2021, Number 2
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Rev Biomed 2021; 32 (2)
Importance of the metabolism and consumption of vitamins d and c during SArS-coV-2 infection
Troncoso-Gómez CA, Luna-Mendoza RI, Molina-Martínez LM, Sifuentes-Franco S
Language: Spanish
References: 82
Page: 124-135
PDF size: 538.49 Kb.
ABSTRACT
Introduction. Since December 2019, the world has experienced a
public health emergency due to the appearance of a new coronavirus,
SARS-CoV-2. Epidemiological studies suggest that the capacity of the
immune system modifi ed by various risk factors may be a determining
factor in the prognosis of the patient, as well as an important protective
eff ect has been attributed to vitamins D and C.
Objective. This review aims to investigate the possible
protective mechanisms of vitamins C and D as antioxidants and
immunomodulators during COVID-19 disease.
Methodology. A systematic search in databases such as PUBMED
was used to identify clinical studies, as well as studies in animal and
in vitro models that propose the mechanisms by which vitamins C
and D may play an anti-inflammatory and antioxidant role during
infection with COVID-19.
REFERENCES
Cheng ZJ, Shan J. 2019 Novel coronavirus: where we are and what we know. Infection. 2020 Apr;48(2):155- 63. doi: 10.1007/s15010-020-01401-y.
World Health Organization, WHO Press conference [Internet]. Ginebra, Suiza: World Health Organization. 2020 April [cited 2020nov]. Available from: https:// www.who.int/es
Jureka AS, Silvas JA, Basler CF. Propagation, Inactivation, and Safety Testingof SARS-CoV-2. Viruses. 2020 Jun 6;12(6):622. doi: 10.3390/v12060622.
Tyrrell DAJ, Myint SH. Coronaviruses. In: Baron S, editor. Medical Microbiology. 4th edition. Galveston (TX): University of Texas Medical Branch at Galveston; 1996. Chapter 60.
Esakandari H, Nabi-Afjadi M, Fakkari-Afjadi J, Farahmandian N, Miresmaeili SM, Bahreini E. A comprehensive review of COVID-19 characteristics. Biol Proced Online. 2020 Aug 4; 22:19. doi: 10.1186/ s12575-020-00128-2.
Zhong NS, Zheng BJ, Li YM, Poon, Xie ZH, Chan KH, et al. Epidemiology and cause of severe acute respiratory syndrome (SARS) in Guangdong, People’s Republic of China, in February 2003. Lancet. 2003 Oct 25;362(9393):1353-58. doi: 10.1016/s0140- 6736(03)14630-2.
Ortiz-Prado E, Simbaña-Rivera K, Gómez-Barreno L, Rubio-Neira M, Guaman LP, Kyriakidis NC, et al. Clinical, molecular, and epidemiological characterization of the SARS-CoV-2 virus and the Coronavirus Disease 2019 (COVID-19), a comprehensive literature review. Diagn Microbiol Infect Dis. 2020 Sep;98(1):115094. doi: 10.1016/j.diagmicrobio.2020.115094.
Fernández-Rodríguez A, Casas I, Culebras E, Morilla E, Cohen M, Alberola J. COVID-19 y estudios microbiológicos post-mortem. Spanish Journal of Legal Medicine. May;46(3)127-38. doi: 10.1016/j. reml.2020.05.007.
Informe SARS-CoV-2. Clasificación, estructura, composición de la partícula viral, organización del genoma y proteínas codificadas [Internet]. Sociedad Argentina de Virología, División de la Asociación Argentina de Microbiología. 2020.2020March26 [cited 2020nov] ;(1):6-9. Available from: https://www.aam. org.ar/src/img_up/02042020.1.pdf
Yan R, Zhang Y, Li Y, Xia L, Guo Y, Zhou Q. Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2. Science. 2020 Mar 27;367(6485):1444-8. doi: 10.1126/science.abb2762.
Guo YR, Cao QD, Hong ZS, Tan YY, Chen SD, Jin HJ, et al. The origin, transmission, and clinical therapies on coronavirus disease 2019 (COVID-19) outbreak - an update on the status. Mil Med Res. 2020 Mar 13;7(1):11. doi: 10.1186/s40779-020-00240-0.
Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020 Feb 15;395(10223):497- 506. doi: 10.1016/S0140-6736(20)30183-5.
Lu H, Stratton CW, Tang YW. Outbreak of pneumonia of unknown etiology in Wuhan, China: The mystery and the miracle. J Med Virol. 2020 Apr;92(4):401-2. doi: 10.1002/jmv.25678.
Casola A, Burger N, Liu T, Jamaluddin M, Brasier AR, Garofalo RP. Oxidant tone regulates RANTES gene expression in air way epithelial cells infected with respiratory syncytial virus. Role in viral-induced interferon regulatory factor activation. J Biol Chem. 2001 Jun 8;276(23):19715-22. doi: 10.1074/jbc.M101526200.
Gjyshi O, Bottero V, Veettil MV, Dutta S, Singh VV, Chikoti L, Chandran B. Kaposi’s sarcoma-associated herpes virus induces Nrf2 during de novo infection of endothelial cells to create a microenvironment conducive to infection. PLoS Pathog. 2014 Oct 23;10(10): e1004460. doi: 10.1371/journal.ppat.1004460.
Blanco-Melo D, Nilsson-Payant BE, Liu WC, Uhl S, Hoagland D, Møller R, et al. Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19. Cell. 2020 May 28;181(5):1036-45.e9. doi: 10.1016/j. cell.2020.04.026.
Terán-Cabanillas E, Hernández J. Role of Leptin and SOCS3 in Inhibiting the Type I Interferon Response During Obesity. Inflammation. 2017 Feb;40(1):58-67. doi: 10.1007/s10753-016-0452-x.
Sa Ribero M, Jouvenet N, Dreux M, Nisole S. Interplay between SARS-CoV-2 and the type I interferon response. PLoS Pathog. 2020 Jul 29;16(7): e1008737. doi: 10.1371/journal.ppat.1008737.
Zhang L, Liu Y. Potential interventions for novel coronavirus in China: A systematic review. J Med Virol. 2020 May;92(5):479-90. doi: 10.1002/jmv.25707.
Grant WB, Giovannucci E. The possible roles of solar ultraviolet-B radiation and vitamin D in reducing casefatality rates from the 1918-1919 influenza pandemic in the United States. Dermato Endocrinol. 2009 Jul;1(4):215-9. doi: 10.4161/derm.1.4.9063.
Valero N, Mosquera J, Alcocer S, Bonilla E, Salazar J, Álvarez-Mon M. Melatonin, minocycline, and ascorbic acid reduce oxidative stress and viral titers and increase survival rate in experimental Venezuelan equine encephalitis. Brain Res. 2015 Oct 5; 1622:368-76. doi: 10.1016/j.brainres.2015.06.034.
Cai Y, Li YF, Tang LP, Tsoi B, Chen M, Chen H, et al. A new mechanism of vitamin C effects on A/ FM/1/47(H1N1) virus-induced pneumonia in restraintstressed mice. Biomed Res Int. 2015; 2015:675149. doi: 10.1155/2015/675149.
Maestro MA, Molnár F, Carlberg C. Vitamin D and Its Synthetic Analogs. J Med Chem. 2019 Aug 8;62(15):6854- 6875. doi: 10.1021/acs.jmedchem.9b00208.
Wolpowitz D, Gilchrest BA. The vitamin D questions: how much do you need and how should you get it? J Am Acad Dermatol. 2006 Feb;54(2):301-17. doi: 10.1016/j. jaad.2005.11.1057.
DeLuca HF. Vitamin D: Historical Overview. Vitam Horm. 2016; 100:1-20. doi: 10.1016/bs.vh.2015.11.001.
Grant WB, Lahore H, McDonnell SL, Baggerly CA, French CB, Aliano JL, Bhattoa HP. Evidence that Vitamin D Supplementation Could Reduce Risk of Influenza and COVID-19 Infections and Deaths. Nutrients. 2020 Apr 2;12(4):988. doi: 10.3390/nu12040988.
Jayawardena R, Sooriyaarachchi P, Chourdakis M, Jeewandara C, Ranasinghe P. Enhancing immunity in viral infections, with special emphasis on COVID-19: A review. Diabetes Metab Syndr. 2020 Jul- Aug;14(4):367-82. doi: 10.1016/j.dsx.2020.04.015.
Arrigoni O, De Tullio MC. Ascorbic acid: much more than just an antioxidant. Biochim Biophys Acta. 2002 Jan 15;1569(1-3):1-9. doi: 10.1016/s0304-4165(01)00235- 5.
Lee C. Therapeutic Modulation of Virus-Induced Oxidative Stress via the Nrf2-Dependent Antioxidative Pathway. Oxid Med Cell Longev. 2018 Oct 31; 2018:6208067. doi: 10.1155/2018/6208067.
Carr AC, Maggini S. Vitamin C and Immune Function. Nutrients. 2017 Nov 3;9(11):1211. doi: 10.3390/ nu9111211.
Akaike T. Role of free radicals in viral pathogenesis and mutation. Rev Med Virol. 2001 Mar-Apr;11(2):87-101. doi: 10.1002/rmv.303.
Hiedra R, Lo KB, Elbashabsheh M, Gul F, Wright RM, Albano J, et al. The use of IV vitamin C for patients with COVID-19: a case series. Expert Rev Anti Infect Ther. 2020 Aug 1:1-3. doi: 10.1080/14787210.2020.1794819.
Prauchner CA. Oxidative stress in sepsis: Pathophysiological implications justifying antioxidant co-therapy. Burns. 2017 May;43(3):471-85. doi: 10.1016/j.burns.2016.09.023.
Atherton JG, Kratzing CC, Fisher A. The effect of ascorbic acid on infection chick-embryo ciliated tracheal organ cultures by coronavirus. Arch Virol. 1978;56(3):195-9. doi: 10.1007/BF01317848.
Marik PE, Khangoora V, Rivera R, Hooper MH, Catravas J. Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study. Chest. 2017 Jun;151(6):1229-38. doi: 10.1016/j.chest.2016.11.036.
Rhodes JM, Subramanian S, Laird E, Griffin G, Kenny RA. Perspective: Vitamin D deficiency and COVID-19 severity - plausibly linked by latitude, ethnicity, impacts on cytokines, ACE2 and thrombosis. J Intern Med. 2020 Jul 2:10.1111/joim.13149. doi: 10.1111/joim.13149.
Honardoost M, Ghavideldarestani M, Khamseh ME. Role of vitamin D in pathogenesis and severity of COVID-19 infection. Arch Physiol Biochem. 2020 Oct 30:1-7. doi: 10.1080/13813455.2020.1792505.
Weir EK, Thenappan T, Bhargava M, Chen Y. Does vitamin D deficiency increase the severity of COVID-19? Clin Med (Lond). 2020 Jul;20(4): e107-e108. doi: 10.7861/clinmed.2020-0301.
Malek Mahdavi A. A brief review of interplay between vitamin D and angiotensin-converting enzyme 2: Implications for a potential treatment for COVID-19. Rev Med Virol. 2020 Sep;30(5): e2119. doi: 10.1002/ rmv.2119.
Mansur JL, Tajer C, Mariani J, Inserra F, Ferder L, Manucha W. Vitamin D high doses supplementation could represent a promising alternative to prevent or treat COVID-19 infection. Clin Investig Arterioscler. 2020 May 29: S0214-9168(20)30048-6. English, Spanish. doi: 10.1016/j.arteri.2020.05.003.
Orchard L, Baldry M, Nasim-Mohi M, Monck C, Saeed K, Grocott MPW, Ahilanandan D; University Hospital Southampton Critical Care Team and the REACT COVID Investigators. Vitamin D levels and intensive care unit outcomes of a cohort of critically ill COVID-19 patients. Clin Chem Lab Med. 2021 Jan 18. doi: 10.1515/ cclm-2020-1567.
Shah K, Saxena D, Mavalankar D. Vitamin D supplementation, COVID-19 & Disease Severity: A meta-analysis. QJM. 2021 Jan 24: hcab009. doi: 10.1093/ qjmed/hcab009.
Ali N. Role of vitamin D in preventing of COVID-19 infection, progression, and severity. J Infect Public Health. 2020 Oct;13(10):1373-80. doi: 10.1016/j. jiph.2020.06.021.
Ling SF, Broad E, Murphy R, Pappachan JM, Pardesi- Newton S, Kong MF, Jude EB. High-Dose Cholecalciferol Booster Therapy is Associated with a Reduced Risk of Mortality in Patients with COVID-19: A Cross-Sectional Multi-Centre Observational Study. Nutrients. 2020 Dec 11;12(12):3799. doi: 10.3390/nu121237.
De Smet D, De Smet K, Herroelen P, Gryspeerdt S, Martens GA. Serum 25(OH)D Level on Hospital Admission Associated With COVID-19 Stage and Mortality. Am J Clin Pathol. 2021 Feb 11;155(3):381-8. doi: 10.1093/ajcp/aqaa252.
Nie X, Chen J, Ye F, Wang H, Tang L, Wang L. Oral high dose vitamin D for the treatment of diabetic patients with COVID-19: A protocol for systematic review and meta-analysis. Medicine (Baltimore). 2021 Mar 5;100(9):e24517. doi: 10.1097/MD.0000000000024517.
Li S, Cao Z, Yang H, Zhang Y, Xu F, Wang Y. Metabolic Healthy Obesity, Vitamin D Status, and Risk of COVID-19. Aging Dis. 2021 Feb 1;12(1):61-71. doi: 10.14336/AD.2020.1108.
Cuschieri S, Grech S. Obesity population at risk of COVID-19 complications. Glob Health Epidemiol Genom. 2020 Nov 6;5: e6. doi: 10.1017/gheg.2020.6.
Fox SE, Akmatbekov A, Harbert JL, Li G, Quincy Brown J, Vander Heide RS. Pulmonary and cardiac pathology in African American patients with COVID-19: an autopsy series from New Orleans. Lancet Respir Med. 2020 Jul;8(7):681-6. doi: 10.1016/S2213-2600(20)30243-5.
Sengupta T, Majumder R, Majumder S. Role of vitamin D in treating COVID-19-associated coagulopathy: problems and perspectives. Mol Cell Biochem. 2021 Feb 18:1–7. doi: 10.1007/s11010-021-04093-6.
Martinez-Moreno JM, Herencia C, Montes de Oca A, Muñoz-Castañeda JR, Rodríguez-Ortiz ME, Díaz- Tocados JM, et al. Vitamin D modulates tissue factor and protease-activated receptor 2 expression in vascular smooth muscle cells. FASEB J. 2016 Mar;30(3):1367- 76. doi: 10.1096/fj.15-272872.
Topaloglu O, Arslan MS, Karakose M, Ucan B, Ginis Z, Cakir E, et al. Is there any association between thrombosis and tissue factor pathway inhibitor levels in patients with vitamin D deficiency? Clin Appl Thromb Hemost. 2015 Jul;21(5):428-33. doi: 10.1177/1076029613509477.
Khademvatani K, Seyyed-Mohammadzad MH, Akbari M, Rezaei Y, Eskandari R, Rostamzadeh A. The relationship between vitamin D status and idiopathic lower-extremity deep vein thrombosis. Int J Gen Med. 2014 Jun 19; 7:303-9. doi: 10.2147/IJGM.S64812.
Shiravi AA, Saadatkish M, Abdollahi Z, Miar P, Khanahmad H, Zeinalian M. Vitamin D can be effective on the prevention of COVID-19 complications: A narrative review on molecular aspects. Int J Vitam Nutr Res. 2020 Aug 19:1-13. doi: 10.1024/0300-9831/ a000676.
The potential link between inherited G6PD deficiency, oxidative stress, and vitamin D deficiency and the racial inequities in mortality associated with COVID-19. Free Radic Biol Med. 2020 Oct 7; 161:84-91. doi: 10.1016/j. freeradbiomed.2020.10.002.
Beard JA, Bearden A, Striker R. Vitamin D and the antiviral state. J Clin Virol. 2011 Mar;50(3):194-200. doi: 10.1016/j.jcv.2010.12.006.
Bouillon R, Schuit F, Antonio L, Rastinejad F. Vitamin D Binding Protein: A Historic Overview. Front Endocrinol (Lausanne). 2020 Jan 10; 10:910. doi: 10.3389/ fendo.2019.00910.
Speeckaert MM, Speeckeart R, Delanghe JR. Genetic polymorphisms, vitamin D binding protein and vitamin D deficiency in COVID-19. Eur Respir J. 2021 Feb 4:2004638. doi: 10.1183/13993003.04638-2020.
Karcioglu Batur L, Hekim N. The role of DBP gene polymorphisms in the prevalence of new coronavirus disease 2019 infection and mortality rate. J Med Virol. 2021 Mar;93(3):1409-13. doi: 10.1002/jmv.26409.
Alshahawey M. A genetic insight into vitamin D binding protein and COVID-19. Med Hypotheses. 2021 Feb 9; 149:110531. doi: 10.1016/j.mehy.2021.110531.
Grant WB, Lahore H, McDonnell SL, Baggerly CA, French CB, Aliano JL, Bhattoa HP. Evidence that Vitamin D Supplementation Could Reduce Risk of Influenza and COVID-19 Infections and Deaths. Nutrients. 2020 Apr 2;12(4):988. doi: 10.3390/nu12040988.
Mansur JL, Tajer C, Mariani J, Inserra F, Ferder L, Manucha W. Vitamin D high doses supplementation could represent a promising alternative to prevent or treat COVID-19 infection. Clin Investig Arterioscler. 2020 Nov-Dec;32(6):267-77. English, Spanish. doi: 10.1016/j.arteri.2020.05.003.
Griffin G, Hewison M, Hopkin J, Kenny RA, Quinton R, Rhodes J, et al. Perspective: Vitamin D supplementation prevents rickets and acute respiratory infections when given as daily maintenance but not as intermittent bolus: implications for COVID-19. Clin Med (Lond). 2021 Feb 16: clinmed.2021-0035. doi: 10.7861/ clinmed.2021-0035.
Lordan R. Notable Developments for Vitamin D Amid the COVID-19 Pandemic, but Caution Warranted Overall: A Narrative Review. Nutrients. 2021 Feb 26;13(3):740. doi: 10.3390/nu13030740.
Shirvani A, Kalajian TA, Song A, Holick MF. Disassociation of Vitamin D’s Calcemic Activity and Non-calcemic Genomic Activity and Individual Responsiveness: A Randomized Controlled Double- Blind Clinical Trial. Sci Rep. 2019 Nov 27;9(1):17685. doi: 10.1038/s41598-019-53864-1.
Alshahrani F, Aljohani N. Vitamin D: deficiency, sufficiency, and toxicity. Nutrients. 2013 Sep 13;5(9):3605-16. doi: 10.3390/nu5093605.
Galior K, Grebe S, Singh R. Development of Vitamin D Toxicity from Overcorrection of Vitamin D Deficiency: A Review of Case Reports. Nutrients. 2018 Jul 24;10(8):953. doi: 10.3390/nu10080953.
Kim H, Jang M, Kim Y, Choi J, Jeon J, Kim J, et al. Red ginseng and vitamin C increase immune cell activity and decrease lung inflammation induced by influenza A virus/H1N1 infection. J Pharm Pharmacol. 2016 Mar;68(3):406-20. doi: 10.1111/jphp.12529.
Mousavi S, Bereswill S, Heimesaat MM. Immunomodulatory and Antimicrobial Effects of Vitamin C. Eur J Microbiol Immunol (Bp). 2019 Aug 16;9(3):73-9. doi: 10.1556/1886.2019.00016.
Hemilä H, Chalker E. Vitamin C as a Possible Therapy for COVID-19. Infect Chemother. 2020 Jun;52(2):222- 3. doi: 10.3947/ic.2020.52.2.222.
Murdaca G, Pioggia G, Negrini S. Vitamin D and Covid-19: an update on evidence and potential therapeutic implications. Clin Mol Allergy. 2020 Nov 19;18(1):23. doi: 10.1186/s12948-020-00139-0.
Liu F, Zhu Y, Zhang J, Li Y, Peng Z. Intravenous highdose vitamin C for the treatment of severe COVID-19: study protocol for a multicenter randomized controlled trial. BMJ Open. 2020 Jul 8;10(7): e039519. doi: 10.1136/bmjopen-2020-039519.
Fiorino S, Gallo C, Zippi M, Sabbatani S, Manfredi R, Moretti R, et al. Cytokine storm in aged people with CoV-2: possible role of vitamins as therapy or preventive strategy. Aging Clin Exp Res. 2020 Oct;32(10):2115-31. doi: 10.1007/s40520-020-01669-y.
Jamali Moghadam Siahkali S, Zarezade B, Koolaji S, SeyedAlinaghi S, Zendehdel A, Tabarestani M, et al. Safety and effectiveness of high-dose vitamin C in patients with COVID-19: a randomized open-label clinical trial. Eur J Med Res. 2021 Feb 11;26(1):20. doi: 10.1186/s40001-021-00490-1.
Liu F, Zhu Y, Zhang J, Li Y, Peng Z. Intravenous highdose vitamin C for the treatment of severe COVID-19: study protocol for a multicentre randomized controlled trial. BMJ Open. 2020 Jul 8;10(7): e039519. doi: 10.1136/bmjopen-2020-039519.
Santos HO, Tinsley GM, da Silva GAR, Bueno AA. Pharmaconutrition in the Clinical Management of COVID-19: A Lack of Evidence-Based Research But Clues to Personalized Prescription. J Pers Med. 2020 Sep 25;10(4):145. doi: 10.3390/jpm10040145.
Feyaerts AF, Luyten W. Vitamin C as prophylaxis and adjunctive medical treatment for COVID-19? Nutrition. 2020 Nov-Dec;79-80:110948. doi: 10.1016/j. nut.2020.110948.
Farjana M, Moni A, Sohag AAM, Hasan A, Hannan MA, Hossain MG, Uddin MJ. Repositioning Vitamin C as a Promising Option to Alleviate Complications associated with COVID-19. Infect Chemother. 2020 Dec;52(4):461- 77. doi: 10.3947/ic.2020.52.4.461.
Hernández A, Papadakos PJ, Torres A, González DA, Vives M, Ferrando C, Baeza J. Two known therapies could be useful as adjuvant therapy in critical patients infected by COVID-19. Rev Esp Anestesiol Reanim. 2020 May;67(5):245-52. English, Spanish. doi: 10.1016/j.redar.2020.03.004.
Doseděl M, Jirkovský E, Macáková K, Krčmová LK, Javorská L, Pourová J, et al. On Behalf of The Oemonom. Vitamin C-Sources, Physiological Role, Kinetics, Deficiency, Use, Toxicity, and Determination. Nutrients. 2021 Feb 13;13(2):615. doi: 10.3390/nu13020615.
Bae M, Kim H. Mini-Review on the Roles of Vitamin C, Vitamin D, and Selenium in the Immune System against COVID-19. Molecules. 2020 Nov 16;25(22):5346. doi: 10.3390/molecules25225346.
Shakoor H, Feehan J, Al Dhaheri AS, Ali HI, Platat C, Ismail LC, et al. Immune-boosting role of vitamins D, C, E, zinc, selenium, and omega-3 fatty acids: Could they help against COVID-19? Maturitas. 2021 Jan; 143:1-9. doi: 10.1016/j.maturitas.2020.08.003.