|
Tabla 1: Características generales. |
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|
|
Total |
Original |
p |
TAILORx |
p |
||||
|
Bajo |
Intermedio |
Alto |
Bajo |
Intermedio |
Alto |
||||
|
n (%) |
n (%) |
n (%) |
n (%) |
n (%) |
n (%) |
||||
|
Pacientes |
136 |
72 (52.9) |
49 (36.03) |
15 (11.03) |
|
28 (20.59) |
86 (63.24) |
22 (16.18) |
|
|
Edad (media) |
55.04 |
55.52 |
55.26 |
51.93 |
0.854 |
60.68 |
53.67 |
53.18 |
0.013 |
|
Histología |
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|
Ductal invasor |
117 (86.0) |
64 (88.9) |
38 (77.6) |
15 (100) |
|
24 (85.7) |
73 (84.9) |
20 (90.9) |
|
|
Lobulillar invasor |
11 (8.1) |
4 (5.6) |
7 (14.3) |
0 (0) |
0.115 |
1 (3.6) |
8 (9.3) |
2 (9.1) |
0.729 |
|
Mucinoso |
5 (3.7) |
2 (2.8) |
3 (6.1) |
0 (0) |
|
1 (3.6) |
4 (4.7) |
0 (0.0) |
|
|
Mixto |
3 (2.2) |
2(2.8) |
1 (2.0) |
0 (0) |
|
2 (7.1) |
1 (1.2) |
0 (0.0) |
|
|
Cirugía |
|
|
|
|
|
|
|
|
|
|
MRM |
60 (45.5) |
35 (51.5) |
19 (38.8) |
6 (40.0) |
|
12 (46.2) |
38 (45.2) |
10 (45.5) |
|
|
MS |
7 (5.3) |
2 (2.9) |
5 (10.2) |
0 (0.0) |
0.778 |
1 (3.8) |
6 (7.1) |
0 (0.0) |
0.883 |
|
MCCAP |
13 (9.8) |
6 (8.8) |
3 (6.1) |
4 (26.7) |
|
2 (7.7) |
7 (8.3) |
4 (18.2) |
|
|
CC |
52 (39.4) |
25 (36.8) |
22 (44.9) |
5 (33.3) |
|
11 (42.3) |
33 (39.3) |
8 (36.4) |
|
|
Tamaño tumoral |
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|
T1mi |
1 (0.7) |
1 (1.4) |
0 (0.0) |
0 (0.0) |
|
1 (3.6) |
0 (0.0) |
0 (0.0) |
|
|
T1a |
4 (2.9) |
3 (4.2) |
1 (2.0) |
0 (0.0) |
0.858 |
0 (0.0) |
4 (4.7) |
0 (0.0) |
0.815 |
|
T1b |
31 (22.8) |
16 (22.2) |
10 (20.4) |
5 (33.3) |
|
6 (21.4) |
19 (22.1) |
6 (27.3) |
|
|
T1c |
74 (54.4) |
39 (54.2) |
29 (59.2) |
6 (40.0) |
|
16 (57.1) |
48 (55.8) |
10 (45.5) |
|
|
T2 |
26 (19.1) |
13 (18.1) |
9 (18.4) |
4 (26.7) |
|
5 (17.9) |
15 (17.4) |
6 (27.3) |
|
|
Ganglios |
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|
pN0 |
111 (81.6) |
64 (88.9) |
35 (71.4) |
12 (80.0) |
0.052 |
25 (89.3) |
70 (81.4) |
16 (72.7) |
0.443 |
|
pN1 |
25 (18.4) |
8 (11.1) |
14 (28.6) |
3 (20.0) |
|
3 (10.7) |
16 (18.6) |
6 (27.3) |
|
|
Etapa clínica |
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|
IA |
93 (68.4) |
56 (77.8) |
28 (57.1) |
9 (60.0) |
0.139 |
21 (75.0) |
60 (69.8) |
12 (54.5) |
0.202 |
|
IB |
5 (3.7) |
1 (1.4) |
4 (8.2) |
0 (0.0) |
|
0 (0.0) |
5 (5.8) |
0 (0.0) |
|
|
IIA |
36 (26.5) |
14 (19.4) |
16 (32.7) |
6 (40.0) |
|
7 (25.0) |
19 (22.1) |
10 (45.5) |
|
|
IIB |
2 (1.5) |
1 (1.4) |
1 (2.0) |
0 (0.0) |
|
0 (0.0) |
2 (2.3) |
0 (0.0) |
|
|
RE |
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|
Positivo |
136 (100.0) |
72 (100.0) |
49 (100.0) |
15 (100.0) |
– |
28 (100.0) |
86 (100.0) |
22 (100.0) |
– |
|
Negativo |
0 (0.0) |
0 (0.0) |
0 (0.0) |
0 (0.0) |
|
0 (0.0) |
0 (0.0) |
0 (0.0) |
|
|
RP |
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|
Positivo |
120 (88.2) |
70 (97.2) |
42 (85.7) |
8 (53.3) |
– |
27 (96.4) |
81 (94.2) |
12 (54.5) |
– |
|
Negativo |
16 (11.8) |
2 (2.8) |
7 (14.3) |
7 (46.7) |
|
1 (3.6) |
5 (5.8) |
10 (45.5) |
|
|
RE % media |
76.02 |
75.94 |
75.79 |
76.02 |
0.483 |
76.85 |
75.94 |
76.02 |
0.650 |
|
RP % media |
57.8 |
59.3 |
58.56 |
59.71 |
0.339 |
59.0 |
59.34 |
59.71 |
0.371 |
|
RE > 50% |
105 (82.0) |
60 (87.0) |
36 (81.8) |
9 (60.0) |
0.022 |
27 (100.0) |
65 (80.2) |
13 (65.0) |
0.004 |
|
RP > 50% |
83 (63.4) |
52 (75.4) |
26 (55.3) |
5 (33.3) |
< 0.001 |
24 (88.9) |
51 (61.4) |
8 (38.1) |
< 0.001 |
|
Her2 (-) |
135 (99.3) |
72 (100.0) |
49 (100.0) |
14 (93.3) |
|
28 (100.0) |
86 (100.0) |
21 (95.5) |
|
|
Grado Dif. |
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|
G1 |
39 (28.7) |
27 (37.5) |
11 (22.4) |
1 (6.7) |
0.010 |
9 (32.1) |
29 (33.7) |
1 (4.5) |
0.008 |
|
G2 |
83 (61.0) |
41 (56.9) |
31 (63.3) |
11 (73.3) |
|
17 (60.7) |
50 (58.1) |
16 (72.7) |
|
|
G3 |
14 (10.3) |
4 (5.6) |
7 (14.3) |
3 (20.0) |
|
2 (7.1) |
7 (8.1) |
5 (22.7) |
|
|
Ki67 media |
15.90 |
12.86 |
15.04 |
33.35 |
0.079 |
13.34 |
12.56 |
32.24 |
0.088 |
|
Ki67 > 14% |
55 (40.4) |
27 (37.5) |
16 (32.7) |
12 (80.0) |
0.004 |
10 (35.7) |
28 (32.6) |
17 (77.3) |
0.001 |
|
ILV+ |
41(30.1) |
18 (25.0) |
14 (28.6) |
9 (60.0) |
0.026 |
5 (17.9) |
25 (29.1) |
11 (50.0) |
0.046 |
|
IPN+ |
29 (21.3) |
15 (20.8) |
9 (18.4) |
5 (33.3) |
0.460 |
22 (78.6) |
69 (80.2) |
16 (72.7) |
0.745 |
|
MRM = mastecomía radica modificada, MS = mastectomía simple, MCCAP = mastectomía conservadora de complejo areola pezón, CC = cirugía conservadora, ILV = invasión linfovascular, IPN = invasión perineural. |
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