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Tabla 1: Estudios sobre inmunoterapia intralinfática empleando extractos de alérgenos. |
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Título del estudio y año |
Tipo de estudio |
Extracto alergénico |
Padecimiento alérgico |
Grupo etario (n) |
|
Intralymphatic immunotherapy with tyrosine-adsorbed allergens: a double-blind, placebo-controlled trial (2021)46 |
Ensayo clínico |
DPT, DF, gato, perro (o sus mezclas) absorbidos con L-tirosina |
Rinitis alérgica |
Adultos (32) |
|
Intralymphatic immunotherapy improves grass pollen allergic rhinoconjunctivitis: a 3-year randomized placebo-controlled trial (2021)47 |
Ensayo clínico |
Phleum pratense |
Rinoconjuntivitis alérgica |
Adultos (36) |
|
Intralymphatic immunotherapy for mountain cedar pollinosis: a randomized, double-blind, placebo-controlled trial (2020)48 |
Ensayo clínico |
Juniperus ashei |
Rinitis alérgica, rinoconjuntivitis alérgica |
Adultos (21) |
|
Sustained effects of intralymphatic pollen-specific immunotherapy on Japanese cedar pollinosis (2020)49 |
Ensayo clínico |
Cryptomeria japonica |
Rinitis alérgica |
Adultos (18) |
|
Intralymphatic immunotherapy in pollen-allergic young adults with rhinoconjunctivitis and mild asthma: a randomized trial (2020)50 |
Ensayo clínico |
Betula verrucosa y Phleum pratense |
Asma, rinoconjuntivitis alérgica |
Adolescentes y adultos (30) |
|
Clinical efficacy and safety of cervical intralymphatic immunotherapy for house dust mite allergic rhinitis: a pilot study (2019)37 |
Estudio de cohorte |
Ácaros |
Rinitis alérgica |
Adultos (81) |
|
Intralymphatic immunotherapy with 2 concomitant allergens, birch and grass: a randomized, double-blind, placebo-controlled trial (2018)51 |
Ensayo clínico |
Betula verrucosa y mezcla de 5 pastos (Phleum pratense, Dactylis glomerata, Lolium perenne, Poa pretense, Festuca pratense) |
Rinitis alérgica |
Adultos (60) |
|
Intralymphatic allergen immunotherapy against pollen allergy: a 3-year open follow-up study of 10 patients (2018)52 |
Ensayo clínico |
Betula verrucosa y mezcla de 5 pastos (Phleum pratense, Dactylis glomerata, Lolium perenne, Poa pretense, Festuca pratense) |
Rinoconjuntivitis alérgica |
Adultos (10) |
|
Intralymphatic immunotherapy of pollen induced rhinoconjunctivitis: a double-blind placebo-controlled trial (2016)53 |
Ensayo clínico |
Betula verrucosa y mezcla de 5 pastos (Phleum pratense, Dactylis glomerata, Lolium perenne, Poa pretense, Festuca pratense), ambos absorbidos con hidróxido de aluminio |
Rinoconjuntivitis alérgica |
Adultos (36) |
|
Intralymphatic immunotherapy induces allergen specific plasmablasts and increases tolerance to skin prick testing in a pilot study (2016)54 |
Estudio piloto abierto |
Phleum pratense |
Rinoconjuntivitis alérgica |
Adultos (7) |
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ITIL is a similarly effective treatment of grass pollen induced rhinitis for patients with moderate/severe and mild symptoms (2016)55 |
Ensayo clínico |
Phleum pratense |
Rinitis alérgica |
Adultos (36) |
|
Three-injection intralymphatic immunotherapy in adolescents and young adults with grass pollen rhinoconjunctivitis (2016)56 |
Ensayo clínico |
Phleum pratense absorbido con hidróxido de aluminio |
Rinoconjuntivitis alérgica |
Adolescentes y adultos (15) |
|
Intralymphatic allergen-specific immunotherapy: an effective and safe alternative treatment route for pollen-induced allergic rhinitis (2013)30 |
Estudio piloto abierto |
Betula verrucosa y mezcla de 5 pastos (Phleum pratense, Dactylis glomerata, Lolium perenne, Poa pretense, Festuca pratense) absorbidos con hidróxido de aluminio |
Rinitis alérgica |
Adultos (15) |
|
Is intralymphatic immunotherapy ready for clinical use in patients with grass pollen allergy? (2013)42 |
Ensayo clínico |
Phleum pratense absorbido con hidróxido de aluminio |
Rinoconjuntivitis alérgica |
Adultos (43) |
|
Intralymphatic immunotherapy for cat allergy induces tolerance after only 3 injections (2012)28 |
Ensayo clínico |
Proteína de fusión recombinante, no glucosidada MAT-Fel d 1 absorbida con hidróxido de aluminio |
Rinitis alérgica, rinoconjuntivitis alérgica |
Adultos (20) |
|
Intralymphatic allergen administration renders specific immunotherapy faster and safer: A randomized controlled trial (2008)6 |
Ensayo clínico |
Polen de Phleum pratense absorbido con hidróxido de aluminio |
Asma, rinitis alérgica, rinoconjuntivitis alérgica |
Adultos (112) |