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ISSN 1025-0255 (Electronic)

2020, Number 6

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AMC 2020; 24 (6)

Fludarabine in the treatment of follicular non-Hodgkin lymphoma

Moreno-Laguarda Y, Laguna-Salvia L, Larquin-Comet JI, León-Ramentol CC

Language: Spanish
References: 28
Page: 856-867
PDF size: 566.23 Kb.


ABSTRACT

Background: follicular non-Hodgkin's lymphoma occupies the second place among non-Hodgkin's lymphomas of line B, they are characterized by a pattern of continuous remissions and relapses. Fludarabine constitutes a treatment option for the same as it achieves a rapid remission, with a decrease in the percentage of relapse.
Objective: to evaluate fludarabine as a rescue treatment for follicular non-Hodgkin lymphoma.
Methods: a concurrent prospective longitudinal, analytical, observational cohort study was conducted. The study universe was made up of patients who attended the Hematology consultation with a diagnosis of follicular non-Hodgkin's lymphoma and consisted of 63 patients, of which 21 were selected by intentional non-probabilistic sampling who received treatment with fludarabine, made up a cohort of exposed, these were compared with 42 patients with similar characteristics who received other poly-chemotherapy regimens that did not include fludarabine and they constituted the unexposed cohort.
Results: the number of male patients over 50 years of age, belonging to Cotswold stage IV, and those with a low-intermediate risk of relapse was greater. The disease-free survival time was longer in those treated with fludarabine, who had fewer complications.
Conclusions: in patients treated with fludarabine as rescue treatment for follicular lymphoma, the disease-free survival time was longer and there were fewer complications, which show its usefulness as a first-line treatment in the absence of rituximab.


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