Tabla 2: Moléculas en investigación para el tratamiento del carcinoma de mama triple negativo. |
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Molécula |
Diana |
Combinación |
Fase |
Identificador de ensayo clínico |
PVX410 |
Vacuna |
Cisplatino |
I/II |
NCT03362060 |
S 81694 |
TTK |
Paclitaxel |
I/II |
NCT03411161 |
Gedatolisb |
PI3K/AKT/m-TOR |
Talazoparib |
I |
NCT03911973 |
Abemaciclib |
CDK4,6 |
|
II |
NCT03130439 |
MLN0128 y MLN8237 |
TORC 1,2 |
|
I |
NCT02719691 |
|
Aurora A |
|
|
|
Icotinib |
EGFR |
|
II |
NCT02362230 |
Dinaciclib |
CDK 1,2,5,9 |
Pembrolizumab |
Ib |
NCT01676753 |
Galunisertib |
TGF-β |
Paclitaxel |
I |
NCT02672475 |
Bemcentinib |
AXL kinase |
Pembrolizumab |
II |
NCT03184558 |
M7824 |
TGF-β |
Eribulin |
I |
NCT03579472 |
Binimetinib |
MEK 1,2 |
Pembrolizumab |
I/II |
NCT03106415 |
Enobosarm |
Receptor de andrógenos |
Pembrolizumab |
II |
NCT02971761 |
L-NMMA |
i-NOS |
Docetaxel |
I/II |
NCT02834403 |
SGN-LIV1A |
Transportador de Zinc |
Pembrolizumab |
I/II |
NCT03310957 |
Onalespib |
Hsp 90 |
Paclitaxel |
I |
NCT02474173 |
Decitabin |
DNA metiltransferasa |
Carboplatin |
II |
NCT03295552 |
AZD8186 |
PI3Kβ |
Docetaxel |
I |
NCT03218826 |
Talazoparib |
PARPi |
Sacituzumab govitecan |
I/II |
NCT04039230 |
Inmunoféresis LW-02 |
sTNF-R |
Paclitaxel + carboplatino |
I/II |
NCT04004910 |
PMD-026 |
RSK1-4 |
|
I/Ib |
NCT04115306 |
Camrelizumab |
PD-1 |
NAB-Paclitaxel + famitinib |
II |
NCT04129996 |
LN-145 |
Linfocitos infiltrantes de tumor |
|
II |
NCT04111510 |
Ipasertib |
AKT |
Atezolizumab + NAB-Paclitaxel |
III |
NCT04177108 |
Binimetinib |
ERK, CDK 4/6 |
Palbociclib |
I/II |
NCT04494958 |
Ipatasertib |
PI3k/AKT/mTOR |
Quimioterapia |
IIa |
NCT04464174 |
TTAC-0001 |
VGFR2 |
Pembrolizumab |
Ib |
NCT03720431 |
HX008 |
PD-1 |
Cisplatino + gemcitabina |
I/II |
NCT04750382 |
INf-a2b + Rintatolimod + Celecoxib |
Modulación de citosinas |
Pembrolizumab |
I |
NCT03599453 |