× 103 cel/mm3)*

1.3 [0.8-1.8]

1.4 [1.0-1.9]

0.8 [0.4-1.2]

< 0.001

Leucocitos (× 103 cel/mm3)*

8.3 [6.0-11.1]

7.4 [5.7-9.6]

14.6 [9.2-20.1]

< 0.001

IL-6 (pg/mL)*

85.1 [45.5-89.2]

45.5 [25.7-65.3]

93.2 [93.2-93.2]

0.667

Dímero D (μg/mL)*

1,730 [840-3,210]

1,710 [890-2,660]

6,305[675-12,685]

0.284

LDH (U/L)*

244 [210-345]

228 [190-285]

432 [381-699]

< 0.001

PCR (mg/L)*

13.4 [4.6-50.1]

9.84 [2.95-32.7]

119 [56.9-183.0]

< 0.001

Procalcitonina (ng/mL)*

0.0960 [0.0645-0.396]

0.08 [0.05-0.15]

2.6 [0.716-7.960]

< 0.001

Ferritina (ng/mL)*

495 [298-728]

495 [315-702]

537 [272-987]

0.770

PaFi arterial*

91.0 [56.5-170.0]

130.0 [93.0-213.0]

67.8 [53.0-105.0]

< 0.001

PO2 (mmHg)*

61.7 [48.1-78.2]

62.8 [48.0-77.3]

59.4 [48.5-78.7]

0.954

PCO2 (mmHg)*

46.3 [39.7-59.5]

42.3 [36.5-47.8]

50.1 [40.9-67.4]

0.002

Lactato (mmol/L)*

1.7 [1.1-3.1]

1.40 [1.10-2.15]

2.20 [1.30-5.70]

0.006

HCO3 (mmol/L)*

27.2 [21.8-30.6]

26.9 [22.6-30.6]

27.0 [21.4-30.8]

0.925

BNP*

178 [41.5-867.0]

42.5 [28.2-88.6]

625 [213-1,513]

< 0.001

Troponina I (ng/mL)*

69.1 [13.0-411.0]

21.7 [17.2-26.2]

186 [83.0-411.0]

0.533

TAC de tórax (n = 418)

CO-RADS 1

2 (0.5)

2 (0.5)

0 (0.0)

0.014

CO-RADS 2

2 (0.5)

0 (0.0)

2 (0.5)

CO-RADS 3

2 (0.5)

0 (0.0)

2 (0.5)

CO-RADS 4

6 (1.5)

4 (1.0)

2 (0.5)

CO-RADS 5

53 (13.0)

34 (8.0)

19 (4.0)

CO-RADS 6

353 (84.0)

264 (64.0)

89 (21.0)

Frecuencia cardiaca (lpm)

98 [87-111]

98 [87-111]

98 [85-112]

0.758

Frecuencia respiratoria (rpm)

24 [20-30]

24 [20-30]

24 [20-31]

0.500

Tensión arterial sistólica (mmHg)*

128 [117-142]

127 [117-141]

130 [120-145]

0.277

Tensión arterial diastólica (mmHg)*

75 [66-83]

74 [67-83]

76 [64-82]

0.908

Temperatura (oC)*

37 [36.6-37.6]

37.0 [36.6-37.6]

37.7 [36.5-37.6]

0.999

Saturación de O2 (%)*

85 [77-90]

86 [77-90]

83 [74-90]

0.072

Posición prono (n = 419)

332 (79)

242 (73)

89 (27)

0.731

Prono temprano (n = 332)*

243 (73)

182 (75)

62 (25)

0.310

Tiempo de prono en días (n = 332)*

3 [3-4]

3 [3-4]

4 [2-5]

0.414

Complicaciones por la posición prono (n = 322)

Sin complicación

299 (93)

226 (70)

73 (23)

< 0.001

Inestabilidad

14 (4.0)

6 (2.0)

8 (2.3)

Úlceras por presión

5 (2.0)

4 (1.2)

1 (0.3)

Disfunción del tubo

1 (0.3)

0 (0.0)

1 (0.3)

Extubación espontánea

1 (0.3)

1 (0.3)

0 (0.0)

Fuga + cambio de tubo

1 (0.3)

0 (0.0)

1 (0.3)

Vómito

1 (0.3)

0 (0.0)

1 (0.3)

Dispositivos utilizados de O2 (n = 419)

PAF

236 (56)

165 (40)

70 (17)

0.326

MR

166 (40)

126 (30)

40 (9.4)

VMNI

13 (3)

10 (2)

3 (0.7)

PN

4 (1)

3 (0.7)

1 (0.2)

Uso de esteroide sistémico (n = 419)

373 (89)

266 (72)

106 (28)

0.111

Presencia de SIRA (n = 419)

417 (99.5)

303 (73)

113 (27)

0.469

Presencia de choque (n = 419)

398 (95)

284 (72)

113 (28)

0.017

Presencia de NIH (n = 419)

158 (38)

91 (58)

67 (42)

< 0.001

Presencia de LRA (n = 419)

198 (47.3)

108 (55)

90 (45)

< 0.001

Uso de TRR (n = 418)

53 (13)

17 (32)

36 (68)

< 0.001

Defunción intrahospitalaria (n = 418)

114 (27)

0 (0)

114 (27)

—

Desenlace (n = 418)

Alta a domicilio por mejoría

280 (67)

280 (67)

0 (0)

—

Defunción

114 (27)

0 (0)

114 (27)

Alta voluntaria

22 (5)

22 (27)

0 (0)

Alta por traslado

2 (1)

2 (1)

0 (0)

Seguimiento a 30 días (n = 417)

Alta a domicilio por mejoría

161 (39)

161 (40)

0 (0)

—

Pérdida del seguimiento

139 (33)

139 (33)

0 (0)