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Table 1: Five morphogenic phases of fat formation. |
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Stages |
Events |
Characteristics |
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1 |
Undifferentiated fat tissue condensation without |
Fat is composed of an amorphous ground substance and fibers are organized into loose connective tissue; mesenchymal cells aggregate |
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2 |
Vascular invasion / angiogenesis |
Primitive blood vessels proliferate (emergence of the characteristic fat tissue) |
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A rich capillary network develops from each small blood vessel |
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Surrounding mesenchymal cells differentiate into stellate preadipocytes |
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Blood vessels signal areas where fat cells Will organize into groups |
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3 |
Development of mesenchymal lobules |
These lobules contain stellate mesenchymal cells or pre-adipocytes without lipid droplets |
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4 |
Appearance of primitive fat tissue lobules |
Fat storage becomes visible |
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5 |
Definitive fat tissue lobules |
Fat lobules are well separated from each other through connective tissue septa |
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Taken and adaptaded from: Poissonnet CM et al.9 |
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