Table 1: Reported cases of infective endocarditis due to Streptococcus gordonii.

Author

Country

Pt.

no.

Year

Age/gender

Symptoms

(time)

Valve

Embolism

Diagnostic

modality

Vegetation

(valve/number/size)

Aneurysm

(valve)

Perforation

(valve)

AR

MR

Antibiotic

treatment

(duration)

Surgery

Outcome

Tomsic

et al.6

United States

1

2016

48/M

Fever, fatigue,

cough

(2 months)

Bicuspid

AV, MV

Yes

TTE,

TEE

AV/1/< 10 mm,

MV/NR/NR

Yes

(NCC AV,

anterior MVL)

Yes

(anterior MVL)

Severe

Severe

IV penicilin

(6 wk), IV

gentamicin

(2 wk)

AVR,

MVR

Cure

Baca

et al.7

Peru

2

2017

58/M

Fever, vomiting,

low back pain

(2 months)

AV, MV

Yes

TEE

AV/multiples/9 mm,

MV/NR/NR

Yes

(anterior MVL)

Yes

(NCC AV)

Severe

Severe

NR

AVR,

MVR

NR

Dadon

et al.14

Israel

3

1998

23/F

Fever (NR)

MV

NR

TEE

NR

NR

NR

NR

NR

IV gentamicin

(2 wk)

None

Cure

4

2006

37/M

Dyspnea (NR)

AV

NR

TTE

NR

NR

NR

NR

NR

NR

AVR

Died

5

2006

45/M

Fever (NR)

MV

NR

TEE

NR

NR

NR

NR

NR

IV penicilin

(6 wk),

gentamicin

(1 wk)

MVR

Cure

6

2007

75/M

Fever (NR)

MV, AV

NR

TEE

NR

NR

NR

NR

NR

IV penicilin

(6 wk)

No

Cure

7

2013

83/F

Fever (NR)

MV

NR

TEE

NR

NR

NR

NR

NR

IV ceftriaxone

(6 wk)

No

Cure

8

2014

78/M

Fever (NR)

MV, AV

NR

TEE

NR

NR

NR

NR

NR

IV penicilin

(6 wk)

AVR,

MVR

Cure

9

2014

71/M

Fever (NR)

NR

NR

TEE

NR

NR

NR

NR

NR

IV penicilin

(6 wk)

No

Cure

10

2015

31/M

Fever (NR)

MV

NR

TTE

NR

NR

NR

NR

NR

IV penicilin

(4 wk)

MVR

Cure

11

2016

82/M

Low back pain

(2 wk)

MV

Yes

TEE

MV/1/14 mm

None

None

None

None

IV penicilin

(8 wk)

None

Cure

12

2016

63/M

Fever,

low back pain

(2 wk)

AV

Yes

TEE

AV/1/13 mm

None

None

None

None

IV penicilin

(8 wk), IV

gentamicin

(2 wk), oral amoxycyline

(4 wk)

None

Cure

13

2017

71/M

General

deterioration

(NR)

AV

NR

TEE

NR

NR

NR

NR

NR

IV penicilin

(6 wk)

AVR,

MVR

Cure

Callejo-Goena

et al.15

Spain

14

2018

60/M

Fever

(2 wk)

MV

Yes

TEE

MV/1/NR

None

None

None

Severe

Ceftriaxone

(3 months)

None

Cure

Mosailova

et al.1

United States

15

2019

31/M

Bilateral lower

extremity edema

(2 days)

MV

Yes

TTE

MV/1/NR

None

None

None

Severe

IV ceftriaxone

(6 wk)

MVR

NR

Komorovsky

et al.16

Ukraine

16

2019

11/F

Fever,

weakness,

joint pain

(NR)

MV

None

NR

MV/1/6 mm

None

None

None

Moderate

NR

MV

annuloplasty

Cure

Peechakara

et al.17

India

17

2019

42/M

Fever,

back pain,

hemoptysis,

joint pain

(3 months)

AV, MV

None

TTE,

TEE

AV/NR/NR

None

Yes

(anterior MVL)

Moderate

NR

IV ceftriaxone

(6 wk), IV gentamicin

(2 wk)

None

NR

Quan Li

et al.18

China

18

2020

36/M

Fever

(2 months)

Bicuspid

AV

None

TTE,

TEE

AV/ NR/NR

None

None

Severe

NR

NR

AVR

Cure

Yue Wang

et al.19

China

19

2020

39/F

Fever, headache

(6 months)

MV

Yes

TEE

MV/multiples/NR

None

None

None

None

IV vancomycin

(12 days)

None

Died

Bridwell

et al.20

United States

20

2020

63/M

Fever

(3 wk)

MV

None

TEE

MV/NR/NR

None

None

None

NR

IV gentamicin

(2 wk),

IV penicilin

(4 wk)

None

Cure

Arbune

et al.21

Romania

21

2021

23/F

Fever, malaise

(9 wk)

AV

None

TTE

AV/1/5 mm

None

None

NR

NR

IV ceftriaxone

(6 wk)

None

Cure

Jiménez Melo

et al.22

Spain

22

2021

76/F

Dyspnea

(4 months)

Mechanical

MV and AV

Yes

TEE,

FDG-PET /

CT

MV/2/7 mm,

AV/1/NR

None

None

None

None

IV ceftriaxone

(NR)

None

NR

Chang

et al.4

Malaysia

23

2021

28/M

Fever (1 wk),

abdominal pain

(3 days)

Bicuspid

AV, MV

Yes

TTE

AV/2/11 × 6 mm,

16 × 8 mm,

MV/1/5 × 8 mm

None

None

Severe

Moderate

IV penicilin

(6 wk)

NR

NR

Lim

et al.23

Malaysia

24

2022

40/M

Fever

(1 month)

PV

Yes

TTE,

CT

PV/1/23 × 12 mm

None

None

None

None

IV penicilin

(6 wk)

PVR

Cure

Chawla

et al.24

United States

25

2023

27/F

Sudden

loss of vision,

Severe headache

(4 days)

MV

Yes

TEE

MV/NR/NR

None

None

None

NR

IV ceftriaxone

(6 wk)

None

Cure

Qu Yi-Fan

et al.25

China

26

2023

61/M

Fever, malaise

(4 wk)

Bicuspid

AV

Yes

TEE

None

None

Yes

(AV)

Moderate-severe

Mild

NR

AVR, AV

valvuloplasty

Cure

Alanís-Naranjo

et al.

(present case)

Mexico

27

2023

60/M

Fever,

weight loss

(3 wk)

AV, MV

None

TEE

MV/1/11 × 5 mm

Yes

(anterior MVL)

Yes

(NCC AV,

anterior MVL)

Severe

Moderate

IV ceftriaxone

(1 month)

AVR,

MVR

Died

AR = aortic regurgitation.

AV = aortic valve.

AVR = aortic valve replacement.

CT = computed tomography.

F = female.

FDG-PET/CT = F-fluorodeoxyglucose positron emission tomography/computed tomography.

IV = intravenous.

M = male.

MR = mitral regurgitation.

MV = mitral valve.

MVL = mitral valve leaflet.

MVR = mitral valve replacement.

NCC = noncoronary cusp.

NR = not reported.

Pt = patient.

PV = pulmonary valve.

PVR = pulmonary valve replacement.

TEE = trans-esophageal echocardiogram.

TTE = trans-thoracic echocardiogram.