Tabla 2: Muerte celular por tumor primario y tipo de quimioterapia en líquido de ascitis. |
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Identifi- cación |
Primario |
Línea |
Cisplatino |
Carboplatino |
Oxilaplatino |
Paclitaxel |
Docetaxel |
Irinotecan |
Topotecan |
Etopósido |
Doxorrubicina |
Gemcitabina |
5FU |
AAALC3 |
Colangiocarcinoma |
4 |
71.6 (2.9) |
7.1 (1.4) R |
28.5 (3.0) R |
53.8 (0.4) |
94.7 (0.1) |
20.3 (3.4) R |
NP |
NP |
NP |
59.6 (2.8) |
24.1 (3.6) R |
LUCALC4 |
Colangiocarcinoma |
0 |
45.6 (1.6) R |
6.7 (4.4) R |
35.8 (4.5) R |
47.3 (1.2) R |
87.0 (0.5) |
31.5 (3.2) R |
37.2 (2.2) R |
NP |
29.3 (1.8) R |
37.2 (2.2) R |
29.3 (1.8) R |
LUCALC12 |
Colorrectal |
3 |
40.8 (3.5) R |
5.9 (2.1) R |
19.4 (0.9) R |
36.6 (2.2) R |
83.6 (0.4) |
19.9 (3.6) R |
12.7 (9.3) R |
NP |
NP |
59.3 (2.0) |
21.3 (2.0) R |
YDLC10 |
Colorrectal |
2 |
NP |
20.5 (4.6) R |
42.1 (0.8) R |
25.9 (3.2) R |
97.7 (0.7) |
NP |
27.7 (3.2) R |
NP |
64 |
NP |
31.8 (0.8) R |
AAALC7 |
Colorrectal |
0 |
65.0 (1.4) |
4.2 (4.4) R |
26.6 (3.3) R |
50.1 (4.7) R |
90.3 (1.7) |
26.2 (4.9) R |
NP |
NP |
NP |
56.8 (3.8) |
27.6 (3.5) R |
AAALC10 |
Colorrectal |
1 |
76.1 (1.7) |
5 (4.3) R |
18 (2.8) R |
38.2 (4.8) R |
90.8 (0.3) |
29.8 (3.6) R |
NP |
NP |
NP |
56.6 (0.1) |
25.3 (1.6) R |
YUSLC3 |
Colorrectal |
2 |
18.7 (4.5) R |
8.3 (2.5) R |
19.4 (3.7) R |
NP |
90.3 (1.1) |
21.8 (3.8) R |
16 (2.9) R |
NP |
NP |
41.4 (1.5) R |
72.6 (1.3) |
ONCOLC1 |
C Hepatocelular |
2 |
77.8 (0.7) |
16.6 (5.5) R |
40.6 (5.6) R |
65.8 (4.1) R |
94.6 (0.5) |
44.9 (4.9) R |
NP |
NP |
NP |
65.3 (4.6) |
26.8 (4.3) R |
AAALC5 |
C Hepatocelular |
1 |
70.1 (0.8) |
10.0 (2.2) R |
30.2 (3.1) R |
62.1 (0.4) |
94.9 (0.02) |
42.1 (2.6) R |
NP |
NP |
NP |
49.5 (2.7) R |
53.0 (0.2) |
AAALC2 |
Mama |
2 |
78.6 (1.1) |
17.0 (3.6) R |
23.6 (3.8) R |
43.5 (2.4) R |
96.0 (0.5) |
38.7 (3.8) R |
NP |
NP |
96.6 (0.4) |
67.7 (3.6) |
44.7 (2.3) R |
YDA705 |
Mama |
2 |
10 (1.0) R |
NP |
NP |
14.0 (1.2) R |
NP |
NP |
NP |
NP |
72.0 (2.0) |
NP |
8.0 (1.1) R |
LUCALC13 |
Mama |
3 |
69.5 (2.3) |
19.2 (3.4) R |
25.1 (4.2) R |
36.2 (6.8) R |
87.8 (0.2) |
15.7 (3.8) R |
15.9 (3.4) |
NP |
NP |
NP |
20 (4.3) R |
AAALC13 |
Mama |
2 |
42.9 (4.9) R |
2.1 (4.2) R |
30.4 (6.1) R |
40.5 (3.2) R |
94.0 (0.2) |
35.3 (0.3) R |
NP |
NP |
NP |
57.0 (1.5) |
37.1 (1.4) R |
AAALC4 |
Páncreas |
1 |
NP |
NP |
33.7 (2.2) R |
NP |
NP |
34.7 (0.9) R |
NP |
NP |
NP |
44.9 (2.8) R |
33.9 (3.0) R |
YDLCAP8 |
Páncreas |
2 |
NP |
NP |
10.0 (1.0) R |
8.0 (1.1) R |
NP |
NP |
NP |
NP |
NP |
62.0 (2.0) |
4.0 (1.1) R |
LUCALC14 |
Páncreas |
3 |
41 (3.2) R |
9.8 (0.4) R |
19.2 (1.9) R |
40.5 (0.5) R |
79.6 (1.1) |
24.6 (3.2) R |
37.9 (6.2) |
NP |
NP |
NP |
29.5 (7.8) R |
ABCLC1 |
Páncreas |
2 |
76.2 (2.7) |
11.9 (3.7) R |
39.3 (2.9) R |
66.2 (5.6) R |
93.2 (0.1) |
38.9 (1.9) R |
NP |
NP |
NP |
76.08 (2.1) |
58.0 (3.5) |
AAALC8 |
Páncreas |
1 |
36.3 (3.6) R |
2.3 (0.3) R |
27.0 (4.5) R |
32.9 (3.9) R |
89.8 (0.3) |
46.3 (2.5) R |
NP |
NP |
NP |
50.8 (1.7) R |
44.6 (1.4) R |
ABCLC6 |
Páncreas |
2 |
47.7 (0.7) R |
18.5 (0.1) R |
28.5 (1.2) R |
57.0 (0.2) |
90.1 (0.3) |
45.1 (9.5) R |
NP |
NP |
NP |
55.3 (0.5) |
43.2 (4.8) R |
YDLCP4 |
Páncreas |
5 |
30.8 (0.5) R |
NP |
NP |
14.0 (0.7) R |
27.0 (1.6) R |
NP |
NP |
NP |
26.0 (2.0) R |
NP |
9.0 (0.2) R |
R = resistencia = muerte celular < 50% con la dosis farmacológica 1.0X, NP = fármaco no probado, 5FU = 5 fluorouracilo. |