2020, Number 3
<< Back Next >>
Cuba y Salud 2020; 15 (3)
Ozone therapy and its application in relation to the pathophysiology of COVID 19 disease
Arenas FB, Calunga FJL, Menéndez CS, Vera YC
Language: Spanish
References: 10
Page: 104-107
PDF size: 348.93 Kb.
ABSTRACT
Ozone therapy is considered a complementary therapy that uses
ozone as a therapeutic agent. It is a procedure that has proven
to be effective in different pathologies in which very encouraging
results have been obtained. It has special importance in infectious
diseases and immunological conditions. Faced with the worldwide
situation due to the COVID-19 pandemic, which today takes on
an alarming magnitude as a health problem in the world, it was
decided to make this communication, based on the knowledge that
ozone therapy, according to the pathophysiology of the damage caused by this process can be useful as a complementary therapy.
This work aims to identify the mechanisms of action of ozone and
the justification for its use in infection by the new coronavirus SARSCoV-
2 based on scientific evidence, which is why it is concluded
with the development of a treatment protocol well differentiated
according to the classification of the clinical stage and severity
of the patient, as well as its correspondence with the routes of
administration.
REFERENCES
Bocci V, Zanardi D M, Travagli V. Mechanisms of action and chemical-biological interactions between ozone and body compartments: a critical appraisal of the different administration routes. Current Drug Therapy 2009, 4: 159-73.
Calunga JL, Paz Y, Menéndez S, Martínez A, Hernández A. La ozonoterapia en pacientes con enfisema pulmonar. Rev Med Chile, 2011; 139: 439-447.
Menéndez S. Mecanismos de acción biológica y efectos terapéuticos del ozono. En: Menéndez S, González R, Ladea OE, Hernández F, León OS, Díaz M. Ozono: Aspectos Básicos y Aplicaciones Clínicas. 1ra Ed. La Habana: CENIC; 2008. p. 4-107.
Bocci V. Scientific and medical aspects of ozone therapy. State of the art. Arch Med Res 2006; 37: 425-35.
Bocci V, Borelli E, Travagli V, Zanardi I. The ozone paradox: ozone is a strong oxidant as well as a medical drug. Med Res Rev. 2009; 29: 646-82.
Travagli V, Zanardi I, Silvietti A, Bocci V. A physicochemical investigation on the effects of ozone on blood. Int J Biol Macromol. 2007; 41: 504-11.
Larini A, Bocci V. Effects of ozone on isolated peripheral blood mononuclear cells. Toxicology in Vitro 2005 Feb; 19(1): 55-61.
Abbas AK. Activation of lymphocytes. In: Abba AK, Lichtman A. Cellular and Molecular Immunology. 7ma ed. NY: WB Saunders Co. 2011. p. 203-24.
Bocci V, Brito GS. Ozone Therapy in Critical Patients. Rationale of the Therapy and Proposed Guidelines. Rivista Italiana di Ossigeno-Ozonoterapia 5: 7-11, 2006.
Rhee SG, Bae YS, Lee SR, Kwon J. Hydrogen peroxide a key messenger that module protein phosphorylation through cysteine oxidation. Sci STKE 2000; Oct 10: 53.