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Tabla 4: Riesgo de mortalidad de los marcadores inflamatorios elevados en solitario y en conjunto con mayor disfunción orgánica. |
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Covariable |
HR |
IC 95% |
p |
|
PCR ≥ 16 mg/mL |
1.3 |
1.1-1.8 |
0.02 |
|
PCT ≥ 0.83 ng/mL |
2.5 |
1.3-4.9 |
< 0.001 |
|
DD ≥ 1,290 ng/mL |
1.5 |
0.8-2.8 |
0.13 |
|
FS ≥ 1,450 ng/mL |
0.6 |
0.3-1.3 |
0.25 |
|
IL6 ≥ 197 pg/mL |
1.3 |
0.7-1.5 |
0.38 |
|
≤ 2 MI altos |
0.9 |
0.5-1.7 |
0.98 |
|
≥ 3 MI altos |
1.1 |
0.6-2.2 |
0.60 |
|
SOFA ≥ 10 pts. |
0.9 |
0.4-2.2 |
0.90 |
|
APACHE-II ≥ 25 pts. |
1.5 |
0.66-3.3 |
0.32 |
|
SAPS-II ≥ 50 pts. |
1.8 |
0.6-2.6 |
0.47 |
|
PaO2/FiO2 < 150 mmHg |
1.80 |
0.9-3.7 |
0.08 |
|
PaCO2 > 50 mmHg |
0.80 |
0.4-1.7 |
0.66 |
|
Crs’ < 30 mL/cmH2O |
2.30 |
1.2-4.3 |
0.01 |
|
PCR ≥ 16 mg/mL + SOFA ≥ 10 pts. |
1.40 |
0.7-3.0 |
0.28 |
|
PCR ≥ 16 mg/mL + APACHE-II ≥ 25 pts. |
0.9 |
0.3-2.5 |
0.91 |
|
PCR ≥ 16 mg/mL + SAPS-II ≥ 50 pts. |
0.81 |
0.3-1.8 |
0.62 |
|
PCR ≥ 16 mg/mL + PaO2/FiO2 ≤ 150 mmHg |
0.86 |
0.4-1.6 |
0.65 |
|
PCR ≥ 16 mg/mL + PaCO2 > 50 mmHg |
1.38 |
0.7-2.7 |
0.35 |
|
PCR ≥ 16 mg/mL + Crs’ < 30 mL/cmH2O |
1.65 |
0.8-3.3 |
0.15 |
|
PCT ≥ 0.83 ng/mL + SOFA ≥ 10 pts. |
1.5 |
0.7-3.0 |
0.24 |
|
PCT ≥ 0.83 ng/mL + APACHE-II ≥ 25 pts. |
1.8 |
0.8-4.0 |
0.15 |
|
PCT ≥ 0.83 ng/mL + SAPS-II ≥ 50 pts. |
1.4 |
0.7-2.8 |
0.30 |
|
PCT ≥ 0.83 ng/mL + PaO2/FiO2 ≤ 150 mmHg |
1.87 |
1.0-3.3 |
0.32 |
|
PCT ≥ 0.83 ng/mL + PaCO2 > 50 mmHg |
2.2 |
1.1-4.4 |
0.02 |
|
PCT ≥ 0.83 ng/mL + Crs’ < 30 mL/cmH2O |
2.95 |
1.5-5.5 |
< 0.001 |
|
DD ≥ 1,290 ng/mL + SOFA ≥ 10 pts. |
1.52 |
0.5-4.3 |
0.42 |
|
DD ≥ 1,290 ng/mL + APACHE-II ≥ 25 pts. |
0.68 |
0.1-2.7 |
0.59 |
|
DD ≥ 1,290 ng/mL + SAPS-II ≥ 50 pts. |
0.84 |
0.3-2.2 |
0.73 |
|
DD ≥ 1,290 ng/mL + PaO2/FiO2 ≤ 150 mmHg |
1.18 |
0.5-2.4 |
0.65 |
|
DD ≥ 1,290 ng/mL + PaCO2 > 50 mmHg |
1.0 |
0.4-2.4 |
0.93 |
|
DD ≥ 1,290 ng/mL + Crs’ < 30 mL/cmH2O |
2.49 |
1.1-5.4 |
0.02 |
|
FS ≥ 1,450 ng/mL + SOFA ≥ 10 pts. |
1.44 |
0.4-5.1 |
0.52 |
|
FS ≥ 1,450 ng/mL + APACHE-II ≥ 25 pts. |
1.92 |
0.6-5.7 |
0.23 |
|
FS ≥ 1,450 ng/mL + SAPS-II ≥ 50 pts. |
0.8 |
0.1-3.5 |
0.77 |
|
FS ≥ 1,450 ng/mL + PaO2/FiO2 ≤ 150 mmHg |
1.0 |
0.53-2.1 |
0.84 |
|
FS ≥ 1,450 ng/mL + PaCO2 > 50 mmHg |
0.84 |
0.5-1.9 |
0.70 |
|
FS ≥ 1,450 ng/mL + Crs’ < 30 mL/cmH2O |
1.19 |
0.5-2.7 |
0.64 |
|
IL6 ≥ 197 pg/mL + SOFA ≥ 10 pts. |
0.61 |
0.3-1.2 |
0.14 |
|
IL6 ≥ 197 pg/mL + APACHE-II ≥ 25 pts. |
1.28 |
0.5-3.3 |
0.60 |
|
IL6 ≥ 197 pg/mL + SAPS-II ≥ 50 pts. |
0.96 |
0.4-2.2 |
0.93 |
|
IL6 ≥ 197 pg/mL + PaO2/FiO2 ≤ 150 mmHg |
1.74 |
0.7-4.1 |
0.20 |
|
IL6 ≥ 197 pg/mL + PaCO2 > 50 mmHg |
0.48 |
0.3-1.9 |
0.69 |
|
IL6 ≥ 197 pg/mL + Crs’ < 30 mL/cmH2O |
3.1 |
1.1-4.9 |
0.03 |
|
≤ 2 MI altos + SOFA ≥ 10 pts. |
0.36 |
0.2-1.1 |
0.81 |
|
≤ 2 MI altos + APACHE-II ≥ 25 pts. |
1.35 |
0.3-5.3 |
0.66 |
|
≤ 2 MI altos + SAPS-II ≥ 50 pts. |
1.73 |
0.6-4.9 |
0.30 |
|
≤ 2 MI altos + PaO2/FiO2 ≤ 150 mmHg |
1.96 |
0.9-3.9 |
0.63 |
|
≤ 2 MI altos + PaCO2 > 50 mmHg |
0.58 |
0.2-1.4 |
0.23 |
|
≤ 2 MI altos + Crs’ < 30 mL/cmH2O |
1.0 |
0.4-2.4 |
0.85 |
|
≥ 3 MI altos + SOFA ≥ 10 pts. |
1.77 |
0.6-4.6 |
0.23 |
|
≥ 3 MI altos + APACHE-II ≥ 25 pts. |
1.3 |
0.4-3.6 |
0.60 |
|
≥ 3 MI altos + SAPS-II ≥ 50 pts. |
0.7 |
0.3-1.8 |
0.52 |
|
≥ 3 MI altos + PaO2/FiO2 < 150 mmHg |
0.70 |
0.3-1.5 |
0.38 |
|
≥ 3 MI altos + PaCO2 > 50 mmHg |
1.20 |
0.5-2.8 |
0.53 |
|
≥ 3 MI altos + Crs’ < 30 mL/cmH2O |
2.00 |
1.0-4.2 |
0.06 |
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HR = cociente de riesgo. IC 95% = intervalo de confianza de 95%. PCR = proteína C reactiva. PCT = procalcitonina. DD = dímero D. FS = ferritina. IL6 = interleucina-6. MI = marcadores inflamatorios. SOFA = sequential organ failure assessment. APACHE-II = Acute Physiology and Chronic Health Evaluation II. SAPS-II = Simplified Acute Physiology Score II. |
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